公开(公告)号：US3875182A

公开(公告)日：1975-04-01

申请号：US33539673

申请日：1973-02-23

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER HERMANN ,  KLOTZER WILHELM ,  BADER GUNTHER ,  LUTZ AUGUST

IPC: A61K31/415 ,  A61P3/08 ,  C07D207/22 ,  C07D403/12 ,  C07D487/14 ,  C07D49/18

CPC classification number: C07D403/12 ,  C07D207/22 ,  Y10S514/866

Abstract: 3-Methyl-N-(1-pyrrolin-2-yl)-pyrazole-5-carboxamides and processes for making same. Such compounds lower blood sugar and, hence, are useful as antidiabetic agents.

Abstract translation: 3-甲基-N-（1-吡咯啉-2-基） - 吡唑-5-甲酰胺及其制备方法。 这些化合物降低血糖，因此可用作抗糖尿病药。

公开(公告)号：US3665012A

公开(公告)日：1972-05-23

申请号：US3665012D

申请日：1969-08-01

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER HERMANN ,  KLOTZER WILHELM ,  FRANZMAIR RUDOLF

IPC: C07D207/22 ,  C07D207/26 ,  C07D27/04

CPC classification number: C07D207/26 ,  C07D207/22 ,  Y10S514/866

Abstract: Novel 2-iminopyrrolidines substituted in the 1-position are prepared from 2-amino- Delta ''-pyrrolines. The novel pyrrolidines are useful as anti-diabetic and hypoglycemic agents since they effect a lowering of the blood sugar content in warm blooded animals.

公开(公告)号：US3564010A

公开(公告)日：1971-02-16

申请号：US70748468

申请日：1968-02-23

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER HERMANN ,  FRANZMAIR RUDOLF ,  KLOTZER WILHELM ,  SCHMIDT BELA

IPC: C07D207/22 ,  C07D207/38 ,  C07D27/14

CPC classification number: C07D207/22 ,  C07D207/38 ,  Y10S514/884

Abstract: GUANIDINO OR UREIDO OR THIOUREIDO PYRROLINES (A) PREPARED FROM 2-AMINO-$1-PYRROLINES. (B). BOTH (A) AND (B) LOWER THE BLOOD SUGAR CONTENT IN WARM BLOODED ANIMALS; HENCE, ARE USEFUL AS HYPOLGLYCEMIC AGENTS.

公开(公告)号：CS276093B6

公开(公告)日：1992-04-15

申请号：CS89188

申请日：1988-02-12

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  MONTAVON MARE ,  MUSSNER RENATE ,  SINGEWALD NICOLAS

IPC: C07D233/56 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00 ,  C07D413/04 ,  C07D401/04 ,  C07D403/04

Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

公开(公告)号：AU6107873A

公开(公告)日：1975-04-10

申请号：AU6107873

申请日：1973-10-05

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  BRETSCHNEIDER HERMANN ,  FLIRI HANS

IPC: C07D239/46 ,  C07D239/52 ,  C07D239/54 ,  C07D239/56 ,  C07D239/69 ,  A61K27/00 ,  C07D51/30

Abstract: 1396840 Sulphanilamides F HOFFMANNLA ROCHE & CO AG 19 Oct 1973 [20 Oct 1972] 48787/73 Heading C2C Novel compounds (I) where R is alkyl, allyl or alkoxyalkyl, are made (a) by reacting a compound (II) (R 1 is a leaving atom or group) with a sulphanilamide alkali metal salt, (b) by saponifying compounds (III) and (c) by reducing compounds (IV). The invention also comprises novel compounds (III) and (IV). Pharmaceutical preparations useful for controlling bacterial infections contain (I) as active ingredient. Administration may be orally or parenterally.

公开(公告)号：CA824676A

公开(公告)日：1969-10-07

申请号：CA824676D

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  BRETSCHNEIDER HERMANN ,  FITZ EGON

公开(公告)号：AU613349B2

公开(公告)日：1991-08-01

申请号：AU1353288

申请日：1988-03-21

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  MONTAVON MARC ,  MUSSNER RENATE ,  SINGEWALD NICOLAS

IPC: C07D233/56 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00

Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

公开(公告)号：AU1353288A

公开(公告)日：1988-09-22

申请号：AU1353288

申请日：1988-03-21

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  MONTAVON MARC ,  MUSSNER RENATE ,  SINGEWALD NICOLAS

IPC: C07D233/56 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00

Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

公开(公告)号：CA856268A

公开(公告)日：1970-11-17

申请号：CA856268D

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER HERMANN ,  KLOTZER WILHELM ,  SCHMIDT BELA ,  FRANZMAIR RUDOLF

公开(公告)号：CA643369A

公开(公告)日：1962-06-19

申请号：CA643369D

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  BRETSCHNEIDER HERMANN