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公开(公告)号：AU2020409728A1
公开(公告)日：2022-08-11
申请号：AU2020409728
申请日：2020-12-18
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： BARTOLOMÉ-NEBREDA JOSÉ MANUEL , BUIJNSTERS PETRUS JACOBUS JOHANNES ANTONIUS , DE LUCAS OLIVARES ANA ISABEL , LEENAERTS JOSEPH ELISABETH , MARTINEZ LAMENCA CAROLINA , OEHLRICH DANIEL , TRABANCO-SUÁREZ ANDRÉS AVELINO , VAN ROOSBROECK YVES EMIEL M , VELTER ADRIANA INGRID
IPC: C07D471/04 , A61K31/437 , A61P25/28
Abstract: The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C9ORF72 mutations.
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公开(公告)号：MA52939A
公开(公告)日：2021-04-28
申请号：MA52939
申请日：2019-06-20
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： BARTOLOMÉ-NEBREDA JOSÉ MANUEL , BUIJNSTERS PETRUS JACOBUS JOHANNES ANTONIUS , LEENAERTS JOSEPH ELISABETH , MARTINEZ LAMENCA CAROLINA , OEHLRICH DANIEL , TRABANCO-SUÁREZ ANDRÉS AVELINO , VAN ROOSBROECK YVES EMIEL MARIA , VELTER ADRIANA INGRID
IPC: A61K31/437 , A61K31/444 , A61K31/501 , A61P25/28 , C07D471/04
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公开(公告)号：EA039847B1
公开(公告)日：2022-03-18
申请号：EA201991094
申请日：2017-10-31
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： VAN ROOSBROECK YVES EMIEL MARIA , VAN DEN KEYBUS FRANS ALFONS MARIA , VELTER ADRIANA INGRID , BUIJNSTERS PETER JACOBUS JOHANNES ANTONIUS , TRESADERN GARY JOHN , GIJSEN HENRICUS JACOBUS MARIA
Abstract: Изобретениеотноситсяк новымпроизводным [1,2,4]триазоло[1,5-а]пиримидинилаформулы (IA), где RA имеетзначения, определенныев формулеизобретения, вкачествеингибиторовфосфодиэстеразы 2 (PDE2). Настоящееизобретениетакжеотноситсяк фармацевтическимкомпозициям, содержащимсоединения, кспособамполучениятакихкомпозицийи кприменениютакихсоединенийи композицийдлялеченияилипредупреждениярасстройствацентральнойнервнойсистемы, опосредованногофосфодиэстеразой-2.
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公开(公告)号：UA125302C2
公开(公告)日：2022-02-16
申请号：UAA201906027
申请日：2017-10-31
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： VAN ROOSBROECK YVES EMIEL MARIA , VAN DEN KEYBUS FRANS ALFONS MARIA , TRESADERN GARY JOHN , BUIJNSTERS PETER JACOBUS JOHANNES ANTONIUS , VELTER ADRIANA INGRID , JACOBY EDGAR , MACDONALD GREGOR JAMES , GIJSEN HENRICUS JACOBUS MARIA , AHNAOU ABDELLAH , DRINKENBURG WILHELMUS HELENA IGNATIUS MARIA
Abstract: Данийвинахідстосуєтьсянових [1,2,4]триазоло[1,5-a]піримідинільнихпохіднихякінгібіторівфосфодіестерази 2 (PDE2). Данийвинахідтакожспрямованийнафармацевтичнікомпозиції, якімістятьсполуки, наспособиодержаннятакихсполукі композиційтаназастосуваннятакихсполукі композиційдляпопередженняталікуваннярозладів, доякихзалучена PDE2, такихякневрологічнітапсихічнірозлади.
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公开(公告)号：CA2891755C
公开(公告)日：2021-10-26
申请号：CA2891755
申请日：2014-01-16
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： BISCHOFF FRANCOIS PAUL , VELTER ADRIANA INGRID , ROMBOUTS FREDERIK JAN RITA , DE CLEYN MICHEL ANNA JOZEF , VAN BRANDT SVEN FRANCISCUS ANNA , GIJSEN HENRICUS JACOBUS MARIA , ZAVATTARO CHIARA , VAN DEN KEYBUS FRANS ALFONS MARIA
IPC: C07D471/04 , A61K31/498 , A61P25/28
Abstract: The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I). The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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Patent Agency Ranking
公开(公告)号：AU2017353313B2
公开(公告)日：2021-09-16
申请号：AU2017353313
申请日：2017-10-31
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： VAN ROOSBROECK YVES EMIEL MARIA , VAN DEN KEYBUS FRANS ALFONS MARIA , VELTER ADRIANA INGRID , BUIJNSTERS PETER JACOBUS JOHANNES ANTONIUS , TRESADERN GARY JOHN , GIJSEN HENRICUS JACOBUS MARIA
IPC: C07D487/04 , A61K31/519 , A61P25/00 , C07D451/02
Abstract: The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.
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公开(公告)号：AU2017353310A1
公开(公告)日：2019-05-16
申请号：AU2017353310
申请日：2017-10-31
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： VAN ROOSBROECK YVES EMIEL MARIA , VAN DEN KEYBUS FRANS ALFONS MARIA , TRESADERN GARY JOHN , BUIJNSTERS PETER JACOBUS JOHANNES ANTONIUS , VELTER ADRIANA INGRID , JACOBY EDGAR , MACDONALD GREGOR JAMES , GIJSEN HENRICUS JACOBUS MARIA , AHNAOU ABDELLAH , DRINKENBURG WILHELMUS HELENA IGNATIUS MARIA
IPC: C07D487/04 , A61K31/519 , A61P25/00 , C07D519/00
Abstract: The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.
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公开(公告)号：AU2014206834A1
公开(公告)日：2015-05-28
申请号：AU2014206834
申请日：2014-01-16
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： BISCHOFF FRANCOIS PAUL , VELTER ADRIANA INGRID , ROMBOUTS FREDERIK JAN RITA , DE CLEYN MICHEL ANNA JOZEF , VAN BRANDT SVEN FRANCISCUS ANNA , GIJSEN HENRICUS JACOBUS MARIA , ZAVATTARO CHIARA , VAN DEN KEYBUS FRANS ALFONS MARIA
IPC: C07D471/04 , A61K31/498 , A61P25/28
Abstract: The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R
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公开(公告)号：AU2021222332A1
公开(公告)日：2022-10-20
申请号：AU2021222332
申请日：2021-02-18
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： ROMBOUTS FREDERIK JAN RITA , REUILLON TRISTAN , PESCHIULLI ALDO , VELTER ADRIANA INGRID , VOS ANN MARLEEN
IPC: C07D515/22 , A61K31/395 , A61P35/00
Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
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公开(公告)号：AU2017353310B2
公开(公告)日：2021-08-12
申请号：AU2017353310
申请日：2017-10-31
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： VAN ROOSBROECK YVES EMIEL MARIA , VAN DEN KEYBUS FRANS ALFONS MARIA , TRESADERN GARY JOHN , BUIJNSTERS PETER JACOBUS JOHANNES ANTONIUS , VELTER ADRIANA INGRID , JACOBY EDGAR , MACDONALD GREGOR JAMES , GIJSEN HENRICUS JACOBUS MARIA , AHNAOU ABDELLAH , DRINKENBURG WILHELMUS HELENA IGNATIUS MARIA
IPC: C07D487/04 , A61K31/519 , A61P25/00 , C07D519/00
Abstract: The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.
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