-
公开(公告)号：US20180312558A1
公开(公告)日：2018-11-01
申请号：US16018447
申请日：2018-06-26
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Motomu Kanai , Yohei Soma , Atsuhiko Taniguchi , Daisuke Sasaki
CPC classification number: C07K14/4711 , A61K38/00 , C07K1/113
Abstract: The invention provides an Aβ peptide aggregation inhibitor, an Aβ peptide toxicity reducing agent, and a preventive and/or therapeutic agent for Alzheimer's disease. The oxidized Aβ peptide in which one or more amino acid residues of Aβ peptide have been oxidized (excluding an oxidized Aβ peptide in which only Met has been oxidized).
-
公开(公告)号：US11643448B2
公开(公告)日：2023-05-09
申请号：US16018447
申请日：2018-06-26
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Motomu Kanai , Yohei Soma , Atsuhiko Taniguchi , Daisuke Sasaki
CPC classification number: C07K14/4711 , C07K1/113 , A61K38/00
Abstract: The invention provides an Aβ peptide aggregation inhibitor, an Aβ peptide toxicity reducing agent, and a preventive and/or therapeutic agent for Alzheimer's disease. The oxidized Aβ peptide in which one or more amino acid residues of Aβ peptide have been oxidized (excluding an oxidized Aβ peptide in which only Met has been oxidized).
-
公开(公告)号：US09745349B2
公开(公告)日：2017-08-29
申请号：US14648834
申请日：2013-10-18
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Motomu Kanai , Yohei Soma , Tadamasa Arai , Daisuke Sasaki , Yuki Kobayashi
Abstract: A cyclic peptide or a salt thereof of formula (1): X-Leu-Val-Y1-Y2 (1), where X is Lys, Arg, His, Ala, Gly, Ser, or Thr; and Y1 and Y2, which are identical to or different from each other, each represent a group represented by formula (2): where Ar1 represents an aromatic hydrocarbon group or an aromatic heterocyclic group; R1 represents a hydrogen atom, an alkyl group, a cycloalkyl group, a haloalkyl group, an aromatic hydrocarbon group, or an aromatic heterocyclic group; and n is an integer from 0 to 2. In the cyclic peptide has an α-amino group at the amino terminus of the amino acid sequence which is linked, via a peptide bond, to the carboxyl group at the carboxyl terminus of the amino acid sequence.
-
公开(公告)号：US10035831B2
公开(公告)日：2018-07-31
申请号：US14898409
申请日：2014-06-13
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Motomu Kanai , Yohei Soma , Atsuhiko Taniguchi , Daisuke Sasaki
CPC classification number: C07K14/4711 , A61K38/00 , C07K1/113
Abstract: The invention provides an Aβ peptide aggregation inhibitor, an Aβ peptide toxicity reducing agent, and a preventive and/or therapeutic agent for Alzheimer's disease. The oxidized Aβ peptide in which one or more amino acid residues of Aβ peptide have been oxidized (excluding an oxidized Aβ peptide in which only Met has been oxidized).
-
-
-
Search Results
4
records
(took 0.03 seconds)
