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公开(公告)号：JP2004239904A
公开(公告)日：2004-08-26
申请号：JP2004021784
申请日：2004-01-29
Inventor： NOETZEL SIEGFRIED , BOGARDI JEAN-PHILIPPE , MANGOLD DIETER
CPC classification number: B01L3/502746 , B01L3/502753 , B01L2200/10 , B01L2300/0681 , B01L2300/0809 , B01L2300/0867 , G01N33/558 , G01N33/721 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575
Abstract: PROBLEM TO BE SOLVED: To conduct blood analysis at a low cost, with little influence on the user, and which has reduced reagent consumption. SOLUTION: The inspection element for analysis is preferably for blood analysis, especially by single-use simple inspection and includes a substrate (12), having a path structure for microfluids (14) which delivers a blood sample to one or more analysis parts (20, 22) from an applied part (18). The path structure (14) can load the blood sample and comprises a dilution path (24), which has a separation means (36) for retaining particulate blood components, and a sample path (26), which transports aliquots of the blood sample to be diluted and merges with the dilution path (24) at a mixing part (40). COPYRIGHT: (C)2004,JPO&NCIPI
Abstract translation: 要解决的问题：以低成本进行血液分析，对用户的影响很小，并且降低了试剂消耗。 解决方案：用于分析的检查元件优选用于血液分析，特别是通过一次性简单检查，并且包括具有用于将血液样品递送到一个或多个分析的微流体（14）的路径结构的基底（12） 部件（20,22）。 路径结构（14）可以装载血液样本并且包括稀释路径（24），该稀释路径具有用于保持颗粒状血液成分的分离装置（36）和将血液样本的等分试样运送到 在混合部分（40）处稀释并与稀释路径（24）合并。 版权所有（C）2004，JPO＆NCIPI
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公开(公告)号：JP2008216269A
公开(公告)日：2008-09-18
申请号：JP2008154841
申请日：2008-06-13
Inventor： NOETZEL SIEGFRIED , BOGARDI JEAN-PHILIPPE , MANGOLD DIETER
CPC classification number: B01L3/502746 , B01L3/502753 , B01L2200/10 , B01L2300/0681 , B01L2300/0809 , B01L2300/0867 , G01N33/558 , G01N33/721 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575
Abstract: PROBLEM TO BE SOLVED: To conduct a blood test which is inexpensive, reduces influence from a user as much as possible, and suppresses reagent consumption. SOLUTION: An analytical test element for blood analyses especially by a single time simple test preferably comprises a substrate body 12 having a channel structure 14 for a micro fluid for flowing and transporting a blood sample from an application site 18 to at least one analytical site 20, 22. The channel structure 14 has a dilution channel 24 that can be loaded with the blood sample and is provided with a separation means 36 for retaining corpuscular blood components, and has a sample channel 26 which conveys a blood sample aliquot to be diluted and joins the dilution channel 24 at a mixing site 40. COPYRIGHT: (C)2008,JPO&INPIT
Abstract translation: 要解决的问题：进行廉价的血液检查，尽可能地减少使用者的影响，抑制试剂消耗。 解决方案：用于血液分析的分析测试元件，特别是通过单次简单测试，优选地包括具有用于微流体的通道结构14的基底体12，用于将血液样品从施用部位18流动并输送到至少一个 分析部位20,22。通道结构14具有稀释通道24，该稀释通道24可以装载血液样品，并且设置有用于保持红细胞血液成分的分离装置36，并且具有样品通道26，其将血液样品等分试样输送到 稀释并在混合部位40加入稀释通道24.版权所有（C）2008，JPO＆INPIT
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Patent Agency Ranking
公开(公告)号：JP2004177404A
公开(公告)日：2004-06-24
申请号：JP2003378957
申请日：2003-11-07
Inventor： FREY GUENTER , LADIGES NORBERT , NOETZEL SIEGFRIED , ROESICKE BERND
CPC classification number: B01L3/5023 , B01L9/52 , B01L2300/0681 , B01L2300/0825 , B01L2400/0406 , B01L2400/0481 , G01N33/491 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
Abstract: PROBLEM TO BE SOLVED: To provide an apparatus for acquiring the separation of pure plasma on a microlitter-scale from whole blood in a short time, and a method thereof. SOLUTION: The apparatus for separating and delivering plasma comprises an analyzing element, which comprises a first region and a second region, and a delivering unit. The separating element is placed in the apparatus so that a user can add blood to the first region. The method having two independent successive steps is conducted; when blood is added to the first region of the element, the plasma is transferred to the second region of the element, and the blood cell components are substantially completely retained in the first region of the element. The delivering unit acts substantially on the second region of the element without influencing the first region of the element so that, after the separation of the plasma, the separated plasma is discharged from the second region of the element and is delivered from an outlet of the apparatus. COPYRIGHT: (C)2004,JPO
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公开(公告)号：CA2456695C
公开(公告)日：2009-10-13
申请号：CA2456695
申请日：2004-02-03
Applicant: HOFFMANN LA ROCHE
Inventor： MANGOLD DIETER , BOGARDI JEAN-PHILIPPE , NOETZEL SIEGFRIED
IPC: G01N33/48 , G01N33/49 , B01L3/00 , B81B1/00 , G01N33/50 , G01N33/53 , G01N33/558 , G01N33/72 , G01N35/02 , G01N35/08
Abstract: For an analytical test element for blood analyses comprising a substrate bod y (12) having a channel structure (14) for the flow transport of a blood sample fro m an application site (18) to at least one analytical site (20, 22), the inventio n proposes that the channel structure (14) has a dilution channel (24) that can be load ed with the blood sample and is provided with separation means (36) for retaining corpuscular blood components and has a sample channel (26) which conveys a blood sample aliquot to be diluted and joins the dilution channel (24) at a mixing site (40).
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公开(公告)号：CA2448433C
公开(公告)日：2008-01-29
申请号：CA2448433
申请日：2003-11-06
Applicant: HOFFMANN LA ROCHE
Inventor： ROESICKE BERND , NOETZEL SIEGFRIED , FREY GUENTER , LADIGES NORBERT
Abstract: The invention concerns plasma separation on a microlitre scale. The method/system according to the invention is able to provide plasma in the range of several microlitres within a very short time as it is required for example in modern analyses by carrier-bound test elements. Plasma separation and plasma release is carried out in two separate consecutive steps of the method using the device according to t he invention such that haemolysis during plasma separation can be avoided despi te an accelerated procedure. The device preferably comprises a disposable unit in which the device is characterized by an economical and simple method of production.
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公开(公告)号：CA2456695A1
公开(公告)日：2004-08-07
申请号：CA2456695
申请日：2004-02-03
Applicant: HOFFMANN LA ROCHE
Inventor： BOGARDI JEAN-PHILIPPE , MANGOLD DIETER , NOETZEL SIEGFRIED
Abstract: For an analytical test element for blood analyses comprising a substrate bod y (12) having a channel structure (14) for the flow transport of a blood sample fro m an application site (18) to at least one analytical site (20, 22), the inventio n proposes that the channel structure (14) has a dilution channel (24) that can be load ed with the blood sample and is provided with separation means (36) for retaining corpuscular blood components and has a sample channel (26) which conveys a blood sample aliquot to be diluted and joins the dilution channel (24) at a mixing site (40).
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公开(公告)号：CA2448433A1
公开(公告)日：2004-05-11
申请号：CA2448433
申请日：2003-11-06
Applicant: HOFFMANN LA ROCHE
Inventor： FREY GUENTER , ROESICKE BERND , NOETZEL SIEGFRIED , LADIGES NORBERT
Abstract: The invention concerns plasma separation on a microlitre scale. The method/system according to the invention is able to provide plasma in the range of several microlitres within a very short time as it is required for example in modern analyses by carrier-bound test elements. Plasma separation and plasma release is carried out in two separate consecutive steps of the method using the device according to t he invention such that haemolysis during plasma separation can be avoided despi te an accelerated procedure. The device preferably comprises a disposable unit in which the device is characterized by an economical and simple method of production.
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