公开(公告)号：US3433779A

公开(公告)日：1969-03-18

申请号：US3433779D

申请日：1964-09-25

Applicant: HOFFMANN LA ROCHE

Inventor： VOGLER KARL

IPC: A61K38/00 ,  C07K1/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/068 ,  C07K5/083 ,  C07K5/09 ,  C07C101/24 ,  A61K27/00 ,  C07C103/52

CPC classification number: C07K5/0815 ,  A61K38/00 ,  C07K1/02 ,  C07K5/06069 ,  C07K5/06078 ,  C07K5/06086 ,  C07K5/0806

公开(公告)号：US3900464A

公开(公告)日：1975-08-19

申请号：US31872872

申请日：1972-12-27

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  LANZ PAUL ,  QUITT PETER ,  VOGLER KARL ,  VOGLER HEIR BY FRANZISKA ,  VOGLER HEIR BY NIKLAUS E ,  VOGLER HEIR BY HEINRICH

IPC: C07D207/32 ,  C07D207/327 ,  C07D209/18 ,  C07D213/55 ,  C07D257/04 ,  C07D307/54 ,  C07D333/24 ,  C07D499/00 ,  C07D499/60 ,  C07D499/46

CPC classification number: C07D207/327 ,  C07D209/18 ,  C07D213/55 ,  C07D257/04 ,  C07D307/54 ,  C07D333/24 ,  C07D499/00 ,  Y02P20/55

Abstract: Novel antibiotic compounds represented by the formula

wherein R is a furyl, pyrrolyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, pyridyl, pyrimidinyl, tetrazolyl or indolyl radical which can be substituted with halogen, C1-C3-alkyl, C1-C3alkoxy or C1-C3-alkylthio and T is a C2-C5-alkyl group, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND HYDRATES OF SUCH SALTS, A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREOF ARE DISCLOSED.

公开(公告)号：US3917584A

公开(公告)日：1975-11-04

申请号：US31873872

申请日：1972-12-27

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  LANZ PAUL ,  VOGLER KARL ,  ZANETTI GUIDO

IPC: C07C51/60 ,  C07D499/00 ,  C07D499/60 ,  C07D499/44

CPC classification number: C07D499/00 ,  C07C51/60 ,  Y02P20/55 ,  C07C59/64

Abstract: Novel antibiotic compounds represented by the formula

wherein R is halogen, lower alkyl, lower alkoxy, lower alkylamino, di-lower alkylamino or lower alkanoylamino, n is an integer of 0-2 and T is a C2-C5 alkyl group, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND HYDRATES OF SUCH SALTS A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREOF ARE DISCLOSED.

Abstract translation: 由式-CH2-COO-CH-CO-NH- ||（R）nT S ANGLE CH3 CH-CHC ANGLE |||CH3 C --- N --- CH PARALLEL | OCOOH表示的新型抗生素化合物其中R 是卤素，低级烷基，低级烷氧基，低级烷基氨基，二低级烷基氨基或低级烷酰基氨基，n是0-2的整数，T是C2-C5烷基，其药学上可接受的盐及其等价物的方法 他们的准备和新闻中介被披露。

公开(公告)号：US3455911A

公开(公告)日：1969-07-15

申请号：US3455911D

申请日：1966-12-28

Applicant: HOFFMANN LA ROCHE

Inventor： VOGLER KARL

IPC: A61K31/18 ,  C07C311/37 ,  C07D239/69 ,  C07D51/44 ,  A61K27/00 ,  C07D85/24

CPC classification number: C07D239/69 ,  A61K31/18 ,  C07C311/37 ,  Y02P20/55

公开(公告)号：US3886142A

公开(公告)日：1975-05-27

申请号：US31873672

申请日：1972-12-27

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  LANZ PAUL ,  VOGLER KARL ,  ZANETTI GUIDO

IPC: B25C5/02 ,  B25C5/06 ,  C07C51/60 ,  C07D499/00 ,  C07D499/60 ,  F16B15/04 ,  C07D99/16

CPC classification number: F16B15/04 ,  B25C5/0257 ,  B25C5/06 ,  C07C51/60 ,  C07D499/00 ,  Y10S411/92 ,  Y10S514/962 ,  Y10T29/49833 ,  C07C59/70

Abstract: WHEREIN R is halogen, lower alkyl, lower alkoxy, nitro, lower alkoxy-lower alkyl, dilower alkylamino, lower alkyl sulfonylamido, bis-lower alkylsulfonyl amido or lower alkanoyl amido, n is an integer of 0-2 and T is a C2-C5 alkyl group, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND HYDRATES OF SUCH SALTS, A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREFOR ARE DISCLOSED.
Novel antibiotic compounds represented by the formula

D R A W I N G

Abstract translation: 由式WHEREIN R表示的新型抗生素化合物是卤素，低级烷基，低级烷氧基，硝基，低级烷氧基 - 低级烷基，二元烷基氨基，低级烷基磺酰氨基，双 - 低级烷基磺酰基酰氨基或低级烷酰氨基，n是0〜 2和T是C 2 -C 5烷基，其药学上可接受的盐及其水合物，其制备和新型中间体的方法被公开。

公开(公告)号：US3627884A

公开(公告)日：1971-12-14

申请号：US3627884D

申请日：1970-07-22

Applicant: HOFFMANN LA ROCHE

Inventor： VOGLER KARL

IPC: A61K31/195 ,  A61K27/00

CPC classification number: A61K31/195

Abstract: A method of inhibiting and controlling the growth of bacteria which comprises contacting said bacteria with an antibacterially effective amount of a long chain aliphatic ester selected from the group consisting of L-lysine-n-dodecylester L-lysine-ntetradecylester and acid addition salts thereof is described.

公开(公告)号：US3592804A

公开(公告)日：1971-07-13

申请号：US3592804D

申请日：1968-11-19

Applicant: HOFFMANN LA ROCHE

Inventor： QUITT PETER ,  VOGLER KARL

IPC: C07D277/06 ,  A61K27/00 ,  C07C103/52 ,  C07D91/18

CPC classification number: C07D277/06 ,  Y02P20/55 ,  Y10S514/922

Abstract: PENICILLIOC ACID DERIVATIVES OF THE FORMULA

(4-(HOOC-),5-(CH3-)2-THIAZOLIDIN-2-YL)-CH(-NH-CO-R)-CO-NH-

(CH2)N-CH(-NH-R1)-COOH

WHEREIN N IS AN INTEGER FROM 2 TO 4 AND R IN PREFERRED EMBODIMENTS IS BENZYL, PHENOXYMETHYL OR ALLYLTHIOMETHYL AND R1 IS HYDROGEN OR LOWER ACYL AND METHODS FOR THEIR PREPARATION ARE DISCLOSED. THESE PENICILLOIC ACID DERIVATIVES ARE USEFUL FOR INHIBITING ALLERGIC REACTIONS WHICH OCCUR ON ADMINISTRATION OF PENICILLINS.

公开(公告)号：RO70672A

公开(公告)日：1982-08-17

申请号：RO6939572

申请日：1972-01-14

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  QUITT PETER ,  VOGLER KARL ,  LANZ PAUL

IPC: C07D499/12 ,  A61K31/431 ,  A61P31/04 ,  C07D207/28 ,  C07D207/34 ,  C07D213/78 ,  C07D213/79 ,  C07D213/89 ,  C07D215/48 ,  C07D215/50 ,  C07D217/26 ,  C07D231/14 ,  C07D233/90 ,  C07D239/54 ,  C07D239/557 ,  C07D261/18 ,  C07D263/34 ,  C07D277/56 ,  C07D285/06 ,  C07D307/68 ,  C07D309/12 ,  C07D333/38 ,  C07D499/00 ,  C07D499/56 ,  C07D499/60 ,  C07D499/52

Abstract: Compounds represented by the following formula WHEREIN A is a substituted or unsubstituted heterocyclic radical and T is a C2-C5 alkyl, alkenyl, cycloproplymethyl, cyclobutylmethyl or cyclopentyl group A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREFOR ARE DISCLOSED. These compounds are useful antibiotics.

公开(公告)号：NO138142B

公开(公告)日：1978-04-03

申请号：NO79072

申请日：1972-03-10

Applicant: HOFFMANN LA ROCHE

Inventor： QUITT PETER ,  VOGLER KARL ,  WECK ALAIN DE

IPC: A61K31/43 ,  C07D277/06 ,  C07D277/04

公开(公告)号：CA529082A

公开(公告)日：1956-08-14

申请号：CA529082D

Applicant: HOFFMANN LA ROCHE

Inventor： VOGLER KARL