公开(公告)号：US20170224773A1

公开(公告)日：2017-08-10

申请号：US15503078

申请日：2015-08-06

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Akio IDO ,  Hirohito TSUBOUCHI ,  Yuga KOMAKI

IPC: A61K38/18 ,  A61L31/16

Abstract: According to this invention, the following are provided: a pharmaceutical composition for treating and/or preventing esophageal stenosis, comprising an HGF protein as an active ingredient (wherein the HGF protein may be a polypeptide that is any one of the following: (a) a polypeptide comprising the amino acid sequence shown in SEQ ID NO: 2; (b) a polypeptide comprising an amino acid sequence shown in SEQ ID NO: 2 in which one to several amino acids are deleted, substituted, or added; or (c) a polypeptide comprising an amino acid sequence having at least 90% identity with the amino acid sequence shown in SEQ ID NO: 2; and a stent comprising the pharmaceutical composition.

公开(公告)号：US20170216444A1

公开(公告)日：2017-08-03

申请号：US15514886

申请日：2015-10-19

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Tsutomu TAMAI ,  Takayuki TAKEI ,  Akio IDO ,  Masahiro YOSHIDA ,  Shinji SAKAI

IPC: A61K47/42 ,  A61K47/36 ,  A61K47/32 ,  A61K31/555 ,  A61K47/08 ,  A61K38/54 ,  A61K38/44 ,  A61K47/38 ,  A61K47/30

CPC classification number: A61K47/42 ,  A61K9/0019 ,  A61K31/00 ,  A61K31/555 ,  A61K38/44 ,  A61K38/443 ,  A61K38/54 ,  A61K45/00 ,  A61K47/08 ,  A61K47/30 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/46 ,  A61L24/0015 ,  A61L24/04 ,  A61L2300/416 ,  A61L2400/06 ,  A61L2430/36 ,  A61M5/00

Abstract: An object is to provide a preparation for forming emboli highly safe in a living body and capable of retaining and controlled-releasing an anticancer agent, occluding a blood vessel when injected into the blood vessel, unlikely to be washed out and having a controlled decomposition time (i.e., occludes a blood vessel for a while and quickly decomposes to prevent the necrosis of the entire tissues when the function is completed). The preparation for forming emboli according to the present invention comprises a solution comprising a phenolic hydroxyl group-modified polymer represented by the following formula (1): wherein P is a biocompatible polymer, A is a single bond or an —OCO—C2-C4-alkenylene group, a —CONH—C1-C4-alkylene group or an —HNCO—C1-C4-alkylene group, and X is hydrogen or a C1-C3-alkoxy group, a solution comprising at least one selected from a peroxidase, a laccase, a tyrosinase, a catalase and an iron porphyrin complex and a solution comprising hydrogen peroxide.