公开(公告)号：KR800000060B1

公开(公告)日：1980-01-29

申请号：KR750001881

申请日：1975-08-25

Applicant: HOFFMANN LA ROCHE

Inventor： PFISTER R ,  HROMATKA O ,  ZELLER P ,  BINDER D

IPC: C07D497/02

Abstract: Thienothiazine derivs. (I; A formed B or C with two carbons, R1 = lower alkyl, R2 = aromatic heterocyclic residues, Ph, R3, R4 = H, lower alkyl) useful as antiphlogistic, anodyne, and antirheumatic, were prepd. by treating I(NHR2 = OR, R - lower alkyl) with amine (III), decyclizing IV, lower alkylizing I(R' = H), reacting I(OH = O, COHNR2 = H2) with isocyanate (O = C = N-R2) in the presence of strong base, or hydrolizing enamines (I; OH = NR5R6, R5, R6 = lower alkyl).

公开(公告)号：KR790000166B1

公开(公告)日：1979-03-24

申请号：KR740001428

申请日：1974-02-08

Applicant: HOFFMANN LA ROCHE

Inventor： ZELLER P ,  HROMATKA O ,  BINDER D ,  HELLERBACH J

Abstract: Psychotropic thienotriazolodiazepines (I; n = o or 1, R1 = H, cl, alkyl, alkanoyl, amino group R2 = phenyl, o-halophenyl, o-nitrophenyl, R3 = H, hydroxy, alkoxycarbonyl, alkanoyloxy group, R4 = H, alkyl, alkanoyl, hydroxyalkyl, mercaptoalkyl, alkoxycarbonyl, alkylthioalkyl, alkylcarbonyloxyalkyl group) were prepd. by cyclizing the hydrazinothienodiazepines.I,2-chloro-4-(o-chlorophenyl)-9-methyl-6H-thieno-{3,2-f -s-triazolo [4,3-al [1,4 diazepine showed ED50= 1 mg/kg orally in the chimney test of mouse.

公开(公告)号：US3711543A

公开(公告)日：1973-01-16

申请号：US3711543D

申请日：1970-06-04

Applicant: HOFFMANN LA ROCHE

Inventor： BOLLAG W ,  GUTMANN H ,  LANGEMANN A ,  MULLER M ,  HEGEDUS B ,  KAISER A ,  ZELLER P

IPC: C07C51/60 ,  C07C233/00 ,  C07C243/38 ,  C07D213/81 ,  C07D213/82 ,  C07D261/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  C07C127/16

CPC classification number: C07D213/81 ,  C07C51/60 ,  C07C233/00 ,  C07C243/00 ,  C07C243/38 ,  C07D213/82 ,  C07D261/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  Y02P20/55 ,  C07C63/10

Abstract: Benzene-ring substituted (2-methylhydrazino)-methyl-benzene compounds and intermediates therefore are described. The former compounds are useful as cytostatic agents and, particularly, inhibit the growth of transplantable tumors in both mice and rats. Thus, they are active, for example, against Walker tumors, Ehrlich carcinoma and Ehrlich ascites carcinoma.

公开(公告)号：US3795678A

公开(公告)日：1974-03-05

申请号：US3795678D

申请日：1972-11-21

Applicant: HOFFMANN LA ROCHE

Inventor： BOLLAG W ,  GUTMANN H ,  HEGEDUS B ,  MULLER M ,  ZELLER P ,  KAISER A ,  LANGEMANN A

IPC: C07C51/60 ,  C07C233/00 ,  C07C243/38 ,  C07D213/81 ,  C07D213/82 ,  C07D261/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  C07D31/44

CPC classification number: C07D213/81 ,  C07C51/60 ,  C07C233/00 ,  C07C243/00 ,  C07C243/38 ,  C07D213/82 ,  C07D261/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  Y02P20/55 ,  C07C63/10

Abstract: BENZENE-RING SUBSTITUTED (2-METHYLHYDRAZINO)-METHYLBENZENE COMPOUNDS AND INTERMEDIATES THEREFOR ARE DESCRIBED. THE FORMER COMPOUNDS ARE USEFUL AS CYTOSTATIC AGENTS AND, PARTICUARLY, INHIBIT THE GROWTH OF TRANSPLANTABLE TUMORS IN BOTH MICE AND RATS. THUS, THEY ARE ACTIVE, FOR EXAMPLE, AGAINST WALKER TUMORS, EHRLICH CARCINOMA AND EHRLICH ASCITES CARCINOMA.

公开(公告)号：US3830840A

公开(公告)日：1974-08-20

申请号：US30862872

申请日：1972-11-21

Applicant: HOFFMANN LA ROCHE

Inventor： ZELLER P ,  LANGEMANN A ,  MULLER M ,  HEGEDUS B ,  KAISER A ,  BOLLAG W ,  GUTMANN H

IPC: C07C311/02 ,  C07C143/74

CPC classification number: C07C243/00

Abstract: BEBZENE-RING SUBSTITUTED (2-METHYLHYDRAZINO)-METHYLBENZENE COMPOUNDS AND INTERMEIATES THEREOF ARE DESCRIBED. THE FORMED COMPOUNDS ARE USEFUL AS CYTOSTATIC AGENTS AND, PARTICULARLY, INIBIT THE ROOWTH OF TRANSPLANTALE TUMORS IN BOTH MICE AND RATS. THUS, THENY ARE ACTIVE FOR EXAMPLE, AGAINST WALKER TUMORS, ERLICH CARCINMA AND ERILICH ASCITES CARINOMA.

公开(公告)号：US3824288A

公开(公告)日：1974-07-16

申请号：US30862772

申请日：1972-11-21

Applicant: HOFFMANN LA ROCHE

Inventor： ZELLER P ,  LANGEMANN A ,  MULLER M ,  HEGEDUS B ,  KAISER A ,  BOLLAG W ,  GUTMANN H

IPC: C07C233/00 ,  C07C243/38 ,  C07C129/08

CPC classification number: C07C243/38 ,  C07C233/00 ,  C07C243/00

Abstract: BENZENE-RING SUBSTITUTED (2-METHYLHYDRAZINO)-METHYLBENZENE COMPOUNDS AND INTERMEDIATES THEREFOR ARE DESCRIBED. THE FORMER COMPOUNDS ARE USEFUL AS CYTOSTATIC AGENTS AND, PARTICULARLY, IN HIBIT THE GROWTH OF TRANSPLANTABLE TOUMORS IN BOTH MICE AND RATS. THUS, THEY ARE ACTIVE, FOR EXAMPLE,AGAINST WALKER TUMORS, EHRILICH CARCINOMA AND EHRILICH ASCITES CARCINOMA.

公开(公告)号：YU22874A

公开(公告)日：1982-06-30

申请号：YU22874

申请日：1974-01-30

Applicant: HOFFMANN LA ROCHE

Inventor： HELLERBACH J ,  ZELLER P ,  BINDER D ,  HROMATIKA O

IPC: A61K31/55 ,  A61K31/5517 ,  A61P25/08 ,  A61P25/20 ,  C07D333/36 ,  C07D495/04 ,  C07D495/14 ,  C07D495/00

公开(公告)号：NZ188320A

公开(公告)日：1981-01-23

申请号：NZ18832078

申请日：1978-09-01

Applicant: HOFFMANN LA ROCHE

Inventor： HROMOTKA O ,  ZELLER P ,  PFISTER R ,  BINDER D

IPC: A61K31/54 ,  A61P7/02 ,  A61P25/04 ,  A61P29/00 ,  C07D333/34 ,  C07D333/38 ,  C07D513/04

公开(公告)号：ZA7804624B

公开(公告)日：1979-08-29

申请号：ZA7804624

申请日：1978-08-15

Applicant: HOFFMANN LA ROCHE

Inventor： ZELLER P ,  PFISTER R ,  HROMATKA O ,  BINDER D

IPC: A61K31/54 ,  A61P7/02 ,  A61P25/04 ,  A61P29/00 ,  C07D333/34 ,  C07D333/38 ,  C07D513/04 ,  C07D ,  A61K

CPC classification number: C07D513/04 ,  C07D333/34 ,  C07D333/38

公开(公告)号：LU78009A1

公开(公告)日：1979-05-23

申请号：LU78009

申请日：1977-08-22

Applicant: HOFFMANN LA ROCHE

Inventor： BINDER D ,  HROMATKA O ,  PFISTER R ,  ZELLER P

IPC: A61K31/54 ,  A61P7/02 ,  A61P25/04 ,  A61P29/00 ,  C07D333/34 ,  C07D333/38 ,  C07D513/04 ,  C07D ,  A61K