公开(公告)号：DE69829905D1

公开(公告)日：2005-06-02

申请号：DE69829905

申请日：1998-02-27

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  YAMANE TAKEHIKO ,  SAKASHITA SHINICHI ,  SAKA YASUHIRO ,  HOSOE KAZUNORI ,  FUJII KENJI

IPC: A61K31/5383 ,  A61K31/542 ,  A61K31/395 ,  A61P1/00

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter, comprising a rifamycin derivative expressed by the formula (I), or a physiologically acceptable salt thereof.

公开(公告)号：CA2230649C

公开(公告)日：2007-11-06

申请号：CA2230649

申请日：1998-02-27

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  SAKASHITA SHINICHI ,  YAMASHITA KATSUJI ,  FUJII KENJI ,  YAMANE TAKEHIKO ,  HOSOE KAZUNORI

IPC: A61K31/54 ,  A61K31/395 ,  A61K31/535 ,  A61K31/5383 ,  A61K31/542

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter, comprising a rifamycin derivative expressed by the formula (I), or a physiologically acceptable salt thereof.

公开(公告)号：CA2230649A1

公开(公告)日：1998-08-28

申请号：CA2230649

申请日：1998-02-27

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  YAMANE TAKEHIKO ,  YAMASHITA KATSUJI ,  SAKASHITA SHINICHI ,  FUJII KENJI ,  HOSOE KAZUNORI

IPC: A61K31/5383 ,  A61K31/542 ,  A61K31/54 ,  A61K31/395 ,  A61K31/535

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter, comprising a rifamycin derivative expressed by the formula (I), or a physiologically acceptable salt thereof. (see fig. I)

公开(公告)号：ES2237809T3

公开(公告)日：2005-08-01

申请号：ES98103481

申请日：1998-02-27

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  YAMANE TAKEHIKO ,  SAKASHITA SHINICHI ,  SAKA YASUHIRO ,  HOSOE KAZUNORI ,  FUJII KENJI

IPC: A61K31/5383 ,  A61K31/542 ,  A61K31/395 ,  A61P1/00

Abstract: MEDICINA CURATIVA PARA UNA ENFERMEDAD DIGESTIVA CAUSADA POR LA INFECCION POR HELICOBACTER, CONSTITUIDA POR UN DERIVADO DE LA RIFAMICINA QUE RESPONDE A LA FORMULA (I), O UNA SAL DE ESTE FISIOLOGICAMENTE ACEPTABLE.

公开(公告)号：CA2204007A1

公开(公告)日：1997-03-13

申请号：CA2204007

申请日：1996-08-29

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  SAKASHITA SHINICHI ,  YAMANE TAKEHIKO ,  HOSOE KAZUNORI ,  FUJII KENJI

IPC: A61K31/438 ,  A61K31/536 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/535 ,  A61K31/445 ,  A61K31/54

Abstract: A remedy for digestive diseases caused by the infection with Helicobacter which comprises as the active ingredient rifamycin derivatives represented by general formula (I) or (II) or physiologically acceptable salts thereof.

公开(公告)号：DE69632677T2

公开(公告)日：2005-06-16

申请号：DE69632677

申请日：1996-08-29

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  YAMANE TAKEHIKO ,  SAKASHITA SHINICHI ,  HOSOE KAZUNORI ,  FUJII KENJI

IPC: A61K31/438 ,  A61K31/536 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/535 ,  A61K31/54 ,  C07D498/18 ,  C07D513/18 ,  A61P31/04

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter comprising as an effective component a rifamycin derivative expressed by the formula (I) or the formula (II), or a physiologically acceptable salt thereof. In the formula (I), X represents an oxygen atom or a sulfur atom, R represents an acetyl group or a hydrogen atom, R represents a hydroxy group or a hydrogen atom, R represents Äin which R and R are the same or different and each is an alkyl group having 1 to 3 carbon atoms or a group expressed by the formula (in which m represents an integer between 1 and 3)Ü, or Äin which R and R are the same or different and each is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, X represents an oxygen atom or a sulfur atom or NR äR represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or -(CH2)nX (in which n represents an integer between 1 and 4, and X represents an alkoxy group having of 1 to 3 carbon atoms, or a vinyl group or an ethynyl group, or a group expressed by the formula In the formula (II), R represents an alkyl group having 1 to 7 carbon atoms.

公开(公告)号：DE69916968T2

公开(公告)日：2005-04-07

申请号：DE69916968

申请日：1999-11-02

Applicant: KANEKA CORP

Inventor： GOTO MASAOKI ,  SAKASHITA SHINICHI ,  MATSUMURA KUNIHIKO

IPC: A45D7/04 ,  A61K8/00 ,  A61K8/65 ,  A61Q5/00 ,  A61Q5/04 ,  C07D303/04 ,  C07D303/16 ,  C07D303/22 ,  D01F4/00 ,  D06M13/02 ,  D06M13/11 ,  D06M13/248 ,  D06M13/272 ,  D06M13/325 ,  D06M13/332 ,  D06M101/00 ,  D06M101/02 ,  D06M101/10 ,  D06M101/14

Abstract: A regenerated collagen fiber is subjected to water-insolubilizing treatment with a monofunctional epoxy compound to produce a water-insolubilized regenerated collagen fiber which can substantially maintain the color and the high knot tenacity, inherent in the collagen. Where the monofunctional epoxy compound is an epihalohydrin, a regenerated collagen fiber can be treated with this epihalohydrin and a sulfur compound to produce a water-insolubilized regenerated collagen fiber which can be permanent-wave set. In addition, the water-insolubilized regenerated collagen fiber can be converted into a fiber which can be permanent-wave set, by introducing a disulfide linkage into carboxylic groups of the collagen, which remain unmodified by the insolubilizing treatment.

公开(公告)号：DE69632677D1

公开(公告)日：2004-07-15

申请号：DE69632677

申请日：1996-08-29

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  YAMANE TAKEHIKO ,  SAKASHITA SHINICHI ,  HOSOE KAZUNORI ,  FUJII KENJI

IPC: A61K31/438 ,  A61K31/536 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/535 ,  A61K31/54 ,  C07D498/18 ,  C07D513/18 ,  A61P31/04

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter comprising as an effective component a rifamycin derivative expressed by the formula (I) or the formula (II), or a physiologically acceptable salt thereof. In the formula (I), X represents an oxygen atom or a sulfur atom, R represents an acetyl group or a hydrogen atom, R represents a hydroxy group or a hydrogen atom, R represents Äin which R and R are the same or different and each is an alkyl group having 1 to 3 carbon atoms or a group expressed by the formula (in which m represents an integer between 1 and 3)Ü, or Äin which R and R are the same or different and each is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, X represents an oxygen atom or a sulfur atom or NR äR represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or -(CH2)nX (in which n represents an integer between 1 and 4, and X represents an alkoxy group having of 1 to 3 carbon atoms, or a vinyl group or an ethynyl group, or a group expressed by the formula In the formula (II), R represents an alkyl group having 1 to 7 carbon atoms.

公开(公告)号：DE69829905T2

公开(公告)日：2006-03-09

申请号：DE69829905

申请日：1998-02-27

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  YAMANE TAKEHIKO ,  SAKASHITA SHINICHI ,  SAKA YASUHIRO ,  HOSOE KAZUNORI ,  FUJII KENJI

IPC: A61K31/395 ,  A61K31/5383 ,  A61K31/542 ,  A61P1/00

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter, comprising a rifamycin derivative expressed by the formula (I), or a physiologically acceptable salt thereof.

公开(公告)号：ES2218597T3

公开(公告)日：2004-11-16

申请号：ES96928723

申请日：1996-08-29

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  YAMANE TAKEHIKO ,  SAKASHITA SHINICHI ,  HOSOE KAZUNORI ,  FUJII KENJI

IPC: A61K31/438 ,  A61K31/536 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/535 ,  A61K31/54 ,  C07D498/18 ,  C07D513/18 ,  A61P31/04

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter comprising as an effective component a rifamycin derivative expressed by the formula (I) or the formula (II), or a physiologically acceptable salt thereof. In the formula (I), X represents an oxygen atom or a sulfur atom, R represents an acetyl group or a hydrogen atom, R represents a hydroxy group or a hydrogen atom, R represents Äin which R and R are the same or different and each is an alkyl group having 1 to 3 carbon atoms or a group expressed by the formula (in which m represents an integer between 1 and 3)Ü, or Äin which R and R are the same or different and each is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, X represents an oxygen atom or a sulfur atom or NR äR represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or -(CH2)nX (in which n represents an integer between 1 and 4, and X represents an alkoxy group having of 1 to 3 carbon atoms, or a vinyl group or an ethynyl group, or a group expressed by the formula In the formula (II), R represents an alkyl group having 1 to 7 carbon atoms.