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    OPTOACOUSTIC IMAGING SYSTEM
    2.
    发明公开
    OPTOACOUSTIC IMAGING SYSTEM 有权
    OPTO声成像系统

    公开(公告)号：EP1077643A1

    公开(公告)日：2001-02-28

    申请号：EP99921767.2

    申请日：1999-05-07

    Applicant: IMARX PHARMACEUTICAL CORP.

    Inventor： UNGER, Evan, C. ,  WU, Yunqiu

    IPC: A61B8/00 ,  G01S15/02 ,  G01N29/00 ,  H04N5/30

    CPC classification number: A61B5/0091 ,  A61B5/0095 ,  A61B5/4312 ,  A61B8/0825 ,  A61B8/0833 ,  A61B8/5238 ,  G01S7/52074 ,  G01S15/8918 ,  G01S15/8922 ,  G01S17/89

    Abstract: An optoacoustic system comprises an optoacoustic transducer (10) including a first array of acoustic transducers (10C, 10D) and a second array of optical fibers (10A, 10B); an acoustic subsystem (18, 20, 30, 34) for controllably exciting at least a first subset of the acoustic transducers to generate acoustic pulses with a prescribed pulse width, and for forming a first image based on return acoustic pulses reflected from a patient; an optical subsystem (14, 20, 22, 24, 26, 30, 32) for controllably generating optical pulses to be transmitted through at least a first subset of the optical fibers toward the patient, and for forming a second image based on light reflected from the patient; and image correlation means (16, 20, 17) for correlating the first and second images. The first and second arrays may take various forms, including the form of an annular array in which the acoustic transducers are arranged coaxially and the optical fibers are disposed around an outer periphery of the first array. The first and second arrays may also take the form of linear arrays.

    NOVEL METHODS OF IMAGING AND TREATMENT WITH TARGETED COMPOSITIONS
    6.
    发明公开
    NOVEL METHODS OF IMAGING AND TREATMENT WITH TARGETED COMPOSITIONS 审中-公开
    方法用于成像和疗法的靶向药物

    公开(公告)号：EP1146911A2

    公开(公告)日：2001-10-24

    申请号：EP00914480.9

    申请日：2000-02-02

    Applicant: IMARX PHARMACEUTICAL CORP.

    Inventor： UNGR, Evan, C. ,  WU, Yunqiu

    IPC: A61K49/00

    CPC classification number: A61K49/225 ,  A61K49/223 ,  A61K49/227 ,  A61K49/228 ,  B82Y5/00

    Abstract: Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The scanning may comprise exposing the patient to a first type of ultrasound energy and then interrogating the patient using a second type of ultrasound energy. The targeting ligand preferably targets tissus, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The methods may be used to detect a thrombus, enhancement of an old or echogenic thrombus low concentrations of vesicles and vesicles targeted to tissues, cells or receptors.

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