公开(公告)号：CS276093B6

公开(公告)日：1992-04-15

申请号：CS89188

申请日：1988-02-12

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  MONTAVON MARE ,  MUSSNER RENATE ,  SINGEWALD NICOLAS

IPC: C07D233/56 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00 ,  C07D413/04 ,  C07D401/04 ,  C07D403/04

Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

公开(公告)号：AU613349B2

公开(公告)日：1991-08-01

申请号：AU1353288

申请日：1988-03-21

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  MONTAVON MARC ,  MUSSNER RENATE ,  SINGEWALD NICOLAS

IPC: C07D233/56 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00

Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

公开(公告)号：AU1353288A

公开(公告)日：1988-09-22

申请号：AU1353288

申请日：1988-03-21

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  MONTAVON MARC ,  MUSSNER RENATE ,  SINGEWALD NICOLAS

IPC: C07D233/56 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00

Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

公开(公告)号：NZ223862A

公开(公告)日：1990-08-28

申请号：NZ22386288

申请日：1988-03-11

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  MONTAVON MARC ,  MUSSNER RENATE ,  SINGEWALD NICHOLAS

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/56 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00 ,  C07D413/04 ,  A61K31/535

Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

公开(公告)号：CS8800891A2

公开(公告)日：1990-09-12

申请号：CS89188

申请日：1988-02-12

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  MONTAVON MARC ,  MUSSNER RENATE ,  SINGEWALD NICOLAS

IPC: C07D233/56 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00

Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

公开(公告)号：AU598459B2

公开(公告)日：1990-06-28

申请号：AU5642986

申请日：1986-04-21

Applicant: HOFFMANN LA ROCHE

Inventor： KARPITSCHKA EVA MARIA ,  KLOTZER WILHELM ,  LINK HELMUT ,  MONTAVON MARC ,  MUSSNER RENATE

IPC: C07D233/54 ,  C07D233/56 ,  C07D521/00 ,  C07D233/64 ,  C07D409/14 ,  A61K31/415 ,  C07D233/61

Abstract: Compounds of the formula I wherein the various substituents are defined hereinbelow and the pharmaceutically acceptable acid addition salts thereof, possess pharmacological properties. In particular, they possess antibacterial, antimycotic, protozoacidal and/or anthelmintic properties.

公开(公告)号：PT87025A

公开(公告)日：1988-04-01

申请号：PT8702588

申请日：1988-03-18

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  MONTAVON MARC ,  MUSSNER RENATE ,  SINGEWALD NICOLAS

IPC: A61K31/415 ,  A61K31/4164 ,  C07D233/56 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00 ,  C07D233/54 ,  A61K31/41

Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

公开(公告)号：AU597974B2

公开(公告)日：1990-06-14

申请号：AU7259487

申请日：1987-05-07

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  SCHIESTL WERNER ,  LINK HELMUT ,  MUSSNER RENATE ,  SINGEWALD NICOLAS

IPC: C07D401/06 ,  A61K31/415 ,  A61P17/00 ,  A61P31/04 ,  A61P33/02 ,  A61P33/10 ,  C07D233/54 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D233/64 ,  C07D233/70 ,  C07D233/84 ,  C07D233/88 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06 ,  A61K31/535 ,  A61K31/54 ,  A61K31/445 ,  A61K31/495

Abstract: The imidazolium compounds of the formula I wherein the various substituents are defined hereinbelow and their pharmaceutically acceptable acid addition salts, which possess valuable pharmacological properties are described. In particular, they possess antibacterial, antimycotic, protozoacidal and/or anthelmintic properties and are especially active against parasitic protozoa and worms. The compounds of formula I can be prepared according to known methods.

公开(公告)号：AU7259487A

公开(公告)日：1987-11-19

申请号：AU7259487

申请日：1987-05-07

Applicant: HOFFMANN LA ROCHE

Inventor： KLOTZER WILHELM ,  LINK HELMUT ,  MUSSNER RENATE ,  SCHIESTL WERNER ,  SINGEWALD NICOLAS

IPC: C07D401/06 ,  A61K31/415 ,  A61P17/00 ,  A61P31/04 ,  A61P33/02 ,  A61P33/10 ,  C07D233/54 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D233/64 ,  C07D233/70 ,  C07D233/84 ,  C07D233/88 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06 ,  A61K31/535 ,  A61K31/54 ,  A61K31/445 ,  A61K31/495

Abstract: The imidazolium compounds of the formula I wherein the various substituents are defined hereinbelow and their pharmaceutically acceptable acid addition salts, which possess valuable pharmacological properties are described. In particular, they possess antibacterial, antimycotic, protozoacidal and/or anthelmintic properties and are especially active against parasitic protozoa and worms. The compounds of formula I can be prepared according to known methods.

公开(公告)号：AU5642986A

公开(公告)日：1986-10-30

申请号：AU5642986

申请日：1986-04-21

Applicant: HOFFMANN LA ROCHE

Inventor： KARPITSCHKA EVA MARIA ,  KLOTZER WILHELM ,  LINK HELMUT ,  MONTAVON MARC ,  MUSSNER RENATE

IPC: C07D233/54 ,  C07D233/56 ,  C07D521/00 ,  A61K31/415 ,  C07D233/64 ,  C07D409/14

Abstract: Compounds of the formula I wherein the various substituents are defined hereinbelow and the pharmaceutically acceptable acid addition salts thereof, possess pharmacological properties. In particular, they possess antibacterial, antimycotic, protozoacidal and/or anthelmintic properties.