公开(公告)号：JP2004193614A

公开(公告)日：2004-07-08

申请号：JP2003409522

申请日：2003-12-08

Applicant: Internatl Business Mach Corp ,  インターナショナル・ビジネス・マシーンズ・コーポレーションInternational Business Maschines Corporation

Inventor： CHUDZIK MICHAEL PATRICK ,  DENNARD ROBERT H ,  DIVAKARUNI RAMA ,  FURMAN BRUCE KENNETH ,  JAMMY RAJARAO ,  NARAYAN CHANDRASEKHAR ,  PURUSHOTHAMAN SAMPATH ,  SHEPARD JR JOSEPH F ,  TOPOL ANNA WANDA

IPC: H01L23/12 ,  H01L23/50 ,  H01L25/04 ,  H01L25/18 ,  H01L29/40 ,  H05K1/16 ,  H05K3/46

CPC classification number: H05K1/162 ,  H01L23/147 ,  H01L23/481 ,  H01L23/49827 ,  H01L23/50 ,  H01L2224/16225 ,  H01L2924/01019 ,  H01L2924/01055 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/15311 ,  H01L2924/157 ,  H01L2924/30105 ,  H05K1/167 ,  H05K3/4602 ,  H05K2201/09809

Abstract: PROBLEM TO BE SOLVED: To provide a structure for an integrated carrier equipped with high frequency and high speed passive components for computing. SOLUTION: A carrier 200 for a semiconductor component 102 is provided, which has passive components 3010 integrated in its substrate. The passive components 3010 include decoupling components, such as capacitors and resistors. A set of connections 210 is integrated in a close electrical proximity to the supported components. COPYRIGHT: (C)2004,JPO&NCIPI

公开(公告)号：CA3081233A1

公开(公告)日：2012-06-21

申请号：CA3081233

申请日：2011-11-21

Applicant: IBM

Inventor： BODAY DYLAN ,  SCHWARTZ STEPHEN LEONARD ,  TOPOL ANNA WANDA ,  WATERS SANDRA LYNN ,  WINARSKI DANIEL JAMES

IPC: G01N33/543 ,  G01N33/551 ,  G01N33/553

Abstract: Described are embodiments of an invention for detecting target antigens in a biological sample using a sample assembly. Detection may be accomplished by performing a method comprising: sweeping a head module over the sample assembly, wherein said head module includes at least one magneto-resistive read sensor configured to detect target antigens via nanoparticles within the sample assembly; and detecting at least one particular antigen among the target antigens. Preferably, detecting the target antigens via the nanoparticles is based at least in part on detecting unique magnetic properties of particular nanoparticles specifically associated with different types of the target antigens. Detection using a magnetic read/write head in the sample assembly facilitates automation of sample detection with high speed and fidelity. Corresponding systems are also disclosed.

公开(公告)号：CA2817125C

公开(公告)日：2020-08-04

申请号：CA2817125

申请日：2011-11-21

Applicant: IBM

Inventor： WINARSKI DANIEL JAMES ,  TOPOL ANNA WANDA ,  WATERS SANDRA LYNN ,  SCHWARTZ STEPHEN LEONARD ,  BODAY DYLAN

IPC: G01N33/543 ,  G01N33/553

Abstract: A method of forming a sample assembly of a biological sample having target antigens comprises: forming at least one sample trench within an outer layer, the sample trench having a bottom surface; forming a base layer; bonding a first set of antibodies within the sample trench on a first surface of the base layer; exposing the sample trench with the first set of bonded antibodies to the biological sample having target antigens, the target antigens bonding with the first set of antibodies within the sample trench; bonding a second set of antibodies to nanoparticles, the first and second sets of antibodies being biologically identical; and exposing the target antigens within the sample trench to the second set of antibodies bonded to the nanoparticles, the second set of antibodies bonding with the target antigens within the sample trench.

公开(公告)号：CA2817125A1

公开(公告)日：2012-06-21

申请号：CA2817125

申请日：2011-11-21

Applicant: IBM

Inventor： WINARSKI DANIEL JAMES ,  TOPOL ANNA WANDA ,  WATERS SANDRA LYNN ,  SCHWARTZ STEPHEN LEONARD ,  BODAY DYLAN

IPC: G01N33/543

Abstract: A method of forming a sample assembly of a biological sample having target antigens comprises: forming at least one sample trench within an outer layer, the sample trench having a bottom surface; forming a base layer; bonding a first set of antibodies within the sample trench on a first surface of the base layer; exposing the sample trench with the first set of bonded antibodies to the biological sample having target antigens, the target antigens bonding with the first set of antibodies within the sample trench; bonding a second set of antibodies to nanoparticles, the first and second sets of antibodies being biologically identical; and exposing the target antigens within the sample trench to the second set of antibodies bonded to the nanoparticles, the second set of antibodies bonding with the target antigens within the sample trench.

公开(公告)号：DE112011104401T5

公开(公告)日：2013-09-19

申请号：DE112011104401

申请日：2011-11-21

Applicant: IBM

Inventor： SCHWARTZ STEPHEN LEONARD ,  WINARSKI DANIEL JAMES ,  TOPOL ANNA WANDA ,  WATERS SANDRA LYNN ,  BODAY DYLAN

IPC: G01N33/543

Abstract: Ein Verfahren zum Bilden einer Probenanordnung einer biologischen Probe, die Zielantigene aufweist, wobei das Verfahren aufweist: Bilden von mindestens einer Probenrinne innerhalb einer äußeren Schicht, wobei die Probenrinne eine untere Oberfläche aufweist; Bilden einer Grundschicht; Binden eines ersten Satzes von Antikörpern innerhalb der mindestens einen Probenrinne an eine erste Oberfläche der Grundschicht; Exponieren der Probenrinne mit dem ersten Satz gebundener Antikörper gegenüber der biologischen Probe, welche die Zielantigene aufweist, wobei sich die Zielantigene an die erste Gruppe von Antikörpern innerhalb der Probenrinne binden; Binden eines zweiten Satzes von Antikörpern an Nanopartikel, wobei der erste und zweite Satz von Antikörpern biologisch identisch sind; und Exponieren der Zielantigene innerhalb der Probenrinne gegenüber dem zweiten Satz von an die Nanopartikel gebundenen Antikörpern, wobei sich der zweite Satz von Antikörpern an die Zielantigene innerhalb der Probenrinne binden.

公开(公告)号：CA3081236A1

公开(公告)日：2012-06-21

申请号：CA3081236

申请日：2011-11-21

Applicant: IBM

Inventor： BODAY DYLAN ,  SCHWARTZ STEPHEN LEONARD ,  TOPOL ANNA WANDA ,  WATERS SANDRA LYNN ,  WINARSKI DANIEL JAMES

Abstract: Described are embodiments of an invention for detecting target antigens in a biological sample using a sample assembly. Detection may be accomplished by performing a method comprising: sweeping a head module over the sample assembly, wherein said head module includes at least one magneto-resistive read sensor configured to detect target antigens via nanoparticles within the sample assembly; and detecting at least one particular antigen among the target antigens. Preferably, detecting the target antigens via the nanoparticles is based at least in part on detecting unique magnetic properties of particular nanoparticles specifically associated with different types of the target antigens. Detection using a magnetic read/write head in the sample assembly facilitates automation of sample detection with high speed and fidelity. Corresponding systems are also disclosed.

公开(公告)号：DE112011104401B4

公开(公告)日：2016-01-14

申请号：DE112011104401

申请日：2011-11-21

Applicant: IBM

Inventor： SCHWARTZ STEPHEN LEONARD ,  WINARSKI DANIEL JAMES ,  TOPOL ANNA WANDA ,  WATERS SANDRA LYNN ,  BODAY DYLAN

IPC: G01N33/543

Abstract: Verfahren zum Bilden einer Probenanordnung einer biologischen Probe, die Zielantigene aufweist, wobei das Verfahren aufweist: Bilden von mindestens einer Probenrinne innerhalb einer äußeren Schicht, wobei die Probenrinne eine untere Oberfläche aufweist; Bilden einer Grundschicht; Binden eines ersten Satzes von Antikörpern innerhalb der mindestens einen Probenrinne auf einer ersten Oberfläche der Grundschicht; die mindestens eine Probenrinne mit dem ersten Satz gebundener Antikörper der biologischen Probe aussetzen, welche die Zielantigene aufweist, wobei sich die Zielantigene an den ersten Satz von Antikörpern innerhalb der mindestens einen Probenrinne binden; Binden eines zweiten Satzes von Antikörpern an Nanopartikel, wobei der erste und zweite Satz von Antikörpern biologisch identisch sind; die Zielantigene innerhalb der mindestens einen Probenrinne dem zweiten Satz von an die Nanopartikel gebundenen Antikörpern aussetzen, wobei sich die zweite Gruppe von Antikörpern an die Zielantigene innerhalb der mindestens einen Probenrinne binden; und Bilden einer Mehrzahl magnetischer Servoausrichtungsmarkierungen auf der Probenanordnung.

公开(公告)号：GB2500548A

公开(公告)日：2013-09-25

申请号：GB201312478

申请日：2011-11-21

Applicant: IBM

Inventor： TOPOL ANNA WANDA ,  WATERS SANDRA LYNN ,  SCHWARTZ STEPHEN LEONARD ,  BODAY DYLAN JOSEPH ,  WINARSKI DANIEL JAMES

IPC: G01N33/543

Abstract: A method of forming a sample assembly of a biological sample having target antigens comprises: forming at least one sample trench within an outer layer, the sample trench having a bottom surface; forming a base layer; bonding a first set of antibodies within the sample trench on a first surface of the base layer; exposing the sample trench with the first set of bonded antibodies to the biological sample having target antigens, the target antigens bonding with the first set of antibodies within the sample trench; bonding a second set of antibodies to nanoparticles, the first and second sets of antibodies being biologically identical; and exposing the target antigens within the sample trench to the second set of antibodies bonded to the nanoparticles, the second set of antibodies bonding with the target antigens within the sample trench.