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公开(公告)号：GB2583864B
公开(公告)日：2022-07-13
申请号：GB202011413
申请日：2019-01-14
Applicant: IBM
Inventor： JOSHUA THOMAS SMITH , KEVIN WINSTEL , WILLIAM FRANCIS LANDERS , TERESA JACQUELINE WU
IPC: H01L21/768 , B01D15/34 , G01N30/60
Abstract: Microfluidic chips that can comprise thin substrates and/or a high density of vias are described herein. An apparatus comprises: a silicon device layer comprising a plurality of vias, the plurality of vias comprising greater than or equal to about 100 vias per square centimeter of a surface of the silicon device layer and less than or equal to about 100,000 vias per square centimeter of the surface of the silicon device layer, and the plurality of vias extending through the silicon device layer; and a sealing layer bonded to the silicon device layer, wherein the sealing layer has greater rigidity than the silicon device layer. In some embodiments, the silicon device layer has a thickness between about 7 micrometers and about 500 micrometers while a via of the plurality of vias has a diameter between about 5 micrometers and about 5 millimeters.
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公开(公告)号：GB2573932A
公开(公告)日：2019-11-20
申请号：GB201911665
申请日：2018-01-24
Applicant: IBM
Inventor： BENJAMIN HARDY WUNSCH , JOSHUA THOMAS SMITH , HUAN HU , MICHAEL ALBERT PEREIRA
Abstract: A technique relates to a machine for sorting. A removable cartridge (100) includes a nanofluidic module (300). The removable cartridge (100) includes an input port (102) and at least two output ports (112,114). The nanofluidic module (300) is configured to sort a sample fluid (404). A holder (400) is configured to receive the removable cartridge (100). A pressurization system (820) is configured to couple to the input port (102) of the removable cartridge (100). The pressurization system (820) is configured to drive the sample fluid (404) into the nanofluidic module (300) for separation to the at least two output ports (112,114).
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公开(公告)号：GB2548723A
公开(公告)日：2017-09-27
申请号：GB201706188
申请日：2015-11-17
Applicant: IBM
Inventor： JOSHUA THOMAS SMITH , ROBERT LAWSON BRUCE , YANN ANDRE ASTIER , CHAO WANG , BENJAMIN HARDY WUNSCH
Abstract: A technique related to sorting entities is provided. An inlet is configured to receive a fluid, and an outlet is configured to exit the fluid. A nanopillar array, connected to the inlet and the outlet, is configured to allow the fluid to flow from the inlet to the outlet. The nanopillar array includes nanopillars arranged to separate entities by size. The nanopillars are arranged to have a gap separating one nanopillar from another nanopillar. The gap is constructed to be in a nanoscale range.
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公开(公告)号：GB2549627B
公开(公告)日：2021-10-13
申请号：GB201708235
申请日：2015-11-23
Applicant: IBM
Inventor： YANN ANDRE ASTIER , GUSTAVO ALEJANDRO STOLOVITZKY , JOSHUA THOMAS SMITH , CHAO WANG , BENJAMIN HARDY WUNSCH
Abstract: A technique relates sorting entities. The entities are introduced into a nanopillar array. The entities include a first population and a second population, and the nanopillar array includes nanopillars arranged to have a gap separating one from another. The nanopillars are ordered to have an array angle relative to a fluid flow direction. The entities are sorted through the nanopillar array by transporting the first population of the entities less than a predetermined size in a first direction and by transporting the second population of the entities at least the predetermined size in a second direction different from the first direction. The nanopillar array is configured to employ the gap with a gap size less than 300 nanometers in order to sort the entities having a sub-100 nanometer size.
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公开(公告)号：GB2583625A
公开(公告)日：2020-11-04
申请号：GB202010486
申请日：2019-01-14
Applicant: IBM
Inventor： JOSHUA THOMAS SMITH , STACEY GIFFORD , SUNG-CHEOL KIM , BENJAMIN HARDY WUNSCH
IPC: C12M1/00
Abstract: Microfluid chips that comprise one or more microscale and/or mesoscale condenser arrays, which can facilitate particle purification and/or fractionation, are described herein. In one embodiment, an apparatus can comprise a layer of a microfluidic chip. The layer can comprise an inlet that can receive fluid,an outlet that can output a purified version of the fluid, and a condenser array coupled between and in fluid communication with the inlet and the outlet. The condenser array can comprise a plurality of pillars arranged in a plurality of columns. Also, a pillar gap sized to facilitate a throughput rate of the fluid of greater than or equal to about 1.0 nanoliter per hour can be located between a first pillar of the plurality of pillars in a first column of the plurality of columns and a second pillar of the plurality of pillars in the first column.
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Patent Agency Ranking
公开(公告)号：GB2583864A
公开(公告)日：2020-11-11
申请号：GB202011413
申请日：2019-01-14
Applicant: IBM
Inventor： JOSHUA THOMAS SMITH , KEVIN WINSTEL , WILLIAM FRANCIS LANDERS , TERESA JACQUELINE WU
IPC: H01L21/768
Abstract: Microfluidic chips that can comprise thin substrates and/or a high density of vias are described herein. An apparatus comprises: a silicon device layer comprising a plurality of vias, the plurality of vias comprising greater than or equal to about 100 vias per square centimeter of a surface of the silicon device layer and less than or equal to about 100,000 vias per square centimeter of the surface of the silicon device layer, and the plurality of vias extending through the silicon device layer; and a sealing layer bonded to the silicon device layer, wherein the sealing layer has greater rigidity than the silicon device layer. In some embodiments, the silicon device layer has a thickness between about 7 micrometers and about 500 micrometers while a via of the plurality of vias has a diameter between about 5 micrometers and about 5 millimeters.
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公开(公告)号：GB2549627A
公开(公告)日：2017-10-25
申请号：GB201708235
申请日：2015-11-23
Applicant: IBM
Inventor： YANN ANDRE ASTIER , GUSTAVO ALEJANDRO STOLOVITZKY , JOSHUA THOMAS SMITH , CHAO WANG , BENJAMIN HARDY WUNSCH
Abstract: A technique relates sorting entities. The entities are introduced into a nanopillar array. The entities include a first population and a second population, and the nanopillar array includes nanopillars arranged to have a gap separating one from another. The nanopillars are ordered to have an array angle relative to a fluid flow direction. The entities aresorted through the nanopillar array by transporting the first population of the entities less than a predetermined size in a first direction and by transporting the second population of the entities at least the predetermined size in a second direction different from the first direction. The nanopillar array is configured to employ the gap with a gap size less than 300 nanometers in order to sort the entities having a sub-100 nanometer size.
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公开(公告)号：GB2583301B
公开(公告)日：2022-11-16
申请号：GB202010161
申请日：2019-01-14
Applicant: IBM
Inventor： BENJAMIN HARDY WUNSCH , JOSHUA THOMAS SMITH , SUNG-CHEOL KIM , STACEY GIFFORD
IPC: H01L23/427
Abstract: Microscale and/or mesoscale condenser arrays that can facilitate microfluidic separation and/or purification of mesoscale and/or nanoscale particles and methods of operation are described herein. An apparatus comprises a condenser array comprising pillars arranged in a plurality of columns, wherein a pillar gap greater than or equal to about 0.5 micrometers is located between a first pillar of the pillars in a first column of the columns and a second pillar of the plurality of pillars in the first column, and wherein the first pillar is adjacent to the second pillar. The first ratio can be characterized by Dx/Dy is less than or equal to a first defined value, wherein Dx represents a first distance across the lattice in a first direction, wherein Dy represents a second distance across the lattice in a second direction, and wherein the first direction is orthogonal to the second direction.
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公开(公告)号：GB2573932B
公开(公告)日：2022-06-15
申请号：GB201911665
申请日：2018-01-24
Applicant: IBM
Inventor： BENJAMIN HARDY WUNSCH , JOSHUA THOMAS SMITH , HUAN HU , MICHAEL ALBERT PEREIRA
Abstract: A technique relates to a machine for sorting. A removable cartridge includes a nanofluidic module. The removable cartridge includes an input port and at least two output ports. The nanofluidic module is configured to sort particles in a sample fluid. A holder is configured to receive the removable cartridge. A pressurization system is configured to couple to the input port of the removable cartridge. The pressurization system is configured to drive the sample fluid into the nanofluidic module for separation to the at least two output ports.
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公开(公告)号：GB2583301A
公开(公告)日：2020-10-21
申请号：GB202010161
申请日：2019-01-14
Applicant: IBM
Inventor： BENJAMIN HARDY WUNSCH , JOSHUA THOMAS SMITH , SUNG-CHEOL KIM , STACEY GIFFORD
IPC: H01L23/427
Abstract: Microscale and/or mesoscale condenser arrays that can facilitate microfluidic separation and/or purification of mesoscale and/or nanoscale particles and methods of operation are described herein. An apparatus comprises a condenser array comprising pillars arranged in a plurality of columns, wherein a pillar gap greater than or equal to about 0.5 micrometers is located between a first pillar of the pillars in a first column of the columns and a second pillar of the plurality of pillars in the first column, and wherein the first pillar is adjacent to the second pillar. The first ratio can be characterized by Dx /Dy is less than or equal to a first defined value, wherein Dx represents a first distance across the lattice in a first direction, wherein Dy represents a second distance across the lattice in a second direction, and wherein the first direction is orthogonal to the second direction.
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