公开(公告)号：AT229000T

公开(公告)日：2002-12-15

申请号：AT98923095

申请日：1998-06-03

Applicant: KANEKA CORP

Inventor： MATSUO KAZUHIKO ,  MATSUMOTO SHINGO ,  INOUE KENJI

IPC: C07C269/06 ,  C07C271/16 ,  C07C271/22 ,  C07C323/44 ,  C07B41/02 ,  C07B53/00 ,  C07M7/00

Abstract: The present invention has its objects to provide a method for reducing alpha -aminoketone derivatives under mild conditions with high stereoselectivity. This invention is a method for reducing alpha -aminoketone which comprises reacting an alpha -aminoketone derivative of general formula (1) with a compound prepared from an organoaluminum compound of general formula (4), a sulfonic acid derivative of general formula (5), and an alcohol compound of general formula (6) to give an alpha -aminoalcohol derivative of general formula (7).

公开(公告)号：CA2602271A1

公开(公告)日：2006-09-28

申请号：CA2602271

申请日：2006-03-20

Applicant: KANEKA CORP

Inventor： MATSUMOTO SHINGO ,  IZUMIDA MASASHI

IPC: C07F7/18 ,  C07B53/00 ,  C07C45/27 ,  C07C47/19

Abstract: The present invention relates to a method of producing a 3-hydroxybutyraldehyde derivative, particularly an optically active 3-hydroxybutyraldehyde derivative, which is useful as an intermediate of a pharmaceutical agent and the like. The method of the present invention is characterized by converting the 3-hydroxybutyrate derivative to an alcohol derivative by a reduction reaction followed by converting it to a desired aldehyde derivative by an oxidation reaction using a nitroxyl compound and a co-oxidant. In accordance with the present invention, a 3-hydroxybutyraldehyde derivative having high qualities (a low content of alcohol derivatives) can be produced by an easy and convenient method without resorting to a reaction under an extremely low temperature condition.

公开(公告)号：ES2185967T3

公开(公告)日：2003-05-01

申请号：ES97935797

申请日：1997-08-18

Applicant: KANEKA CORP

Inventor： MATSUMOTO SHINGO ,  MATSUO KAZUHIKO ,  SUGAWA TADASHI ,  MOROSHIMA TADASHI ,  INOUE KENJI

IPC: C07C227/02 ,  C07C227/42 ,  C07C229/22 ,  C07C229/34 ,  C07C229/36 ,  C07C269/08 ,  C07C271/18 ,  C07C271/22 ,  C07C303/40 ,  C07C303/44 ,  C07C311/19 ,  C07D209/26 ,  C07D209/48

Abstract: An object of the present invention is to provide a process for producing a beta -amino- alpha -hydroxy acid derivative via efficient and industrially utilizable steps. The present invention provides a process for producing a beta -amino- alpha -hydroxy acid derivative represented by the general formula (2) given below which comprises hydrolyzing an alpha -amino- alpha ', alpha '-dihaloketone derivative of the general formula (1) given below in the presence of a base, followed by protecting the amino group or without protecting the same.

公开(公告)号：ES2193524T3

公开(公告)日：2003-11-01

申请号：ES98917669

申请日：1998-04-24

Applicant: KANEKA CORP

Inventor： AWAJI HIROSHI ,  MATSUMOTO SHINGO ,  INOUE KENJI ,  MATSUO KAZUHIKO

IPC: C07D205/04

Abstract: The present invention has its object to provide a process for producing azetidine-2-carboxylic acid and an intermediate thereof, which is efficient and economical and suited for industrial practice. The present invention is related to a process for producing azetidine-2-carboxylic acid of the following formula (5), which comprises subjecting a 4-oxo-2-azetidinecarboxylic acid derivative represented by the general formula (1) to hydride reduction to give azetidine-2-methanol of the following formula (2), treating the same with an amino-protecting agent to give N-protected azetidine-2-methanol represented by the following general formula (3), treating this with an oxidizing agent to give N-protected azetidine-2-carboxylic acid represented by the following general formula (4) and, further, subjecting the amino-protecting group thereof to elimination.

公开(公告)号：DE69716452D1

公开(公告)日：2002-11-21

申请号：DE69716452

申请日：1997-08-18

Applicant: KANEKA CORP

Inventor： MATSUMOTO SHINGO ,  MATSUO KAZUHIKO ,  SUGAWA TADASHI ,  MOROSHIMA TADASHI ,  INOUE KENJI

IPC: C07C227/02 ,  C07C227/42 ,  C07C229/22 ,  C07C229/34 ,  C07C229/36 ,  C07C269/08 ,  C07C271/18 ,  C07C271/22 ,  C07C303/40 ,  C07C303/44 ,  C07C311/19 ,  C07D209/26 ,  C07D209/48

Abstract: An object of the present invention is to provide a process for producing a beta -amino- alpha -hydroxy acid derivative via efficient and industrially utilizable steps. The present invention provides a process for producing a beta -amino- alpha -hydroxy acid derivative represented by the general formula (2) given below which comprises hydrolyzing an alpha -amino- alpha ', alpha '-dihaloketone derivative of the general formula (1) given below in the presence of a base, followed by protecting the amino group or without protecting the same.

公开(公告)号：IN184319B

公开(公告)日：2000-08-05

申请号：IN952CA1998

申请日：1998-05-28

Applicant: KANEKA CORP

Inventor： MATSUO KAZUHIKO ,  MATSUMOTO SHINGO ,  INOUE KENJI

IPC: C07C269/06 ,  C07C271/16 ,  C07C271/22 ,  C07C89/00 ,  A61K31/00

Abstract: The present invention has its objects to provide a method for reducing alpha -aminoketone derivatives under mild conditions with high stereoselectivity. This invention is a method for reducing alpha -aminoketone which comprises reacting an alpha -aminoketone derivative of general formula (1) with a compound prepared from an organoaluminum compound of general formula (4), a sulfonic acid derivative of general formula (5), and an alcohol compound of general formula (6) to give an alpha -aminoalcohol derivative of general formula (7).

公开(公告)号：DE69811893T2

公开(公告)日：2003-11-27

申请号：DE69811893

申请日：1998-04-24

Applicant: KANEKA CORP

Inventor： AWAJI HIROSHI ,  MATSUMOTO SHINGO ,  INOUE KENJI ,  MATSUO KAZUHIKO

IPC: C07D205/04

Abstract: The present invention has its object to provide a process for producing azetidine-2-carboxylic acid and an intermediate thereof, which is efficient and economical and suited for industrial practice. The present invention is related to a process for producing azetidine-2-carboxylic acid of the following formula (5), which comprises subjecting a 4-oxo-2-azetidinecarboxylic acid derivative represented by the general formula (1) to hydride reduction to give azetidine-2-methanol of the following formula (2), treating the same with an amino-protecting agent to give N-protected azetidine-2-methanol represented by the following general formula (3), treating this with an oxidizing agent to give N-protected azetidine-2-carboxylic acid represented by the following general formula (4) and, further, subjecting the amino-protecting group thereof to elimination.

公开(公告)号：DE69809888D1

公开(公告)日：2003-01-16

申请号：DE69809888

申请日：1998-06-03

Applicant: KANEKA CORP

Inventor： MATSUO KAZUHIKO ,  MATSUMOTO SHINGO ,  INOUE KENJI

IPC: C07C269/06 ,  C07C271/16 ,  C07C271/22 ,  C07C323/44 ,  C07B41/02

Abstract: The present invention has its objects to provide a method for reducing alpha -aminoketone derivatives under mild conditions with high stereoselectivity. This invention is a method for reducing alpha -aminoketone which comprises reacting an alpha -aminoketone derivative of general formula (1) with a compound prepared from an organoaluminum compound of general formula (4), a sulfonic acid derivative of general formula (5), and an alcohol compound of general formula (6) to give an alpha -aminoalcohol derivative of general formula (7).

公开(公告)号：CA2262966A1

公开(公告)日：1998-12-10

申请号：CA2262966

申请日：1998-06-03

Applicant: KANEKA CORP

Inventor： MATSUO KAZUHIKO ,  INOUE KENJI ,  MATSUMOTO SHINGO

IPC: C07C269/06 ,  C07C271/16 ,  C07C271/22 ,  C07C315/04 ,  C07C319/20 ,  C07D307/20 ,  C07C317/28 ,  C07C323/43

Abstract: A process for stereoselectively reducing .alpha.-amino haloketone derivatives under mild conditions, which comprises reacting an .alpha.-amino haloketone derivative of general formula (1) with a compound prepared from an organoaluminum compound of general formula (4), a sulfonic acid derivative of the general formula (5): R6SO3H, and an alcohol compound of the general formula (6): R7OH to yield an .alpha.-amino alcohol derivative of general formula (7).

公开(公告)号：EP0992491A4

公开(公告)日：2000-07-19

申请号：EP98917669

申请日：1998-04-24

Applicant: KANEKA CORP

Inventor： AWAJI HIROSHI ,  MATSUMOTO SHINGO ,  INOUE KENJI ,  MATSUO KAZUHIKO

IPC: C07D205/04

CPC classification number: C07D205/04 ,  Y02P20/55

Abstract: Efficient and economical processes for producing azetidine-2-carboxylic acid and intermediates thereof on an industrial scale. Azetidine-2-carboxylic acid of structural formula (5) is produced by reducing a 4-oxo-2-azetidinecarboxylic acid derivative of general formula (1) to form azetidine-2-methanol of structural formula (2), treating this compound with an amino-protecting agent to form an N-protected azetidine-2-methanol of general formula (3), treating this compound with an oxidizing agent to form an N-protected azetidine-2-carboxylic acid of general formula (4), and removing the amino-protecting group.