公开(公告)号：EP0995745A4

公开(公告)日：2002-11-06

申请号：EP98929672

申请日：1998-06-25

Applicant: KANEKA CORP

Inventor： YOKOTA SHIN-ICHI ,  YAMAMOTO KOZO ,  MORIKAWA SOUICHI ,  FUSE YOSHIHIDE ,  KITAHARA MIKIO

IPC: C07D405/06 ,  A61K31/40 ,  A61K31/445

CPC classification number: C07D405/06

Abstract: Remedies for diseases which function by regulating the expression of a protein induced by a heat shock factor (HSF). Specifically, HSF activity inhibitors or agents inhibiting the induction of the production of a protein regulated by HSF, wherein novel benzo-1,3-dioxole compounds represented by general formula (I) inhibit the transcription of a structural gene having a heat shock element sequence, which is a transcriptional regulatory factor, in a gene region participating in the transcription into RNA, thus inhibit the translation of this gene into a protein and, in its turn, suppress the induction of the production of the RNA, protein, etc. encoded by the gene; and remedies and preventives usable in thermotherapy for cancer and remedies and preventives for stress-induced diseases such as depression. Compounds represented by general formula (I): wherein X is -CH2- and R1 represents C¿1-2? alkyl, formyl or halogeno; or X is -(CH2)2- and R?1¿ represents C¿1-3? alkyl, formyl, acetyl, hydrogen or halogeno.

公开(公告)号：AU7933298A

公开(公告)日：1999-01-19

申请号：AU7933298

申请日：1998-06-25

Applicant: KANEKA CORP

Inventor： YOKOTA SHINICHI ,  YAMAMOTO KOZO ,  MORIKAWA SOUICHI ,  FUSE YOSHIHIDE ,  KITAHARA MIKIO

IPC: C07D405/06 ,  A61K31/40 ,  A61K31/445

Abstract: A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

公开(公告)号：DE69831950T2

公开(公告)日：2006-07-20

申请号：DE69831950

申请日：1998-06-25

Applicant: KANEKA CORP

Inventor： YOKOTA SHIN-ICHI ,  YAMAMOTO KOZO ,  MORIKAWA SOUICHI ,  FUSE YOSHIHIDE ,  KITAHARA MIKIO

IPC: C07D405/06 ,  A61K31/40 ,  A61K31/445

Abstract: A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

公开(公告)号：CA2295055A1

公开(公告)日：1999-01-07

申请号：CA2295055

申请日：1998-06-25

Applicant: KANEKA CORP

Inventor： YOKOTA SHIN-ICHI ,  KITAHARA MIKIO ,  FUSE YOSHIHIDE ,  MORIKAWA SOUICHI ,  YAMAMOTO KOZO

IPC: C07D405/06 ,  A61K31/40 ,  A61K31/445

Abstract: Remedies for diseases which function by regulating the expression of a protein induced by a heat shock factor (HSF). Specifically, HSF activity inhibitors or agents inhibiting the induction of the production of a protein regulated by HSF, wherein novel benzo-1,3-dioxole compounds represented by general formula (I) inhibit the transcription of a structural gene having a heat shock element sequence, which is a transcriptional regulatory factor, in a gene region participating in the transcription into RNA, thus inhibit the translation of this gene into a protein and, in its turn, suppress the induction of the production of the RNA, protein, etc. encoded by the gene; and remedies and preventives usable in thermotherapy for cancer and remedies and preventives for stress-induced diseases such as depression. Compounds represented by general formula (I): wherein X is -CH2- and R1 represents C1-2 alkyl, formyl or halogeno; or X is -(CH2)2- and R1 represents C1-3 alkyl, formyl, acetyl, hydrogen or halogeno.

公开(公告)号：DE69831950D1

公开(公告)日：2006-03-02

申请号：DE69831950

申请日：1998-06-25

Applicant: KANEKA CORP

Inventor： YOKOTA SHIN-ICHI ,  YAMAMOTO KOZO ,  MORIKAWA SOUICHI ,  FUSE YOSHIHIDE ,  KITAHARA MIKIO

IPC: A61K31/40 ,  A61K31/445 ,  C07D405/06

Abstract: A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.