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    VASODILATOR
    6.
    发明专利
    VASODILATOR 失效

    公开(公告)号：JPH0495028A

    公开(公告)日：1992-03-27

    申请号：JP21195490

    申请日：1990-08-10

    Applicant: KAO CORP

    Inventor： KOSEMURA SEIJI ,  NISHIZAWA YOSHINORI ,  KAMIYA TETSURO ,  OTSUJI KAZUYA ,  SUGIMURA YORIO

    IPC: C07D491/048 ,  A61K8/00 ,  A61K8/40 ,  A61K8/49 ,  A61K31/47 ,  A61P9/00 ,  A61P9/08 ,  A61Q5/00 ,  A61Q7/00 ,  A61Q19/10

    Abstract: PURPOSE:To obtain a vasodilator containing a dihydrofuroquinolone quaternary ammonium salt and salt thereof as active ingredients, having vasodilating action and useful to treatment and prevention of a circulatory disease. CONSTITUTION:The aimed vasodilator containing a compound expressed by the formula (R is H or OH; Me is methyl) and salt thereof as active ingredients. The compound expressed by the formula is obtained by isolation from Lunasia costulata Mig., etc., of Rutaceae according to ordinary method or obtained by chemical synthesis. The compound expressed by formula is dosed at an amount of 0.1-1000mg/adult day in the case of oral administrating agent and is preferably mixed at an amount of 0.1-10wt.% in the case of ointment, cream agent, hair-restoring agent, hair tonic and bathing agent.

    VASODILATOR COMPRISING DEPSIDONE
    7.
    发明专利
    VASODILATOR COMPRISING DEPSIDONE 失效

    公开(公告)号：JPH02223520A

    公开(公告)日：1990-09-05

    申请号：JP4330789

    申请日：1989-02-27

    Applicant: KAO CORP

    Inventor： KAMIYA TETSURO ,  OTSUJI KAZUYA ,  KOSEMURA SEIJI ,  NISHIZAWA YOSHINORI ,  SUGIMURA YORIO ,  HARA KENJI

    IPC: C07D321/10 ,  A61K31/357 ,  A61K31/365 ,  A61K36/09 ,  A61P9/08 ,  C07D493/04

    Abstract: PURPOSE:To obtain a safe and powerful vasodilator containing, as an active ingredient, a depsidone which is characteristically included in lichens. CONSTITUTION:The subject vasodilator contains, as an active ingredient, fumaric protocetraric acid which is included in Cetraria or Cladonia, and salazinic acid of formula II which is included in Parmelia. Said vasodilator has powerful vasodilating action, peripheral circulation improving action and hypotensive action, thus can be used as a hypotensor, peripheral circulation improver. In addition, when it is externally applied to skin, the blood circulation is promoted, thus it can be used as a hair tonic agent, hair growth improver and bath preparation.

    VASODILATOR
    8.
    发明专利
    VASODILATOR 失效

    公开(公告)号：JPH03163026A

    公开(公告)日：1991-07-15

    申请号：JP20889490

    申请日：1990-08-07

    Applicant: KAO CORP

    Inventor： KIKUTA SEIJI ,  AIZAWA KATSUNORI ,  KOSEMURA SEIJI ,  KAMIYA TETSURO ,  HOTTA MITSUYUKI

    IPC: A61K8/00 ,  A61K8/96 ,  A61K8/97 ,  A61K36/00 ,  A61K36/18 ,  A61K36/38 ,  A61P3/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P17/00 ,  A61Q5/00 ,  A61Q7/00 ,  A61Q19/10

    Abstract: PURPOSE:To obtain a vasodilator, containing an extract of Hypericum erectum Thunb. as an active ingredient and safely usable without any side effects. CONSTITUTION:A vasodilator obtained by drying the whole herb or any one or two or more parts of leaf, stem, root, fruit, seed and flower of Hypericum erectum Thunb., pulverizing the parts or, without drying, pulverizing the parts, then extracting the resultant parts with preferably an organic solvent (e.g. polyhydric alcohols, alcohols, hydrocarbons or ethers), providing a fraction with high activity, as necessary, according to a suitable separating means and containing the resultant fraction therein. The aforementioned extract is capable of exhibiting excellent vasodilator action and hair tonic and hair growth action, useful as the vasodilator, hair tonic and hair growth and bathing agents and effective in treating and preventing diseases such as hypertension, angina pectoris, myocardial infarction, congestive heart failure, congelation, chilblain, feeling of cold and alopecia caused by disorder in blood circulation.

    VASODILATOR
    9.
    发明专利
    VASODILATOR 失效

    公开(公告)号：JPH0495027A

    公开(公告)日：1992-03-27

    申请号：JP21195390

    申请日：1990-08-10

    Applicant: KAO CORP

    Inventor： KOSEMURA SEIJI ,  NISHIZAWA YOSHINORI ,  KAMIYA TETSURO ,  OTSUJI KAZUYA ,  SUGIMURA YORIO

    IPC: C07D491/048 ,  A61K8/00 ,  A61K8/49 ,  A61K31/47 ,  A61P9/00 ,  A61P9/08 ,  A61Q5/00 ,  A61Q7/00 ,  A61Q19/10

    Abstract: PURPOSE:To obtain a vasodilator containing a dihydrofuroquinolone derivative as an active ingredient, exhibiting safe and strong vasodilating action and useful to treatment and prevention of a circulatory disease. CONSTITUTION:The aimed vasodilator containing a compound expressed by the formula (R is H or OH; Me is methyl) as an active ingredient. The com pound obtained from Lunasia costulata Mig., etc., of Rutaceae according to ordinary method or obtained by chemical synthesis may be used as the com pound expressed by the formula. The compound expressed by formula is dosed at an amount of 0.1-1000mg/adult day in the case of oral administration and is preferably mixed at an amount of 0.1-10wt.% in the case of ointment, cream agent, hair-restoring agent, fair tonic and bathing agent.

    CRUDE DRUG EXTRACT FOR ORAL CAVITY AND COMPOSITION FOR ORAL CAVITY CONTAINING THE SAME AS ACTIVE INGREDIENT
    10.
    发明专利
    CRUDE DRUG EXTRACT FOR ORAL CAVITY AND COMPOSITION FOR ORAL CAVITY CONTAINING THE SAME AS ACTIVE INGREDIENT 失效

    公开(公告)号：JPH045222A

    公开(公告)日：1992-01-09

    申请号：JP10475390

    申请日：1990-04-20

    Applicant: KAO CORP

    Inventor： TSUJITA SATOSHI ,  INAMI NOBUKO ,  KOSEMURA SEIJI ,  NISHIZAWA YOSHINORI

    IPC: A61K8/96 ,  A61K8/97 ,  A61Q11/00

    Abstract: PURPOSE:To obtain a crude drug extract for the oral cavity useful for preventing periodontosis by extracting a crude drug selected from Psoraleae Semen, Pyrola japonica Klenze, Curcumae Rhizoma, Akebiae Caulis, Euphorbie Lathyridis Semen, Benincasae Semen and Pruni Cortex with methanol, ethanol and water. CONSTITUTION:Psoraleae Semen, Pyrola japonica Klenze, Curcumae Rhizoma, Akebiae Caulis, Euphorbie Lathyridis Semen, Benincasae Semen and Pruni Cortex are used as a crude drug and extracted with methanol and then ethanol, further water as extracting solvents at ambient temperature to 55 deg.C. The resultant extracts are then mixed and the methanol and ethanol are distilled away. The residue is subsequently fractionated with ethyl acetate and water by liquid- liquid partition. Furthermore, the obtained water fraction is extracted and fractionated with butanol and the ethyl acetate fraction is extracted and fractionated with hexane and methanol. Thereby, the objective crude drug extract is obtained. The resultant extract has selective antimicrobial activity against causative bacteria of periodontosis with low danger for microbial substitution even in prolonged administration for a long period.

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