公开(公告)号：AU2020409728A1

公开(公告)日：2022-08-11

申请号：AU2020409728

申请日：2020-12-18

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： BARTOLOMÉ-NEBREDA JOSÉ MANUEL ,  BUIJNSTERS PETRUS JACOBUS JOHANNES ANTONIUS ,  DE LUCAS OLIVARES ANA ISABEL ,  LEENAERTS JOSEPH ELISABETH ,  MARTINEZ LAMENCA CAROLINA ,  OEHLRICH DANIEL ,  TRABANCO-SUÁREZ ANDRÉS AVELINO ,  VAN ROOSBROECK YVES EMIEL M ,  VELTER ADRIANA INGRID

IPC: C07D471/04 ,  A61K31/437 ,  A61P25/28

Abstract: The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C9ORF72 mutations.