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    METHOD FOR PRODUCING N-ALKOXYCARBONYL-tert-LEUCINE
    3.
    发明专利
    METHOD FOR PRODUCING N-ALKOXYCARBONYL-tert-LEUCINE 有权
    生产N-烷氧羰基 - 叔丁醇的方法

    公开(公告)号：JP2009242288A

    公开(公告)日：2009-10-22

    申请号：JP2008090257

    申请日：2008-03-31

    Applicant: Kaneka Corp ,  株式会社カネカ

    Inventor： HIRAI YOSHINORI ,  MAEHARA KATSUHARU ,  MOROSHIMA TADASHI

    IPC: C07C269/04 ,  C07C271/22

    Abstract: PROBLEM TO BE SOLVED: To find a method for efficiently and stably producing an N-alkoxycarbonyl-tert-leucine of high quality by a simple operation. SOLUTION: The N-alkoxycarbonyl-tert-leucine is produced by causing an N-alkoxycarbonylation agent in an amount of at least 0.90 molar time and at most 1.00 molar time the amount of tert-leucine to react with tert-leucine in the presence of water while controlling the pH of the solution within the range of 9-13 by using a basic reagent. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 待解决的问题：通过简单的操作找到高效稳定地制备高品质的N-烷氧基羰基 - 叔亮氨酸的方法。 解决方案：N-烷氧基羰基 - 叔亮氨酸是通过使N-烷氧基羰基化剂以至少0.90摩尔倍数和至多1.00摩尔倍的量与叔 - 亮氨酸反应的量与 通过使用碱性试剂将溶液的pH值控制在9-13的范围内。 版权所有（C）2010，JPO＆INPIT

    5.
    发明专利
    未知

    公开(公告)号：DE69934084T2

    公开(公告)日：2007-04-05

    申请号：DE69934084

    申请日：1999-09-22

    Applicant: KANEKA CORP

    Inventor： MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

    IPC: C07K5/068 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02 ,  C07K5/06

    Abstract: The process for producing N -(1(S)-carboxy-3-phenylpropyl)-L-lysyl-L-proline in a simple, efficient and industrially advantageous manner, which comprises: the first step of subjecting the N -(1(S)-alkoxycarbonyl-3-phenylpropyl)-N -trifluoroacetyl-L-lysyl -L-proline (1) to alkali hydrolysis in a mixed solution composed of water and a hydrophilic organic solvent using an inorganic base in an amount of n molar equivalents (n >/= 3) per mole of the above compound (1), the second step of neutralizing the hydrolysis product using an inorganic acid in an amount of (n - 1) to n molar equivalents (n >/= 3) and removing the inorganic salt formed by causing the same to precipitate out from a solvent system suited for decreasing the solubility of the inorganic salt, and the third step of causing the compound (2) existing in the mixture after removal of the inorganic salt to crystallize out at the isoelectric point thereof and thereby recovering the compound (2) in the form of crystals while retaining the salts comprising the trifluoroacetic acid-derived organic acid salt in a state dissolved in the mother liquor.

    6.
    发明专利
    未知

    公开(公告)号：DE60207233T2

    公开(公告)日：2006-07-13

    申请号：DE60207233

    申请日：2002-05-10

    Applicant: KANEKA CORP

    Inventor： MOROSHIMA TADASHI ,  UEDA YASUYOSHI

    IPC: C07D301/32 ,  C07D301/03 ,  C07D301/36 ,  C07D303/08

    Abstract: The present invention provides a method capable of suppressing a decrease in optical purity due to the exposure to heat during distillation of an optically active epoxide to permit an optically active epoxide of high quality to be simply obtained on an industrial scale. In the method, an optically active epoxide is distilled in the presence of a base to suppress a decrease in optical purity.

    7.
    发明专利
    未知

    公开(公告)号：AT309234T

    公开(公告)日：2005-11-15

    申请号：AT02724758

    申请日：2002-05-10

    Applicant: KANEKA CORP

    Inventor： MOROSHIMA TADASHI ,  UEDA YASUYOSHI

    IPC: C07D301/03 ,  C07D301/32 ,  C07D301/36 ,  C07D303/08

    Abstract: The present invention provides a method capable of suppressing a decrease in optical purity due to the exposure to heat during distillation of an optically active epoxide to permit an optically active epoxide of high quality to be simply obtained on an industrial scale. In the method, an optically active epoxide is distilled in the presence of a base to suppress a decrease in optical purity.

    Process for the preparation of N2 -(1(S)-carboxy-3-phenylpropyl)-L-lysyl-L-proline
    9.
    发明专利
    Process for the preparation of N2 -(1(S)-carboxy-3-phenylpropyl)-L-lysyl-L-proline 未知

    公开(公告)号：CZ292494B6

    公开(公告)日：2003-10-15

    申请号：CZ20001897

    申请日：1999-09-22

    Applicant: KANEKA CORP

    Inventor： MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

    IPC: C07K5/068 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02

    Abstract: The present invention relates to a process for the preparation of N2 -(1(S)-carboxy-3-phenylpropyl)-L-lysyl-L-proline in a simple, efficient and industrially advantageous manner, which comprises: the first step of subjecting the Ne2-(1(S)-alkoxycarbonyl-3-phenylpropyl)-Ne6-trifluorocetyl-L-lysyl-L-proline (1) to alkali hydrolysis in a mixed solution composed of water and a hydrophilic organic solvent using an inorganic base, the second step of neutralizing the hydrolysis product using an inorganic acid and removing the inorganic salt formed by causing the same to precipitate out from a solvent system suited for decreasing the solubility of the inorganic salt, and the third step of causing the final product existing in the mixture after removal of the inorganic salt to crystallize out at the isoelectric point thereof and thereby recovering the Ne2-(1(S)-carboxy-3-phenylpropyl)-L-lysyl-L-proline in the form of crystals while retaining the salts comprising the trifluoroacetic acid-derived organic acid salt in a state dissolved in the mother liquor.

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