公开(公告)号：EP2444097A4

公开(公告)日：2012-11-14

申请号：EP09846118

申请日：2009-06-15

Applicant: KAO CORP

Inventor： NAGASAWA AZUMI ,  MORIWAKI SHIGERU ,  SASAKI MITSUYOSHI ,  MATSUOKA MEGUMI ,  SASAJIMA MICHIYO ,  ITO NORIKO

IPC: A61K36/23 ,  A61K8/97 ,  A61P1/04 ,  A61P1/16 ,  A61P1/18 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P19/00 ,  A61P21/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04

CPC classification number: A61K36/232 ,  A61K8/97 ,  A61Q7/00 ,  A61Q19/00

公开(公告)号：JP2010100534A

公开(公告)日：2010-05-06

申请号：JP2008271034

申请日：2008-10-21

Applicant: Kao Corp ,  花王株式会社

Inventor： MATSUOKA MEGUMI ,  SAKAGUCHI DAISHI ,  NAGASAWA AZUMI

IPC: C07C69/78 ,  A61K8/37 ,  A61K8/97 ,  A61K31/235 ,  A61K36/00 ,  A61K36/18 ,  A61P17/14 ,  A61P43/00 ,  A61Q7/00 ,  C12N15/09 ,  C12P7/62

Abstract: PROBLEM TO BE SOLVED: To identify an active ingredient exhibiting NFAT signal-inhibiting activities and/or hair-growing activities. SOLUTION: An active ingredient that is contained in the extract from Styrax benzoin and exhibits NFAT signal-inhibiting activities and/or hair-growing activities is identified. The active ingredient is a novel neolignan derivative having a predetermined structure. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：鉴定表现出NFAT信号抑制活性和/或毛发生长活性的活性成分。 解决方案：确定了从Styrax安息香提取物中含有的活性成分，并显示NFAT信号抑制活性和/或毛发生长活性。 活性成分是具有预定结构的新型新诺维因衍生物。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2009167160A

公开(公告)日：2009-07-30

申请号：JP2008185813

申请日：2008-07-17

Applicant: Kao Corp ,  花王株式会社

Inventor： NAGASAWA AZUMI ,  MORIWAKI SHIGERU ,  SAKASAI MITSUYOSHI ,  MATSUOKA MEGUMI ,  SASAJIMA MICHIYO ,  ITO NORIKO

IPC: A61K36/23 ,  A61K8/97 ,  A61P1/16 ,  A61P3/10 ,  A61P9/10 ,  A61P11/06 ,  A61P15/00 ,  A61P17/06 ,  A61P17/14 ,  A61P21/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  A61Q7/00 ,  A61Q19/00

Abstract: PROBLEM TO BE SOLVED: To provide a novel external preparation, a hair restorer, an NFAT (nuclear factor of activated T cells) signal inhibitor, a calcineurin inhibitor, an NFAT signal inhibiting method, and a calcineurin activity inhibiting method. SOLUTION: The external preparation, the hair restorer, the NFAT signal inhibitor, and the calcineurin inhibitor comprise an extract obtained by previously washing Angelica atropurprea or the root of the plant with the use of an ethanol aqueous solution one to nine times, and thereafter extracting the ethanol washed plant or its root with the use of a 25-45 vol.% ethanol aqueous solution as an active ingredient. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供新颖的外用制剂，毛发修复剂，NFAT（活化T细胞的核因子）信号抑制剂，钙调神经磷酸酶抑制剂，NFAT信号抑制法和钙调神经磷酸酶活性抑制法。 解决方案：外用制剂，毛发恢复剂，NFAT信号抑制剂和钙调神经磷酸酶抑制剂包含通过使用乙醇水溶液预先洗涤当归阿托普兰或植物根而获得的提取物一至九次， 然后用25-45体积％的乙醇水溶液作为活性成分萃取乙醇洗涤的植物或其根部。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2013216637A

公开(公告)日：2013-10-24

申请号：JP2012090480

申请日：2012-04-11

Applicant: Kao Corp ,  花王株式会社

Inventor： MATSUOKA MEGUMI ,  INABA SAYAKA

IPC: A61K8/97 ,  A61K8/33 ,  A61K8/44 ,  A61K8/49 ,  A61Q5/02 ,  A61Q19/00 ,  A61Q19/10

Abstract: PROBLEM TO BE SOLVED: To reduce irritation to skin and to improve antiseptic properties.SOLUTION: A skin external preparation includes: an extract of Phaeophyta, Laminaria digitata and the like; phenoxyethanol; and one or more water soluble ingredients selected from aspartic acid, glycylglycine, salts of them, acetyl hydroxyproline, succinic acid 2-(2-hydroxyethoxy)ethyl guanidine and nicotinamide.

Abstract translation: 要解决的问题：减少对皮肤的刺激和改善防腐性能。解决方案：皮肤外用制剂包括：Phaeophyta，Laminaria digitata等的提取物; 苯氧乙醇 和一种或多种选自天冬氨酸，甘氨酰甘氨酸，它们的盐，乙酰羟脯氨酸，琥珀酸2-（2-羟基乙氧基）乙基胍和烟酰胺的水溶性成分。