公开(公告)号：US09796677B2

公开(公告)日：2017-10-24

申请号：US15100866

申请日：2014-12-09

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Motomu Kanai ,  Yohei Soma ,  Tadamasa Arai ,  Takushi Araya

IPC: A61K31/44 ,  A61K31/505 ,  C07D213/81 ,  C07D239/28 ,  C07D239/30

CPC classification number: C07D213/81 ,  C07D239/30

Abstract: Provided is a novel compound which has an excellent Aβ aggregation inhibitory effect and is useful as a pharmaceutical. An amide compound represented by the formula (1) or a salt thereof, wherein Z represents CH or N; A and B are the same or different and each represents —CH2—, —O—, —S—, or —NH—; R1 and R2 are the same or different and each represents a branched alkyl group, a branched alkenyl group, an optionally substituted aromatic hydrocarbon group, an optionally substituted aralkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aromatic heterocyclic group; and R3 represents a branched alkyl group, a branched alkenyl group, an optionally substituted cycloalkyl group, or an optionally substituted aralkyl group.

公开(公告)号：US09745349B2

公开(公告)日：2017-08-29

申请号：US14648834

申请日：2013-10-18

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Motomu Kanai ,  Yohei Soma ,  Tadamasa Arai ,  Daisuke Sasaki ,  Yuki Kobayashi

IPC: C07K7/64 ,  A61K38/00 ,  C07K7/06

CPC classification number: C07K7/64 ,  A61K38/00 ,  C07K7/06

Abstract: A cyclic peptide or a salt thereof of formula (1): X-Leu-Val-Y1-Y2 (1), where X is Lys, Arg, His, Ala, Gly, Ser, or Thr; and Y1 and Y2, which are identical to or different from each other, each represent a group represented by formula (2): where Ar1 represents an aromatic hydrocarbon group or an aromatic heterocyclic group; R1 represents a hydrogen atom, an alkyl group, a cycloalkyl group, a haloalkyl group, an aromatic hydrocarbon group, or an aromatic heterocyclic group; and n is an integer from 0 to 2. In the cyclic peptide has an α-amino group at the amino terminus of the amino acid sequence which is linked, via a peptide bond, to the carboxyl group at the carboxyl terminus of the amino acid sequence.