-
公开(公告)号：JP2000002707A
公开(公告)日：2000-01-07
申请号：JP13582899
申请日：1999-05-17
Applicant: IDEXX LAB INC
Inventor： GROAT RANDALL G , O'CONNOR THOMAS P , MERMER BRION
IPC: C07K7/08 , C07K14/155 , G01N33/569
Abstract: PROBLEM TO BE SOLVED: To provide a method and an apparatus for diagnosing the presence of a feline immune deficiency. SOLUTION: In this method for deciding whether a feline is infected by a feline immunodeficiency virus(FIV), a biological sample of the feline is given, the sample is brought into contact with an antibody binding capture composition containing (i) a first enhanced capture polypeptide containing an immunogeneic fragment of an FIVgag precursor p55 and (ii) a second enhanced capture polypeptide containing an immunogeneic fragment of an FIVenv precursor gp130, and the reaction of the antibody in the sample is detected by using the capture composition. Here, the generation of the reaction represents that the feline is infected with the FIV.
-
公开(公告)号：WO0058365A9
公开(公告)日：2001-11-15
申请号：PCT/US0008347
申请日：2000-03-30
Applicant: IDEXX LAB INC , LAWTON ROBERT , MERMER BRION , FRANCOEUR GREG
Inventor： LAWTON ROBERT , MERMER BRION , FRANCOEUR GREG
CPC classification number: C07K16/4291
Abstract: Disclosed are binding proteins that specifically bind to an isolated and purified peptide comprising a leucine positioned two peptide bonds away from a tyrosine-arginine pair. Other binding proteins of the invention include those that specifically bind to an isolated and purified peptide with the sequence cysteine-blank-blank-proline-histidine-blank-blank-blank-cysteine (SEQ ID NO:6) or cysteine-blank-proline-histidine-blank-proline-blank-blank-cysteine (SEQ ID NO:9).
Abstract translation: 公开了特异性结合分离和纯化的肽的结合蛋白，其包含位于离开酪氨酸 - 精氨酸对的两个肽键的亮氨酸。 本发明的其它结合蛋白包括与序列半胱氨酸 - 空白 - 空白 - 脯氨酸 - 组氨酸 - 空白 - 空白 - 半胱氨酸（SEQ ID NO：6）或半胱氨酸 - 空白 - 脯氨酸特异性结合分离和纯化的肽的那些 - 组氨酸 - 空白 - 脯氨酸 - 空白 - 空白 - 半胱氨酸（SEQ ID NO：9）。
-
公开(公告)号：WO0111049A2
公开(公告)日：2001-02-15
申请号：PCT/US0021651
申请日：2000-08-09
Applicant: IDEXX LAB INC , GUO HONGLIANG , LAWTON ROBERT , MERMER BRION , AIYAPPA ASHOK P
Inventor： GUO HONGLIANG , LAWTON ROBERT , MERMER BRION , AIYAPPA ASHOK P
IPC: A61K38/00 , A61K39/00 , C07K14/54 , C07K16/24 , C12N15/24 , A61K38/20 , A61K39/395 , C12N5/10 , C12N15/11 , G01N33/68
CPC classification number: C07K16/244 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/5409
Abstract: The present invention provides for the isolation and characterization of canine interleukin-5 (IL-5) and nucleic acid and amino acid sequences of IL-5. More particularly, recombinant DNA molecules encoding for canine interleukin-5 and conservative variants are provided. In other aspects, the invention provides cells comprising the recombinant vectors, and methods for producing canine IL-5 comprising the steps of inserting a transcription regulatory sequence proximal to the IL-5 gene in a cell comprising that gene, and stimulating production of IL-5 through the regulatory sequence.
Abstract translation: 本发明提供了白介素-5（IL-5）和IL-5的核酸和氨基酸序列的分离和表征。 更具体地，提供了编码犬白介素-5和保守变体的重组DNA分子。 在其他方面，本发明提供了包含重组载体的细胞，以及用于产生犬IL-5的方法，其包括以下步骤：将包含该基因的细胞中的IL-5基因的接近的转录调节序列插入，并刺激IL- 5通过调节序列。
-
4.发明申请NUCLEOTIDES AND PEPTIDES CORRESPONDING TO THE CANINE IGE HEAVY CHAIN CONSTANT REGION AND RELATED METHODS 审中-公开与犬类重力链恒定区相关的核苷酸和相关方法
公开(公告)号：WO9730156A3
公开(公告)日：1997-10-09
申请号：PCT/US9702322
申请日：1997-02-14
Applicant: IDEXX LAB INC
Inventor： MERMER BRION , HARRIS RACHEL A , SIEFRING ANN E
IPC: A61K38/00 , C07K16/00 , C12N15/13 , A61K39/395 , C07K1/21 , C07K1/42 , C07K16/85 , C12N5/10 , C12N15/11
CPC classification number: C07K16/00 , A61K38/00 , C07K2319/02
Abstract: Recombinant DNA molecules encoding complete canine IgE heavy chain constant region and the DNA sequence for all six exons of canine IgE are disclosed. The canine IgE heavy chain constant region DNA sequence was isolated using a nested walking procedure that is also disclosed. Also disclosed are peptides encoded by said sequences, including recombinant canine IgE heavy chain peptides produced by prokaryotic or eukaryotic cells. Such peptides are used in methods to treat the manifestation of allergy in dogs. Disclosed are antibodies that bind to peptides disclosed herein, as well as such antibodies for use to treat the manifestations of allergy in dogs.
-
公开(公告)号：AU4044900A
公开(公告)日：2000-10-16
申请号：AU4044900
申请日：2000-03-30
Applicant: IDEXX LAB INC
Inventor： LAWTON ROBERT , MERMER BRION , FRANCOEUR GREG
-
Patent Agency Ranking
公开(公告)号：CA2271449C
公开(公告)日：2010-07-13
申请号：CA2271449
申请日：1999-05-14
Applicant: IDEXX LAB INC
Inventor： GROAT RANDALL G , O'CONNOR THOMAS P , MERMER BRION
IPC: C12Q1/70 , C07K7/08 , C07K14/155 , G01N33/569 , G01N33/577
Abstract: Methods for determining whether a feline is infected with feline immunodeficiency virus ("FIV"). The methods involve the use of an antibody-binding composition that includes two enhanced polypeptides, one containing an immunogenic fragment of the FIV gag precursor p55 and the other containing an immunogenic fragment of the FIV env precursor gp130. Also featured a.re devices for practicing these methods.
-
公开(公告)号：DE60127237T2
公开(公告)日：2007-12-20
申请号：DE60127237
申请日：2001-01-30
Applicant: IDEXX LAB INC
Inventor： LAWTON ROBERT L , AIYAPPA ASHOK P , LIU WENDY W , MERMER BRION , GUO HONGLIANG , KRAH EUGENE R
Abstract: The present invention provides methods and compositions for decreasing IgE levels in dogs. The methods and compositions are useful for treating allergic symptoms in dogs. The invention may comprise chimeric canine anti-IgE monoclonal antibody compositions and methods for using the compositions in the treatment of allergy. In preferred embodiments, the compositions of the present invention may act by binding soluble IgE in plasma, or by inhibiting IgE from binding to receptors on mast cells, B cells, and basophils.
-
公开(公告)号：ES2200472T3
公开(公告)日：2004-03-01
申请号：ES99303760
申请日：1999-05-14
Applicant: IDEXX LAB INC
Inventor： GROAT RANDALL G , MERMER BRION , O'CONNOR THOMAS P
IPC: C07K7/08 , C07K14/155 , G01N33/569
Abstract: We disclose methods for determining whether a feline is infected with feline immunodeficiency virus ("FIV"). The methods involve the use of an antibody-binding composition that includes two enhanced polypeptides, one containing an immunogenic fragment of the FIV gag precursor p55 and the other containing an immunogenic fragment of the FIV env precursor gp130. Also disclosed are devices for practising these methods.
-
公开(公告)号：AT246359T
公开(公告)日：2003-08-15
申请号：AT99303760
申请日：1999-05-14
Applicant: IDEXX LAB INC
Inventor： GROAT RANDALL G , MERMER BRION , O'CONNOR THOMAS P
IPC: C07K7/08 , C07K14/155 , G01N33/569
Abstract: We disclose methods for determining whether a feline is infected with feline immunodeficiency virus ("FIV"). The methods involve the use of an antibody-binding composition that includes two enhanced polypeptides, one containing an immunogenic fragment of the FIV gag precursor p55 and the other containing an immunogenic fragment of the FIV env precursor gp130. Also disclosed are devices for practising these methods.
-
公开(公告)号：ES2234180T3
公开(公告)日：2005-06-16
申请号：ES99107035
申请日：1999-04-09
Applicant: IDEXX LAB INC
Inventor： LAWTON ROBERT , MERMER BRION , FRANCOEUR GREG
Abstract: LA INVENCION SE REFIERE A PROTEINAS DE UNION QUE SE UNEN ESPECIFICAMENTE A UN PEPTIDO AISLADO Y PURIFICADO QUE COMPRENDE UNA LEUCINA SITUADA A UNA DISTANCIA DE DOS ENLACES PEPTIDICO DE UN PAR TIROSINA - ARGININA. OTRAS PROTEINAS DE UNION DE LA INVENCION INCLUYEN AQUELLAS QUE SE UNEN ESPECIFICAMENTE A UN PEPTIDO AISLADO Y PURIFICADO CON LA SECUENCIA CISTEINA - HUECO HUECO - PROLINA - HISTIDINA - HUECO - HUECO - HUECO - CISTEINA, O CISTEINA - HUECO - PROLINA - HISTIDINA - HUECO - PROLINA HUECO - HUECO - CISTEINA.
-
-
-
-
-
-
-
-
-
Search Results
26
records
(took 0.024 seconds)
