公开(公告)号：DE69829905D1

公开(公告)日：2005-06-02

申请号：DE69829905

申请日：1998-02-27

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  YAMANE TAKEHIKO ,  SAKASHITA SHINICHI ,  SAKA YASUHIRO ,  HOSOE KAZUNORI ,  FUJII KENJI

IPC: A61K31/5383 ,  A61K31/542 ,  A61K31/395 ,  A61P1/00

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter, comprising a rifamycin derivative expressed by the formula (I), or a physiologically acceptable salt thereof.

公开(公告)号：ES2215624T3

公开(公告)日：2004-10-16

申请号：ES00915524

申请日：2000-04-14

Applicant: KANEKA CORP

Inventor： KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  NAGASHIMA NOBUO ,  SAKA YASUHIRO ,  HONDA TATSUYA

IPC: C07C29/147 ,  C07C31/42 ,  C07D307/20

Abstract: The application is concerned with a process for producing a 3-hydroxytetrahydrofuran of the formula (3): by cyclizing a 4-halo-1,3-butanediol of the general formula (2): wherein X represents a halogen atom in an aqueous solution, which comprises carrying out the cyclization reaction under weakly acidic to neutral conditions. Furthermore several methods are disclosed for the isolution of highly pure 3-hydroxytetrahydrofuran.

公开(公告)号：CA2230649C

公开(公告)日：2007-11-06

申请号：CA2230649

申请日：1998-02-27

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  SAKASHITA SHINICHI ,  YAMASHITA KATSUJI ,  FUJII KENJI ,  YAMANE TAKEHIKO ,  HOSOE KAZUNORI

IPC: A61K31/54 ,  A61K31/395 ,  A61K31/535 ,  A61K31/5383 ,  A61K31/542

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter, comprising a rifamycin derivative expressed by the formula (I), or a physiologically acceptable salt thereof.

公开(公告)号：ES2234802T3

公开(公告)日：2005-07-01

申请号：ES01902737

申请日：2001-02-02

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  HONDA TATSUYA ,  NAGASHIMA NOBUO

IPC: C07D205/04

Abstract: Procedimiento para la producción del ácido azetidin-2-carboxílico ópticamente activo de fórmula general (2): en la fórmula, * indica un átomo de carbono asimétrico, que comprende ciclar un ácido 4-amino-2- halogenobutírico ópticamente activo de fórmula general (1): en la fórmula, X representa un átomo de halógeno y * indica un átomo de carbono asimétrico, en presencia de un óxido de un metal alcalinotérreo, hidróxido de magnesio o una amina orgánica.

公开(公告)号：DE60008334T2

公开(公告)日：2004-11-25

申请号：DE60008334

申请日：2000-04-14

Applicant: KANEKA CORP

Inventor： KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  NAGASHIMA NOBUO ,  SAKA YASUHIRO ,  HONDA TATSUYA ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C29/147 ,  C07C31/42 ,  C07D307/20

Abstract: The application is concerned with a process for producing a 3-hydroxytetrahydrofuran of the formula (3): by cyclizing a 4-halo-1,3-butanediol of the general formula (2): wherein X represents a halogen atom in an aqueous solution, which comprises carrying out the cyclization reaction under weakly acidic to neutral conditions. Furthermore several methods are disclosed for the isolution of highly pure 3-hydroxytetrahydrofuran.

公开(公告)号：NO20015042D0

公开(公告)日：2001-10-16

申请号：NO20015042

申请日：2001-10-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  G01N

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

公开(公告)号：CA2230649A1

公开(公告)日：1998-08-28

申请号：CA2230649

申请日：1998-02-27

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  YAMANE TAKEHIKO ,  YAMASHITA KATSUJI ,  SAKASHITA SHINICHI ,  FUJII KENJI ,  HOSOE KAZUNORI

IPC: A61K31/5383 ,  A61K31/542 ,  A61K31/54 ,  A61K31/395 ,  A61K31/535

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter, comprising a rifamycin derivative expressed by the formula (I), or a physiologically acceptable salt thereof. (see fig. I)

公开(公告)号：DE60108355D1

公开(公告)日：2005-02-17

申请号：DE60108355

申请日：2001-02-02

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  HONDA TATSUYA ,  NAGASHIMA NOBUO

IPC: C07D205/04

公开(公告)号：DE60008334D1

公开(公告)日：2004-03-25

申请号：DE60008334

申请日：2000-04-14

Applicant: KANEKA CORP

Inventor： KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  NAGASHIMA NOBUO ,  SAKA YASUHIRO ,  HONDA TATSUYA ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C29/147 ,  C07C31/42 ,  C07D307/20

Abstract: The application is concerned with a process for producing a 3-hydroxytetrahydrofuran of the formula (3): by cyclizing a 4-halo-1,3-butanediol of the general formula (2): wherein X represents a halogen atom in an aqueous solution, which comprises carrying out the cyclization reaction under weakly acidic to neutral conditions. Furthermore several methods are disclosed for the isolution of highly pure 3-hydroxytetrahydrofuran.

公开(公告)号：CZ20014121A3

公开(公告)日：2002-10-16

申请号：CZ20014121

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  C07C227/04 ,  C07C227/26 ,  C07B53/00

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.