公开(公告)号：US20240337629A1

公开(公告)日：2024-10-10

申请号：US18746342

申请日：2024-06-18

Applicant: Hitachi High-Tech Corporation

Inventor： Makoto NOGAMI ,  Yusuke SHIMIZU ,  Daisuke AKIEDA ,  Kenichiro NISHIKI

IPC: G01N30/54 ,  B01D15/16 ,  G01N30/30 ,  G01N30/60

CPC classification number: G01N30/54 ,  G01N30/30 ,  G01N30/6047 ,  G01N30/6091 ,  B01D15/161 ,  G01N2030/3084

Abstract: Implemented is an analysis apparatus column oven equipped with a plurality of columns, which is capable of efficiently performing heat conduction on column basis, recognizing a column cartridge that holds a column, and being easily exchanged on column basis. The column change mechanism includes the ferrule, the movable ferrule connector, the pipe, the fastener pull, the fastener fitting, the column cartridge presser, the slide guide, the RFID reader, the fixed wall, the column changer heat insulating member, the fixed bottom plate, the receiver, and the fixed fitting. A plurality of column cartridges can be installed in the heat block, and are in contact with the column heat block to control the temperature in the column cartridges. The column cartridge is fixed between left and right column change mechanisms, and when the fixed column cartridge is opened, the column change mechanism on the left side is moved leftward and opened.

公开(公告)号：US20210011003A1

公开(公告)日：2021-01-14

申请号：US17035862

申请日：2020-09-29

Applicant: Hitachi High-Tech Corporation

Inventor： Ryosuke TAKAHASHI ,  Katsuhiro KANDA ,  Yusuke SHIMIZU

IPC: G01N33/50 ,  C12M1/00 ,  C12M1/34 ,  C12M1/32 ,  C12M3/00

Abstract: Provided is a component analysis device, which comprises an analysis unit for measuring a component fed to the plurality of containers and analyzing the component thus measured, wherein the plurality of containers are at least a first container and a second container, wherein the first container retains a first solution containing a substance that releases adhesion between multiple cells forming the liver cell tissue, and the second container retains a buffer solution, and wherein the analysis unit measures an amount of the component discharged from the liver cell tissue in the first container into the first solution and an amount of the component discharged from the liver cell tissue in the second container into the buffer solution in the second container, and analyzes an amount of the component to be discharged via a bile duct in the liver cell tissue.

公开(公告)号：US20240192182A1

公开(公告)日：2024-06-13

申请号：US18286499

申请日：2022-02-03

Applicant: Hitachi High-Tech Corporation

Inventor： Yu IIJIMA ,  Yusuke SHIMIZU ,  Shuhei YAMAMURA ,  Yushi HARADA

IPC: G01N30/60 ,  G01N30/02 ,  G01N30/46

CPC classification number: G01N30/6043 ,  G01N30/466 ,  G01N2030/027

Abstract: An analyzer capable of preventing unintended removal of a separation column is provided. A liquid chromatograph includes: a plurality of separation columns, and that are connected in parallel and removable; a plurality of analysis flow passages that are respectively connected to the plurality of separation columns and configured to allow a sample to flow through each of the plurality of separation columns; a lock mechanism that is configured to restrict removal of the separation columns and other than the separation column to be removed; and a control device that is configured to control the lock mechanism.

公开(公告)号：US20240011955A1

公开(公告)日：2024-01-11

申请号：US18037808

申请日：2021-12-07

Applicant: Hitachi High-Tech Corporation

Inventor： Yusuke SHIMIZU ,  Takayuki SUGIME ,  Sho IWASA

IPC: G01N30/60 ,  B01D15/18

CPC classification number: G01N30/60 ,  B01D15/18 ,  G01N2030/027

Abstract: A column connection method of a liquid chromatograph and a liquid chromatograph capable of keeping a mistakenly installed column by an operator as an unused column are provided. The column connection method of the liquid chromatograph includes: a first step of installing a column at a column installation part and obtaining a first reading result by reading identification information of the column before connecting the column with an analysis flow path; and a second step of connecting the column with the analysis flow path and obtaining a second reading result by reading identification information of the column, in which the first reading result is compared with the second reading result to judge identity of the column.

公开(公告)号：US20240192181A1

公开(公告)日：2024-06-13

申请号：US18286590

申请日：2022-02-02

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Yusuke SHIMIZU ,  Yu IIJIMA ,  Taichiro YAMASHITA ,  Ai MASUDA ,  Daichi FURUKAWA

IPC: G01N30/46 ,  G01N30/60

CPC classification number: G01N30/46 ,  G01N30/6043 ,  G01N30/6091

Abstract: A chromatograph allows easy replacement of a separation column while preventing an operator from contacting with a configuration related to the separation column. A column cartridge accommodates the separation column and is detachably provided in a predetermined column installation position. An upstream pipe is detachably provided on the column cartridge in a state of being installed at the column installation position, and supplies a mobile phase to the separation column of the column cartridge. A downstream pipe is detachably provided on the column cartridge in a state of being installed at the column installation position, and delivers the mobile phase that has passed through the separation column of the column cartridge. A cover integrally covers the column installation position, the upstream pipe, and the downstream pipe and has an insertion hole that allows the column cartridge to be installed from the outer side of the cover.

公开(公告)号：US20240060941A1

公开(公告)日：2024-02-22

申请号：US18265787

申请日：2021-11-26

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Taichiro YAMASHITA ,  Shoji TOMIDA ,  Yusuke SHIMIZU ,  Yu IIJIMA ,  Ai MASUDA ,  Daichi FURUKAWA

IPC: G01N30/60

CPC classification number: G01N30/6047 ,  G01N30/606 ,  G01N30/6091 ,  G01N30/54

Abstract: A technique for replacing a separation column includes: a driving device supporting a first pipe along a first direction; a fixing member that fixes a second pipe to be opposed to the first pipe along the first direction; a column case between the first pipe and the second pipe, having a first and second holes communicating with the first and second pipes, respectively; and an interlocking mechanism that moves the column case in the first direction in conjunction with movement of the first pipe. The column case allows a column cartridge retaining a separation column to be connected and disconnected. The driving device moves the first pipe and the interlocking mechanism such that two states are reversibly taken; a closed state in which the separation column is between the first and second pipes and an open state in which the first and second pipes are positioned outside the column case.

公开(公告)号：US20220155266A1

公开(公告)日：2022-05-19

申请号：US17433119

申请日：2020-02-27

Applicant: Hitachi High-Tech Corporation

Inventor： Makoto NOGAMI ,  Yusuke SHIMIZU ,  Daisuke AKIEDA ,  Kenichiro NISHIKI

IPC: G01N30/54 ,  G01N30/60

Abstract: Implemented is an analysis apparatus column oven equipped with a plurality of columns, which is capable of efficiently performing heat conduction on column basis, recognizing a column cartridge that holds a column, and being easily exchanged on column basis. The column change mechanism 105 includes the ferrule 206, the movable ferrule connector 207, the pipe 208, the fastener pull 209, the fastener fitting 210, the column cartridge presser 211, the slide guide 212, the RFID reader 214, the fixed wall 215, the column changer heat insulating member 216, the fixed bottom plate 217, the receiver 218, and the fixed fitting 219. A plurality of column cartridges 104 can be installed in the heat block 101, and are in contact with the column heat block 103 to control the temperature in the column cartridges 104. The column cartridge 104 is fixed between left and right column change mechanisms 105, and when the fixed column cartridge 104 is opened, the column change mechanism 105 on the left side is moved leftward and opened.

公开(公告)号：US20200249223A1

公开(公告)日：2020-08-06

申请号：US16856459

申请日：2020-04-23

Applicant: Hitachi High-Tech Corporation

Inventor： Ryosuke TAKAHASHI ,  Katsuhiro KANDA ,  Yusuke SHIMIZU ,  Hisashi ICHIKAWA

IPC: G01N33/50 ,  G01N35/10 ,  B01L7/00 ,  G01N33/15 ,  C12M1/12 ,  C12M1/00 ,  C12M1/34

Abstract: Application of the present invention enables quantification of fractions of candidate pharmaceutical compounds (a parent compound and its metabolites), one excreted to the basolateral (Basal/Basolateral)-side via transporters and by diffusion, one excreted to the lumen (Apical)-side, and one remained in the cells. This enables determination of the total amount of the administered candidate pharmaceutical compounds and the distribution ratio of the fractions. The kinetics of the administered candidate pharmaceutical compounds can be evaluated, thereby enabling in vitro screening of an enormous number of candidate pharmaceutical compounds for drug candidates exhibiting the efficacy. The object of the present invention is to provide an apparatus and method for understanding a total picture of pharmacokinetics in vitro by quantifying a fraction of basolateral (Basal/Basolateral) efflux, a fraction of lumen (Apical)-side excretion, and a fraction remaining in a cell of a drug which has been administered to the cell to determine the distribution ratio of each fraction.