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    1.
    发明专利
    未知

    公开(公告)号：DE69831950T2

    公开(公告)日：2006-07-20

    申请号：DE69831950

    申请日：1998-06-25

    Applicant: KANEKA CORP

    Inventor： YOKOTA SHIN-ICHI ,  YAMAMOTO KOZO ,  MORIKAWA SOUICHI ,  FUSE YOSHIHIDE ,  KITAHARA MIKIO

    IPC: C07D405/06 ,  A61K31/40 ,  A61K31/445

    Abstract: A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

    6.
    发明专利
    未知

    公开(公告)号：DE602005012127D1

    公开(公告)日：2009-02-12

    申请号：DE602005012127

    申请日：2005-08-01

    Applicant: KANEKA CORP

    Inventor： KIZAKI NORIYUKI ,  YANO MIHO ,  FUNAKI MASAHIRO ,  TAKESUE TERUAKI ,  YASOHARA YOSHIHIKO ,  MORIKAWA SOUICHI ,  NAKAI TAKAHISA ,  KATAOKA MICHIHIKO ,  SHIMIZU SAKAYU

    IPC: C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/04 ,  C12P13/00

    Abstract: The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging to the genus Ogataea, a DNA encoding the polypeptide and a transformant that produces the polypeptide. The present invention moreover relates to a method of producing (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol utilizing the polypeptide or the transformant. Using the polypeptide or transformant of the present invention, optically active alcohols such as (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol and the like can be produced efficiently.

    Heat shock factor activity inhibitors
    9.
    发明专利
    Heat shock factor activity inhibitors 未知

    公开(公告)号：AU7933298A

    公开(公告)日：1999-01-19

    申请号：AU7933298

    申请日：1998-06-25

    Applicant: KANEKA CORP

    Inventor： YOKOTA SHINICHI ,  YAMAMOTO KOZO ,  MORIKAWA SOUICHI ,  FUSE YOSHIHIDE ,  KITAHARA MIKIO

    IPC: C07D405/06 ,  A61K31/40 ,  A61K31/445

    Abstract: A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

    STEREOSTRUCTURE OF DECARBAMYLASE AND METHOD OF USING THE SAME
    10.
    发明公开
    STEREOSTRUCTURE OF DECARBAMYLASE AND METHOD OF USING THE SAME 审中-公开
    FOR USE脱和方法的立体结构

    公开(公告)号：EP1209234A4

    公开(公告)日：2003-05-02

    申请号：EP00956828

    申请日：2000-08-30

    Applicant: KANEKA CORP

    Inventor： NAKAI TAKAHISA ,  MORIKAWA SOUICHI ,  ISHII KIYOTO ,  NANBA HIROKAZU ,  YAJIMA KAZUYOSHI ,  IKENAKA YASUHIRO ,  TAKAHASHI SATOMI

    IPC: C12N15/09 ,  C12N9/80 ,  C12N9/88 ,  C12N15/60 ,  G06F17/30

    CPC classification number: C12N9/80

    Abstract: Excellent decarbamylase variants which are more advantageously usable industrially are provided by clarifying the stereostructure of decarbamylase by X-ray crystalline structure analysis and designing molecules aiming at elevating the reactivity to the substrates (D-N-carbamoyl- alpha -amino acids), etc. by using the stereostructure. More particularly speaking, provision is made of: the stereostructure of decarbamylase determined by X-ray crystalline structure analysis, stereostructure models of variants thereof and stereostructure models of complexes thereof with substrates, products, etc.; a molecular design method with the use of these stereostructures; a method of obtaining decarbamylase variants by using this method; the decarbamylase variants obtained by this method; and a method of designing and producing variants of proteins which are similar to decarbamylase in structure.

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