公开(公告)号：EP2715353A4

公开(公告)日：2014-12-17

申请号：EP12792727

申请日：2012-05-31

Applicant: IDEXX LAB INC

Inventor： YERRAMILLI MURTHY V S N ,  YERRAMILLI MAHALAKSHMI ,  ATKINSON MICHAEL

IPC: G01N33/74

CPC classification number: G01N33/54306 ,  G01N33/74 ,  G01N2333/58 ,  G01N2800/32

公开(公告)号：EP3041576A4

公开(公告)日：2017-07-26

申请号：EP14842603

申请日：2014-09-05

Applicant: IDEXX LAB INC

Inventor： YERRAMILLI MAHALAKSHMI ,  YERRAMILLI MURTHY V S N

IPC: G01N33/68 ,  G01N33/70

CPC classification number: G01N33/6812 ,  G01N33/70 ,  G01N2800/347 ,  G01N2800/52 ,  Y02A90/24

Abstract: The disclosure is directed to methods and apparatus for the determination, diagnosis, progression and prognosis of kidney disease and mortality associated with kidney disease. The disclosure includes methods for determining renal function, in particular estimating glomerular filtration rate (GFR), in an animal. GFR can be useful in the diagnosis and treatment of kidney disease or dysfunction. In various aspects, the disclosure is directed to the use of free symmetrical dimethylarginine (SDMA) and creatinine in blood samples from animals, in particular cats and dogs, to determine glomerular filtration rate and kidney disease.

Abstract translation: 本公开涉及用于确定，诊断，进展和预后与肾病相关的肾病和死亡率的方法和装置。 本公开包括用于确定动物中的肾功能，特别是估计肾小球滤过率（GFR）的方法。 GFR可用于诊断和治疗肾脏疾病或功能障碍。 在各个方面，本公开涉及在来自动物，特别是猫和狗的血液样品中使用游离对称二甲基精氨酸（SDMA）和肌酸酐，以确定肾小球滤过率和肾病。

公开(公告)号：NZ717554A

公开(公告)日：2022-04-29

申请号：NZ71755414

申请日：2014-09-05

Applicant: IDEXX LAB INC

Inventor： YERRAMILLI MAHALAKSHMI ,  YERRAMILLI MURTHY

IPC: A61P13/12

Abstract: The disclosure is directed to methods and apparatus for the determination, diagnosis, progression and prognosis of kidney disease and mortality associated with kidney disease. The disclosure includes a method for determining renal function, in particular estimating glomerular filtration rate (GFR), in an animal. GFR can be useful in the diagnosis and treatment of kidney disease or dysfunction. In various aspects, the disclosure is directed to the use of free symmetrical dimethylarginine (SDMA) and creatinine in blood samples from animals, in particular cats and dogs, to determine glomerular filtration rate and kidney disease.

公开(公告)号：AU2017204499B2

公开(公告)日：2019-05-16

申请号：AU2017204499

申请日：2017-06-30

Applicant: IDEXX LAB INC

Inventor： YERRAMILLI MAHALAKSHMI ,  ATKINSON MICHAEL RANDOLPH ,  YERRAMILLI MURTHY V S N

IPC: G01N33/68 ,  C07K14/00 ,  C07K14/775 ,  G01N33/53

Abstract: MARKERS FOR RENAL DISEASE This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, 5 or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.

公开(公告)号：AU2015230872B2

公开(公告)日：2017-05-11

申请号：AU2015230872

申请日：2015-09-29

Applicant: IDEXX LAB INC

Inventor： YERRAMILLI MAHALAKSHMI ,  ATKINSON MICHAEL RANDOLPH ,  YERRAMILLI MURTHY V S N

IPC: G01N33/68 ,  C07K14/00 ,  C07K14/775 ,  G01N33/53

Abstract: MARKERS FOR RENAL DISEASE This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, 5 or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.

公开(公告)号：AU2020256440A1

公开(公告)日：2020-11-12

申请号：AU2020256440

申请日：2020-10-16

Applicant: IDEXX LAB INC

Inventor： YERRAMILLI MAHALAKSHMI ,  YERRAMILLI MURTHY V S N

IPC: G01N33/70 ,  A61P13/12

Abstract: The disclosure is directed to methods and apparatus for the determination, diagnosis, progression and prognosis of kidney disease and mortality associated with kidney disease. The disclosure includes a method for determining renal function, in particular estimating glomerular filtration rate (GFR), in an animal. GFR can be useful in the diagnosis and treatment of kidney disease or dysfunction. In various aspects, the disclosure is directed to the use of free symmetrical dimethylarginine (SDMA) and creatinine in blood samples from animals, in particular cats and dogs, to determine glomerular filtration rate and kidney disease.

公开(公告)号：ES2746008T3

公开(公告)日：2020-03-04

申请号：ES14842603

申请日：2014-09-05

Applicant: IDEXX LAB INC

Inventor： YERRAMILLI MAHALAKSHMI ,  YERRAMILLI MURTHY

IPC: G01N33/68 ,  G01N33/70

Abstract: Método para estimar la tasa de filtración glomerular (GFR) en un sujeto animal, comprendiendo el método: medir la concentración de dimetilarginina simétrica libre (SDMA) en una muestra de sangre del sujeto; medir la concentración de creatinina en una muestra de sangre del sujeto; y comparar un valor resultante de una ecuación que comprende el producto de la concentración de creatinina y la concentración de SDMA libre con uno o más valores convencionales que se correlacionan con la tasa de filtración glomerular en el sujeto animal.

公开(公告)号：ZA201806418B

公开(公告)日：2019-07-31

申请号：ZA201806418

申请日：2018-09-26

Applicant: IDEXX LAB INC

Inventor： YERRAMILLI MAHALAKSHMI ,  FARACE GIOSI ,  QUINN JOHN JOSEPH ,  YERRAMILLI MURTHY V S N

Abstract: The disclosure provides compositions and methods for the detection of renal disease and periodontal disease in mammals.

公开(公告)号：AU2017204499A1

公开(公告)日：2017-07-20

申请号：AU2017204499

申请日：2017-06-30

Applicant: IDEXX LAB INC

Inventor： YERRAMILLI MAHALAKSHMI ,  ATKINSON MICHAEL RANDOLPH ,  YERRAMILLI MURTHY V S N

IPC: G01N33/68 ,  C07K14/00 ,  C07K14/775 ,  G01N33/53

Abstract: MARKERS FOR RENAL DISEASE This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, 5 or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.

公开(公告)号：AU2011285694A1

公开(公告)日：2013-02-28

申请号：AU2011285694

申请日：2011-08-04

Applicant: IDEXX LAB INC

Inventor： YERRAMILLI MAHALAKSHMI ,  ATKINSON MICHAEL RANDOLPH ,  YERRAMILLI MURTHY V S N

IPC: G01N33/68 ,  G01N33/74

Abstract: A method for determining the amount of NT-proBNP in blood samples from animals. The method includes detecting degradation products of NT-proBNP by various methods, including using antibodies, kits and device.