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    PROCESS FOR PREPARING TRICYCLIC COMPOUNDS
    1.
    发明授权
    PROCESS FOR PREPARING TRICYCLIC COMPOUNDS 失效

    公开(公告)号：KR810001155B1

    公开(公告)日：1981-09-22

    申请号：KR780002277

    申请日：1978-07-24

    Applicant: HOFFMANN LA ROCHE

    Inventor： KAISER A ,  CHODNEDAR MADHUKAR SUBRAYA

    IPC: C07D487/04

    Abstract: Quinazoline derivs. [I; R1,R2 = H, halogen, lower alkyl, hydroxy, lower alkoxy, hydroxy-(lower alkyl), (lower alkoxy)-(lower alkyl), Ph, Phenoxy, amino, lower alkylamino, di(lower alkyl)amino; R3 = H, lower alkyl, Ph; R4 = lower alkyl, hydroxy-(lower alkyl), (lower alkoxy)-(lower alkyl), aryl-(lower alkyl), aryl , useful as blood platelet aggregation inhibitor were prepd. by the reaction of II and cyanogen bromide, or III(R5 = lower alkyl) and ammonia.

    Amino acid derivatives
    4.
    发明授权
    Amino acid derivatives 失效
    氨基酸衍生物

    公开(公告)号：US3725470A

    公开(公告)日：1973-04-03

    申请号：US3725470D

    申请日：1970-05-08

    Applicant: HOFFMANN LA ROCHE

    Inventor： BRETSCHNEIDER H ,  KAISER A ,  KRAFT HOHENLOHE OEHRINGEN

    IPC: C07C227/16 ,  C07C65/02 ,  C07C101/00

    CPC classification number: C07C227/16

    Abstract: A process for preparing 3,4-dihydroxy phenylalanine derivatives including novel 3,4-dihydroxy phenylalanine derivatives wherein the phenyl ring contains an additional substituent which can be hydroxy, lower alkyl, lower alkoxy, halogen, nitro or amino groups from a mono hydroxy phenyl alanine including novel intermediates in this process. The novel 3,4-dihydroxyphenylalanine derivatives are useful as blood pressure lowering agents and as anti-parkinson agents.

    Abstract translation: 一种制备包括新型3,4-二羟基苯丙氨酸衍生物的3,4-二羟基苯丙氨酸衍生物的方法，其中苯环含有另外的取代基，其可以是羟基，低级烷基，低级烷氧基，卤素，硝基或氨基， 丙氨酸，包括这个过程中的新型中间体。 新型3,4-二羟基 - 苯丙氨酸衍生物可用作降血压剂和抗帕金森剂。

    N-substituted phenylalanine derivatives
    6.
    发明授权
    N-substituted phenylalanine derivatives 失效
    N-取代的苯乙胺衍生物

    公开(公告)号：US3852338A

    公开(公告)日：1974-12-03

    申请号：US19148671

    申请日：1971-10-21

    Applicant: HOFFMANN LA ROCHE

    Inventor： KAISER A ,  KOCH W ,  SCHEER M ,  WOLCKE U

    IPC: C07C235/12 ,  C07C275/24 ,  C07F5/04 ,  C07C101/08

    CPC classification number: C07C275/24 ,  C07C235/12 ,  C07F5/04

    Abstract: Phenylalanine derivatives which are N-substituted with a carbonyl, thio, or sulfonyl substituent useful as hypotensive, anti-pyretic and anti-parkinson agents and processes for their preparation from phenylalanine including intermediates in these processes.

    Abstract translation: 用作低血压，抗热解和抗帕金森病药物的羰基，硫代或磺酰基取代基被N-取代的苯丙氨酸衍生物及其制备方法，包括这些方法中的中间体。

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