公开(公告)号：GB2141626A

公开(公告)日：1985-01-03

申请号：GB8410127

申请日：1984-04-18

Applicant: KAO CORP

Inventor： MOTEGI ITSURO ,  KAWAI MICHIO ,  IMOKAWA GENJI ,  NAKANURA KOICHI ,  TAKAISHI NAOTAKE

IPC: A61K8/02 ,  A61K8/37 ,  A61K8/42 ,  A61K31/165 ,  A61Q19/02 ,  A61K31/05 ,  C07C59/52 ,  C07C69/732 ,  C07C103/29 ,  C07C103/75

Abstract: A composition for application to the skin to lighten melanin pigmentation comprises a cinnamic acid derivative of the formula (I) or (II):…… … in which R' represents an acyl group having 2 to 6 carbon atoms, R1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group or an alkenyl group, and R2 represents a hydrogen atom, an alkyl group having 1 to 24 carbon atoms, a cycloalkyl group or an alkenyl group, and a dermatalogically acceptable vehicle. … The composition is locally applied to affected portions such as freckles and pigmentary deposits after sunburn to reduce the degree of pigmentation.

公开(公告)号：ES2023151B3

公开(公告)日：1992-01-01

申请号：ES87110999

申请日：1987-07-29

Applicant: KAO CORP

Inventor： HORI KIMIHIKO ,  NAKAMURA KOICHI ,  KAWAI MICHIO ,  MOTEGI ITSURO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE

IPC: A61K8/42 ,  A61K31/16 ,  A61Q17/04 ,  C07C233/12 ,  C07C233/16 ,  C07C233/67 ,  C07C233/69 ,  C07C233/81 ,  C07C233/83

公开(公告)号：FR2545355B1

公开(公告)日：1988-11-18

申请号：FR8406503

申请日：1984-04-25

Applicant: KAO CORP

Inventor： MOTEGI ITSURO ,  KAWAI MICHIO ,  IMOKAWA GENJI ,  NAKAMURA KOICHI ,  TAKAISHI NAOTAKE

IPC: A61K8/02 ,  A61K8/37 ,  A61K8/42 ,  A61K31/165 ,  A61Q19/02 ,  A61K31/22

Abstract: A melanin inhibitor comprising as the reactive component a cinnamic acid derivative of the formula (I) or (II): (I) (II) in which R' represents an acyl group having 2 to 6 carbon atoms, R1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group or an alkenyl group, and R2 represents a hydrogen atom, an alkyl group having 1 to 24 carbon atoms, a cycloalkyl group or an alkenyl group. The melanin inhibitors according to the invention are locally applied to affected portions such as of freckles and pigmentary deposits after sunburn without giving any stimulative or allergic troubles to the skin.

公开(公告)号：MX151812A

公开(公告)日：1985-03-25

申请号：MX18199680

申请日：1980-04-17

Applicant: KAO CORP

Inventor： TSUJII KAORU ,  SAITO NAOYUKI ,  KAWAI MICHIO

IPC: C11D1/08 ,  C11D3/20 ,  C11D1/00

Abstract: An alkaline builder-free detergent composition contains a partially neutralized succinic acid derivative of the formula (1): (1) wherein R is a saturated or unsaturated hydrocarbon group of 8-18 carbon atoms, and X and Y each are hydrogen, an alkali metal, ammonium or an alkanolamine, characterized in that when the composition is diluted with water thereby to give a succinic acid derivative content of 0.5 wt. %, the solution has a pH of 5.5-8.0.

公开(公告)号：DE3415413A1

公开(公告)日：1984-11-15

申请号：DE3415413

申请日：1984-04-25

Applicant: KAO CORP

Inventor： MONTEGI ITSURO ,  KAWAI MICHIO ,  IMOKAWA GENJI ,  NAKAMURA KOICHI ,  TAKAISHI NAOTAKE

IPC: A61K8/02 ,  A61K8/37 ,  A61K8/42 ,  A61K31/165 ,  A61Q19/02 ,  A61K31/215 ,  A61K7/00

Abstract: A melanin inhibitor comprising as the reactive component a cinnamic acid derivative of the formula (I) or (II): (I) (II) in which R' represents an acyl group having 2 to 6 carbon atoms, R1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group or an alkenyl group, and R2 represents a hydrogen atom, an alkyl group having 1 to 24 carbon atoms, a cycloalkyl group or an alkenyl group. The melanin inhibitors according to the invention are locally applied to affected portions such as of freckles and pigmentary deposits after sunburn without giving any stimulative or allergic troubles to the skin.

公开(公告)号：DE3884136T2

公开(公告)日：1994-04-21

申请号：DE3884136

申请日：1988-10-31

Applicant: KAO CORP

Inventor： HONMA YASUHIRO ,  MIYAZAKI NOBUO ,  MISUMI HISASHI ,  SUDA TOSHIYASU ,  AKAZAKI SHUICHI ,  MINEMATSU YOSHIHIRO ,  KAWAI MICHIO

IPC: G01N27/02 ,  A61B5/103 ,  G01N27/04 ,  A61B5/05

Abstract: This invention relates to the measurement of the moisture content retained in the skin, and enables accurate diagnosis of the skin condition by the device, which can be switched in the connection of measurement electrodes to measure the moisture content either in the surface or in the depth of the keratinous layer of the skin.

公开(公告)号：DE3884136D1

公开(公告)日：1993-10-21

申请号：DE3884136

申请日：1988-10-31

Applicant: KAO CORP

Inventor： HONMA YASUHIRO ,  MIYAZAKI NOBUO ,  MISUMI HISASHI ,  SUDA TOSHIYASU ,  AKAZAKI SHUICHI ,  MINEMATSU YOSHIHIRO ,  KAWAI MICHIO

IPC: G01N27/02 ,  A61B5/103 ,  G01N27/04 ,  A61B5/05

Abstract: This invention relates to the measurement of the moisture content retained in the skin, and enables accurate diagnosis of the skin condition by the device, which can be switched in the connection of measurement electrodes to measure the moisture content either in the surface or in the depth of the keratinous layer of the skin.

公开(公告)号：ES2045061T3

公开(公告)日：1994-01-16

申请号：ES88118083

申请日：1988-10-31

Applicant: KAO CORP

Inventor： HONMA YASUHIRO ,  MIYAZAKI NOBUO ,  MISUMI HISASHI ,  SUDA TOSHIYASU ,  AKAZAKI SHUICHI ,  MINEMATSU YOSHIHIRO ,  KAWAI MICHIO

IPC: G01N27/02 ,  A61B5/103 ,  G01N27/04 ,  A61B5/05

Abstract: This invention relates to the measurement of the moisture content retained in the skin, and enables accurate diagnosis of the skin condition by the device, which can be switched in the connection of measurement electrodes to measure the moisture content either in the surface or in the depth of the keratinous layer of the skin.

公开(公告)号：DE3770718D1

公开(公告)日：1991-07-18

申请号：DE3770718

申请日：1987-07-29

Applicant: KAO CORP

Inventor： HORI KIMIHIKO ,  NAKAMURA KOICHI ,  KAWAI MICHIO ,  MOTEGI ITSURO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE

IPC: A61K8/42 ,  A61K31/16 ,  A61Q17/04 ,  C07C233/12 ,  C07C233/16 ,  C07C233/67 ,  C07C233/69 ,  C07C233/81 ,  C07C233/83 ,  A61K7/42

Abstract: A novel melanin inhibitor comprising as an active component a p-hydroxycinnamamide derivative of the following general formula (I) in which R1 represents a hydrogen atom or a 2-hydroxyethyl group, and R2 represents a hydroxymethyl group or a carboxyl group. The melanin inhibitor may take various forms such as a lotion, an emulsion, a cream, an ointment, a gel and the like, and it is locally applied onto affected parts such as spots and freckles on the skin, and a pigmental deposition after sunburn.

公开(公告)号：AT64372T

公开(公告)日：1991-06-15

申请号：AT87110999

申请日：1987-07-29

Applicant: KAO CORP

Inventor： HORI KIMIHIKO ,  NAKAMURA KOICHI ,  KAWAI MICHIO ,  MOTEGI ITSURO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE

IPC: C07C233/16 ,  C07C233/67 ,  C07C233/81 ,  A61K7/42