公开(公告)号：EP0787494A4

公开(公告)日：2000-04-26

申请号：EP96928723

申请日：1996-08-29

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  YAMANE TAKEHIKO ,  SAKASHITA SHINICHI ,  HOSOE KAZUNORI ,  FUJII KENJI

IPC: A61K31/438 ,  A61K31/536 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/535 ,  A61K31/54 ,  C07D498/18 ,  C07D513/18

CPC classification number: A61K31/541 ,  A61K31/438 ,  A61K31/536 ,  A61K31/5383 ,  A61K31/542

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter comprising as an effective component a rifamycin derivative expressed by the formula (I) or the formula (II), or a physiologically acceptable salt thereof. In the formula (I), X represents an oxygen atom or a sulfur atom, R represents an acetyl group or a hydrogen atom, R represents a hydroxy group or a hydrogen atom, R represents Äin which R and R are the same or different and each is an alkyl group having 1 to 3 carbon atoms or a group expressed by the formula (in which m represents an integer between 1 and 3)Ü, or Äin which R and R are the same or different and each is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, X represents an oxygen atom or a sulfur atom or NR äR represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or -(CH2)nX (in which n represents an integer between 1 and 4, and X represents an alkoxy group having of 1 to 3 carbon atoms, or a vinyl group or an ethynyl group, or a group expressed by the formula In the formula (II), R represents an alkyl group having 1 to 7 carbon atoms.

公开(公告)号：CA2321265C

公开(公告)日：2009-10-13

申请号：CA2321265

申请日：1999-02-17

Applicant: KANEKA CORP

Inventor： FUJII KENJI ,  YAMASHITA KATSUJI ,  HOSOE KAZUNORI ,  HIDAKA TAKAYOSHI

IPC: A61K31/538 ,  A61K31/395 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/5415 ,  A61K31/60 ,  A61K33/24 ,  A61K45/00 ,  A61P1/00 ,  A61P1/04 ,  A61P31/04

Abstract: Antibacterial compositions comprising (1) a rifamycin derivative represented by the formula (I) or its physiologically acceptable salt, and (2) a proton pump inhibitor (a) or a bismuth preparation (b) wherein the components (1) and (2) are used in such amounts as producing a synergistic effect against Helicobacter pylori, drugs and remedies for digestive organ diseases which contain the antibacterial compositions, process for producing them, and pharmaceutical preparations related to the antibacterial compositions. The compositions can be administered to patients with digestive diseases caused by infection of Helicobacter pylori in a smaller dose and at a lower administration frequency as compared with conventional remedies.

公开(公告)号：CA2230649C

公开(公告)日：2007-11-06

申请号：CA2230649

申请日：1998-02-27

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  SAKASHITA SHINICHI ,  YAMASHITA KATSUJI ,  FUJII KENJI ,  YAMANE TAKEHIKO ,  HOSOE KAZUNORI

IPC: A61K31/54 ,  A61K31/395 ,  A61K31/535 ,  A61K31/5383 ,  A61K31/542

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter, comprising a rifamycin derivative expressed by the formula (I), or a physiologically acceptable salt thereof.

公开(公告)号：CA2321265A1

公开(公告)日：1999-09-02

申请号：CA2321265

申请日：1999-02-17

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  FUJII KENJI ,  HOSOE KAZUNORI ,  HIDAKA TAKAYOSHI

IPC: A61K31/395 ,  A61K31/415 ,  A61K31/44 ,  A61K31/60 ,  A61K33/24 ,  A61K45/00 ,  A61K31/535 ,  C07D498/18 ,  A61K31/54

Abstract: Antimicrobial compositions containing (1) a rifamycin derivative represented by formula (I) or a physiologically acceptable salt thereof, and (2) (a) a proton pump inhibitor or (b) a bismuth preparation, wherein the components (1) and (2) are used in such amounts as to achieve a synergistic effect. These compositions can be administered to patients with digestive diseases induced by the infection with Helicobacter pylori in a small dose and at a low administration frequency compared with the cases of the conventional remedies

公开(公告)号：CA2230649A1

公开(公告)日：1998-08-28

申请号：CA2230649

申请日：1998-02-27

Applicant: KANEKA CORP

Inventor： SAKA YASUHIRO ,  YAMANE TAKEHIKO ,  YAMASHITA KATSUJI ,  SAKASHITA SHINICHI ,  FUJII KENJI ,  HOSOE KAZUNORI

IPC: A61K31/5383 ,  A61K31/542 ,  A61K31/54 ,  A61K31/395 ,  A61K31/535

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter, comprising a rifamycin derivative expressed by the formula (I), or a physiologically acceptable salt thereof. (see fig. I)

公开(公告)号：ES2237809T3

公开(公告)日：2005-08-01

申请号：ES98103481

申请日：1998-02-27

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  YAMANE TAKEHIKO ,  SAKASHITA SHINICHI ,  SAKA YASUHIRO ,  HOSOE KAZUNORI ,  FUJII KENJI

IPC: A61K31/5383 ,  A61K31/542 ,  A61K31/395 ,  A61P1/00

Abstract: MEDICINA CURATIVA PARA UNA ENFERMEDAD DIGESTIVA CAUSADA POR LA INFECCION POR HELICOBACTER, CONSTITUIDA POR UN DERIVADO DE LA RIFAMICINA QUE RESPONDE A LA FORMULA (I), O UNA SAL DE ESTE FISIOLOGICAMENTE ACEPTABLE.

公开(公告)号：CA2192255C

公开(公告)日：2004-07-13

申请号：CA2192255

申请日：1996-12-06

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  HOSOE KAZUNORI ,  TODARO GEORGE ,  SHAWAR RIBHI M ,  HIDAKA TAKAYOSHI

IPC: C07D498/18 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5383 ,  A61K31/54 ,  A61P31/04

Abstract: Treatment of diseases caused by Chlamydia infection by a rifamycin derivative of the formula (I): (see formula I) wherein R1 is hydrogen atom or acetyl group, and X is oxygen atom, sulfur atom or a group NR in which R is hydrogen atom, an alkyl group having 1 to 7 carbon atoms or a group of the formula (II): (see formula II) in which n is an integer of 1 to 3; or a physiologically acceptable salt thereof.

公开(公告)号：NZ503027A

公开(公告)日：2002-10-25

申请号：NZ50302798

申请日：1998-07-29

Applicant: KANEKA CORP

Inventor： FUJII KENJI ,  YAMASHITA KATSUJI ,  HOSOE KAZUNORI ,  YANCEY ROBERT J ,  WATTS JEFFREY L

IPC: A61K31/5383 ,  A61P31/04 ,  A61K31/535

Abstract: A method for treating mastitis in a domestic animal in need of such a treatment, which comprises administering to the animal a pharmaceutical composition comprising a rifamycin derivative of the formula (1); wherein R is an alkyl group having 1 to 7 carbon atoms or a physiologically acceptable salt thereof as an active ingredient, and a physiologically acceptable carrier.

公开(公告)号：CA2204007A1

公开(公告)日：1997-03-13

申请号：CA2204007

申请日：1996-08-29

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  SAKASHITA SHINICHI ,  YAMANE TAKEHIKO ,  HOSOE KAZUNORI ,  FUJII KENJI

IPC: A61K31/438 ,  A61K31/536 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/535 ,  A61K31/445 ,  A61K31/54

Abstract: A remedy for digestive diseases caused by the infection with Helicobacter which comprises as the active ingredient rifamycin derivatives represented by general formula (I) or (II) or physiologically acceptable salts thereof.

公开(公告)号：DE69632677T2

公开(公告)日：2005-06-16

申请号：DE69632677

申请日：1996-08-29

Applicant: KANEKA CORP

Inventor： YAMASHITA KATSUJI ,  YAMANE TAKEHIKO ,  SAKASHITA SHINICHI ,  HOSOE KAZUNORI ,  FUJII KENJI

IPC: A61K31/438 ,  A61K31/536 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/535 ,  A61K31/54 ,  C07D498/18 ,  C07D513/18 ,  A61P31/04

Abstract: A curative medicine for a digestive organ disease caused by the infection of Helicobacter comprising as an effective component a rifamycin derivative expressed by the formula (I) or the formula (II), or a physiologically acceptable salt thereof. In the formula (I), X represents an oxygen atom or a sulfur atom, R represents an acetyl group or a hydrogen atom, R represents a hydroxy group or a hydrogen atom, R represents Äin which R and R are the same or different and each is an alkyl group having 1 to 3 carbon atoms or a group expressed by the formula (in which m represents an integer between 1 and 3)Ü, or Äin which R and R are the same or different and each is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, X represents an oxygen atom or a sulfur atom or NR äR represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or -(CH2)nX (in which n represents an integer between 1 and 4, and X represents an alkoxy group having of 1 to 3 carbon atoms, or a vinyl group or an ethynyl group, or a group expressed by the formula In the formula (II), R represents an alkyl group having 1 to 7 carbon atoms.