公开(公告)号：US3900464A

公开(公告)日：1975-08-19

申请号：US31872872

申请日：1972-12-27

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  LANZ PAUL ,  QUITT PETER ,  VOGLER KARL ,  VOGLER HEIR BY FRANZISKA ,  VOGLER HEIR BY NIKLAUS E ,  VOGLER HEIR BY HEINRICH

IPC: C07D207/32 ,  C07D207/327 ,  C07D209/18 ,  C07D213/55 ,  C07D257/04 ,  C07D307/54 ,  C07D333/24 ,  C07D499/00 ,  C07D499/60 ,  C07D499/46

CPC classification number: C07D207/327 ,  C07D209/18 ,  C07D213/55 ,  C07D257/04 ,  C07D307/54 ,  C07D333/24 ,  C07D499/00 ,  Y02P20/55

Abstract: Novel antibiotic compounds represented by the formula

wherein R is a furyl, pyrrolyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, pyridyl, pyrimidinyl, tetrazolyl or indolyl radical which can be substituted with halogen, C1-C3-alkyl, C1-C3alkoxy or C1-C3-alkylthio and T is a C2-C5-alkyl group, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND HYDRATES OF SUCH SALTS, A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREOF ARE DISCLOSED.

公开(公告)号：US3886142A

公开(公告)日：1975-05-27

申请号：US31873672

申请日：1972-12-27

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  LANZ PAUL ,  VOGLER KARL ,  ZANETTI GUIDO

IPC: B25C5/02 ,  B25C5/06 ,  C07C51/60 ,  C07D499/00 ,  C07D499/60 ,  F16B15/04 ,  C07D99/16

CPC classification number: F16B15/04 ,  B25C5/0257 ,  B25C5/06 ,  C07C51/60 ,  C07D499/00 ,  Y10S411/92 ,  Y10S514/962 ,  Y10T29/49833 ,  C07C59/70

Abstract: WHEREIN R is halogen, lower alkyl, lower alkoxy, nitro, lower alkoxy-lower alkyl, dilower alkylamino, lower alkyl sulfonylamido, bis-lower alkylsulfonyl amido or lower alkanoyl amido, n is an integer of 0-2 and T is a C2-C5 alkyl group, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND HYDRATES OF SUCH SALTS, A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREFOR ARE DISCLOSED.
Novel antibiotic compounds represented by the formula

D R A W I N G

Abstract translation: 由式WHEREIN R表示的新型抗生素化合物是卤素，低级烷基，低级烷氧基，硝基，低级烷氧基 - 低级烷基，二元烷基氨基，低级烷基磺酰氨基，双 - 低级烷基磺酰基酰氨基或低级烷酰氨基，n是0〜 2和T是C 2 -C 5烷基，其药学上可接受的盐及其水合物，其制备和新型中间体的方法被公开。

公开(公告)号：US3917584A

公开(公告)日：1975-11-04

申请号：US31873872

申请日：1972-12-27

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  LANZ PAUL ,  VOGLER KARL ,  ZANETTI GUIDO

IPC: C07C51/60 ,  C07D499/00 ,  C07D499/60 ,  C07D499/44

CPC classification number: C07D499/00 ,  C07C51/60 ,  Y02P20/55 ,  C07C59/64

Abstract: Novel antibiotic compounds represented by the formula

wherein R is halogen, lower alkyl, lower alkoxy, lower alkylamino, di-lower alkylamino or lower alkanoylamino, n is an integer of 0-2 and T is a C2-C5 alkyl group, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND HYDRATES OF SUCH SALTS A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREOF ARE DISCLOSED.

Abstract translation: 由式-CH2-COO-CH-CO-NH- ||（R）nT S ANGLE CH3 CH-CHC ANGLE |||CH3 C --- N --- CH PARALLEL | OCOOH表示的新型抗生素化合物其中R 是卤素，低级烷基，低级烷氧基，低级烷基氨基，二低级烷基氨基或低级烷酰基氨基，n是0-2的整数，T是C2-C5烷基，其药学上可接受的盐及其等价物的方法 他们的准备和新闻中介被披露。

公开(公告)号：RO70672A

公开(公告)日：1982-08-17

申请号：RO6939572

申请日：1972-01-14

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  QUITT PETER ,  VOGLER KARL ,  LANZ PAUL

IPC: C07D499/12 ,  A61K31/431 ,  A61P31/04 ,  C07D207/28 ,  C07D207/34 ,  C07D213/78 ,  C07D213/79 ,  C07D213/89 ,  C07D215/48 ,  C07D215/50 ,  C07D217/26 ,  C07D231/14 ,  C07D233/90 ,  C07D239/54 ,  C07D239/557 ,  C07D261/18 ,  C07D263/34 ,  C07D277/56 ,  C07D285/06 ,  C07D307/68 ,  C07D309/12 ,  C07D333/38 ,  C07D499/00 ,  C07D499/56 ,  C07D499/60 ,  C07D499/52

Abstract: Compounds represented by the following formula WHEREIN A is a substituted or unsubstituted heterocyclic radical and T is a C2-C5 alkyl, alkenyl, cycloproplymethyl, cyclobutylmethyl or cyclopentyl group A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREFOR ARE DISCLOSED. These compounds are useful antibiotics.

公开(公告)号：HU170008B

公开(公告)日：1977-03-28

申请号：HUHO001538

申请日：1973-01-03

Applicant: HOFFMANN LA ROCHE

Inventor： LANZ PAUL ,  REINER ROLAND ,  VOGLER KARL

IPC: C07D499/00 ,  C07D499/60 ,  C07D501/20 ,  C07D501/28 ,  C07D499/48 ,  C07D207/08 ,  C07D499/58

公开(公告)号：CA1177823A

公开(公告)日：1984-11-13

申请号：CA373267

申请日：1981-03-18

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  LANZ PAUL

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D253/075 ,  C07D501/36

Abstract: RAN 4410/144 A cephalosporin derivative of the formula as well as readily hydrolysable esters and salts of this compound and hydrates of the compound of formula I or of esters and salts thereof. Further, also corresponding preparations, the use of these products in the treatment of illnesses, the manufacture of the active substances as well as intermediates thereby occurring.

公开(公告)号：AU4949272A

公开(公告)日：1974-05-30

申请号：AU4949272

申请日：1972-11-30

Applicant: HOFFMANN LA ROCHE

Inventor： LANZ PAUL ,  REINER ROLAND ,  VOGLER KARL

IPC: C07D499/00 ,  C07D499/60 ,  C07D501/20 ,  C07D501/28 ,  C07D99/16 ,  C07D99/24

公开(公告)号：DE2301543A1

公开(公告)日：1973-07-19

申请号：DE2301543

申请日：1973-01-12

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE DR ,  LANZ PAUL ,  ZANETTI GUIDO DR ,  VOGLER KARL DR

IPC: C07C51/60 ,  C07D499/00 ,  C07D499/60 ,  C07D99/22

Abstract: Novel antibiotic compounds represented by the formula -CH2-COO-CH-CO-NH- ¦¦ (R)nT S ANGLE CH3 CH--CHC ANGLE ¦¦¦CH3 C---N---CH PARALLEL ¦ OCOOH wherein R is halogen, lower alkyl, lower alkoxy, lower alkylamino, di-lower alkylamino or lower alkanoylamino, n is an integer of 0-2 and T is a C2-C5 alkyl group, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND HYDRATES OF SUCH SALTS A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREOF ARE DISCLOSED.

公开(公告)号：AU3735371A

公开(公告)日：1973-06-28

申请号：AU3735371

申请日：1971-12-24

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  QUITT PETER ,  VOGLER KARL ,  LANZ PAUL

IPC: C07D499/12 ,  A61K31/431 ,  A61P31/04 ,  C07D207/28 ,  C07D207/34 ,  C07D213/78 ,  C07D213/79 ,  C07D213/89 ,  C07D215/48 ,  C07D215/50 ,  C07D217/26 ,  C07D231/14 ,  C07D233/90 ,  C07D239/54 ,  C07D239/557 ,  C07D261/18 ,  C07D263/34 ,  C07D277/56 ,  C07D285/06 ,  C07D307/68 ,  C07D309/12 ,  C07D333/38 ,  C07D499/00 ,  C07D499/56 ,  C07D499/60 ,  A61K21/00 ,  C07D99/16

Abstract: Compounds represented by the following formula WHEREIN A is a substituted or unsubstituted heterocyclic radical and T is a C2-C5 alkyl, alkenyl, cycloproplymethyl, cyclobutylmethyl or cyclopentyl group A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREFOR ARE DISCLOSED. These compounds are useful antibiotics.

公开(公告)号：DK141966B

公开(公告)日：1980-07-28

申请号：DK27072

申请日：1972-01-19

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  QUITT PETER ,  VOGLER KARL ,  LANZ PAUL

IPC: C07D499/12 ,  A61K31/431 ,  A61P31/04 ,  C07D207/28 ,  C07D207/34 ,  C07D213/78 ,  C07D213/79 ,  C07D213/89 ,  C07D215/48 ,  C07D215/50 ,  C07D217/26 ,  C07D231/14 ,  C07D233/90 ,  C07D239/54 ,  C07D239/557 ,  C07D261/18 ,  C07D263/34 ,  C07D277/56 ,  C07D285/06 ,  C07D307/68 ,  C07D309/12 ,  C07D333/38 ,  C07D499/00 ,  C07D499/56 ,  C07D499/60

Abstract: Compounds represented by the following formula WHEREIN A is a substituted or unsubstituted heterocyclic radical and T is a C2-C5 alkyl, alkenyl, cycloproplymethyl, cyclobutylmethyl or cyclopentyl group A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREFOR ARE DISCLOSED. These compounds are useful antibiotics.