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    HEAT SHOCK FACTOR ACTIVITY INHIBITOR
    3.
    发明专利
    HEAT SHOCK FACTOR ACTIVITY INHIBITOR 未知

    公开(公告)号：CA2295055A1

    公开(公告)日：1999-01-07

    申请号：CA2295055

    申请日：1998-06-25

    Applicant: KANEKA CORP

    Inventor： YOKOTA SHIN-ICHI ,  KITAHARA MIKIO ,  FUSE YOSHIHIDE ,  MORIKAWA SOUICHI ,  YAMAMOTO KOZO

    IPC: C07D405/06 ,  A61K31/40 ,  A61K31/445

    Abstract: Remedies for diseases which function by regulating the expression of a protein induced by a heat shock factor (HSF). Specifically, HSF activity inhibitors or agents inhibiting the induction of the production of a protein regulated by HSF, wherein novel benzo-1,3-dioxole compounds represented by general formula (I) inhibit the transcription of a structural gene having a heat shock element sequence, which is a transcriptional regulatory factor, in a gene region participating in the transcription into RNA, thus inhibit the translation of this gene into a protein and, in its turn, suppress the induction of the production of the RNA, protein, etc. encoded by the gene; and remedies and preventives usable in thermotherapy for cancer and remedies and preventives for stress-induced diseases such as depression. Compounds represented by general formula (I): wherein X is -CH2- and R1 represents C1-2 alkyl, formyl or halogeno; or X is -(CH2)2- and R1 represents C1-3 alkyl, formyl, acetyl, hydrogen or halogeno.

    6.
    发明专利
    未知

    公开(公告)号：AT433757T

    公开(公告)日：2009-07-15

    申请号：AT03745912

    申请日：2003-04-04

    Applicant: KANEKA CORP

    Inventor： IKEHARA TOSHINORI ,  KITAHARA MIKIO

    IPC: A23D9/00 ,  A61K36/484 ,  A23L1/30 ,  A23L27/10 ,  A61K47/14 ,  A61P1/06 ,  A61P11/10 ,  A61P25/04

    Abstract: Method of making a lipid composition containing Glycyrrhiza hydrophobic components comprises extracting the plant with a lipid solvent (L) containing at least 10 wt.% lipid soluble polyhydric alcohol fatty acid ester(s) (FAE). Independent claims are also included for: (a) a composition obtained by the method; and (b) a lipid foodstuff containing the composition.

    7.
    发明专利
    未知

    公开(公告)号：DE69831950D1

    公开(公告)日：2006-03-02

    申请号：DE69831950

    申请日：1998-06-25

    Applicant: KANEKA CORP

    Inventor： YOKOTA SHIN-ICHI ,  YAMAMOTO KOZO ,  MORIKAWA SOUICHI ,  FUSE YOSHIHIDE ,  KITAHARA MIKIO

    IPC: A61K31/40 ,  A61K31/445 ,  C07D405/06

    Abstract: A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

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