公开(公告)号：JP2012140405A

公开(公告)日：2012-07-26

申请号：JP2011256362

申请日：2011-11-24

Applicant: Kao Corp ,  花王株式会社

Inventor： OBA TAKASHI ,  MURASE DAIKI

IPC: A61K36/09 ,  A61K8/368 ,  A61K8/97 ,  A61K31/216 ,  A61P43/00 ,  A61Q19/02

Abstract: PROBLEM TO BE SOLVED: To provide a production method of a Beomycesic acid-rich Thamnolia vermicularis extract and a skin whitening agent.SOLUTION: The production method of the Beomycesic acid-rich Thamnolia vermicularis extract includes a step of extracting Thamnolia vermicularis, using an alcohol solution containing 60 v/v% or more of alcohol, cyclic ethers and ethers having 2 or more oxygen atoms, and at least one solution selected from the group consisting of esters with a total carbon number of 3-6. An inhibitor of the activity of endothelin and the skin whitening agent containing the extract as an active ingredient are also provided.

Abstract translation: 待解决的问题：提供富含肉碱酸的Thamnolia蠕虫提取物和皮肤增白剂的制备方法。 解决方案：富含肉碱酸的Thamnolia蠕虫提取物的制备方法包括使用含有60v / v％以上的醇，环醚和具有2个或更多个氧原子的醚的醇溶液萃取Thamnolia vermicularis的步骤 ，以及选自总碳数为3-6的酯的至少一种溶液。 还提供了含有提取物作为活性成分的内皮素和皮肤增白剂的活性抑制剂。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2005112818A

公开(公告)日：2005-04-28

申请号：JP2003351979

申请日：2003-10-10

Applicant: Kao Corp ,  花王株式会社

Inventor： OBA TAKASHI

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/41 ,  A61K31/138 ,  A61P17/16 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/02 ,  C07C213/02 ,  C07C217/34 ,  C07C217/36 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To provide the chemically stable compounds having good water solubility and excellent tyrosinase inhibiting activity, and to provide a whitening agent using the same.
SOLUTION: The compounds are substituted phenoxypropanolamines represented by general formula (1) (wherein X
1 is hydroxy or carboxy; R
1 is a 2-12C alkyl which may be substituted for H or one to three hydroxy groups; and R
2 is a 2-12C alkyl which may be substituted for one to three hydroxy groups) or their salts.
COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供具有良好的水溶性和优异的酪氨酸酶抑制活性的化学稳定的化合物，并提供使用其的增白剂。 解决方案：化合物是由通式（1）表示的取代的苯氧基丙醇胺（其中X 1 是羟基或羧基; R“SP”是2-12C烷基，其可以 取代H或一至三个羟基; R SP 2是可被取代一至三个羟基的2-12C烷基）或其盐。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2003160479A

公开(公告)日：2003-06-03

申请号：JP2002261463

申请日：2002-09-06

Applicant: KAO CORP

Inventor： OBA TAKASHI ,  SOGA HAJIME

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/36 ,  A61K31/09 ,  A61K31/192 ,  A61P9/00 ,  A61P17/00 ,  A61P17/14 ,  A61P17/16 ,  A61Q5/00 ,  A61Q7/00 ,  A61Q19/00 ,  A61K7/00 ,  A61K7/06 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a blood circulation promoter, a hair grower and an external preparation composition which keep excellent promotion effect on blood circulation for many hours, high hair growth effect, no feeling of skin irritation and is safely usable as a medicine or a cosmetic. SOLUTION: This external preparation composition contains a hydroquinone derivative represented by general formula (1) [R 1 is a 2-4C alkylene group; R 2 is a 2-24C hydrocarbon group; A is represented by formula (a) (R 3 is a hydrogen atom or a 1-6C hydrocarbon group; X is a hydrogen atom or a hydroxy group; m is an integer of 0-4) or formula (b) -COOH; n is an integer of 0-3] or its salt. COPYRIGHT: (C)2003,JPO

公开(公告)号：JP2013253060A

公开(公告)日：2013-12-19

申请号：JP2012130799

申请日：2012-06-08

Applicant: KAO CORP

Inventor： OBA TAKASHI ,  KIKUCHI MAMIKO

IPC: A61K36/09 ,  A61K8/97 ,  A61K36/00 ,  A61P17/00 ,  A61P43/00 ,  A61Q19/02

Abstract: PROBLEM TO BE SOLVED: To provide a process for producing an extract from a lichen belonging to the genus Usnea which can be suitably used for skin external agents such as whitening agents.SOLUTION: A process for producing an extract from a lichen belonging to the genus Usnea which has a low usnic acid content, includes extracting a lichen belonging to the genus Usnea with an aqueous alcohol solution having an alcohol content of >70% by volume, and applying at least one treatment selected from the group consisting of a low temperature preserving treatment and a hydration treatment to the obtained extract, in which a remaining ratio of the usnic acid after subjected to the treatment is

公开(公告)号：JP2011178751A

公开(公告)日：2011-09-15

申请号：JP2010046795

申请日：2010-03-03

Applicant: Kao Corp ,  花王株式会社

Inventor： OBA TAKASHI ,  AMANO KYOKO

IPC: A61K8/97 ,  A61K36/28 ,  A61P17/00 ,  A61P43/00 ,  A61Q19/02

Abstract: PROBLEM TO BE SOLVED: To provide a highly safe whitening agent, melanogenesis inhibitor and dopa oxidase activity inhibitor. SOLUTION: The whitening agent, melanogenesis inhibitor and dopa oxidase activity inhibitor, include organic solvent extracts of Lactuca virosa (Lactuca sativa) belonging to a plant of genus Lactuca, family Asteraceae. Where, a hydrophilic organic solvent is suitably used for the extraction. The whitening agent exhibits highly safe whitening effects even when using for a long time, by having excellent dopa oxidase activity-inhibiting properties together with low cytotoxicity. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：提供高度安全的增白剂，黑素生成抑制剂和多巴氧化酶活性抑制剂。 解决方案：美白剂，黑素生成抑制剂和多巴氧化酶活性抑制剂包括属于莴苣属植物的菊科植物莴苣（Lactuca sativa）的有机溶剂提取物。 其中亲水性有机溶剂适合用于萃取。 即使长时间使用，通过具有优异的多巴氧化酶活性抑制性质以及低细胞毒性，美白剂也显示出高度安全的美白效果。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2006282645A

公开(公告)日：2006-10-19

申请号：JP2005108755

申请日：2005-04-05

Applicant: Kao Corp ,  花王株式会社

Inventor： OBA TAKASHI

IPC: A61K8/00 ,  A61Q19/00 ,  A61Q19/02 ,  C07C217/34 ,  C07C217/36 ,  C07D207/06

Abstract: PROBLEM TO BE SOLVED: To obtain a chemically stabler compound having excellent tyrosinase inhibition activity and provide a bleaching agent and a skin preparation for external use containing the same.
SOLUTION: The bleaching agent contains a substituted phenoxypropanolamine or its salt expressed by general formula (1), wherein X
1 expresses hydroxy or carboxy; R
1 and R
2 may be the same or different and express H, a 1-18C alkyl or a 2-18C alkyl substituted with a 1-8C alkoxy or a 2-8C hydroxyalkoxy, or form a cyclic amino group (wherein the hydrogen atom on a carbon atom constituting the cyclic amino group may be substituted with methyl, OH, a 1-8C alkoxy, hydroxyalkyl or a 2-8C hydroxyalkoxy).
COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 待解决的问题：获得具有优异的酪氨酸酶抑制活性的化学稳定化合物，并提供漂白剂和含有该漂白剂和外用皮肤制剂。 解决方案：漂白剂含有由通式（1）表示的取代的苯氧基丙胺胺或其盐，其中X 1表示羟基或羧基; R 1 和R 2可以相同或不同，表示H，1-18C烷基或被1-8C烷氧基取代的2-18C烷基或2 -8C羟基烷氧基，或形成环状氨基（其中构成环状氨基的碳原子上的氢原子可以被甲基，OH，1-8C烷氧基，羟基烷基或2-8C羟基烷氧基取代）。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2001031550A

公开(公告)日：2001-02-06

申请号：JP20039699

申请日：1999-07-14

Applicant: KAO CORP

Inventor： OBA TAKASHI ,  SOGA HAJIME ,  YAMAMURO AKIRA ,  KITAHARA KO ,  KAIZU KAZUHIRO

IPC: A61K8/00 ,  A61K8/30 ,  A61K8/39 ,  A61K31/00 ,  A61K31/09 ,  A61P9/00 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain a blood circulation-promoting agent which exhibits a blood circulation-promoting action, gives a persistent warm-sensitive effect to skin, scarcely gives an unpleasant skin-irritating touch to a human body, and is useful for medicines or cosmetics, by including a specific veratryl ether derivative. SOLUTION: This blood circulation-promoting agent contains a veratryl ether derivative of the formula [R1 is a 1 to 18C alkyl or a 7 to 24C aralkyl; (m) is 0 to 2] as an active ingredient. The content of the compound of the formula is preferably 0.001 to 10 wt.%. One or more compounds among the compounds of the formula may be used for the blood circulation-promoting agent. One or more other compounds giving warm-sensitive touches or one or more plant extracts having blood circulation-promoting effects, such as the powder of red pepper, may together be used to further improve the heat-sensitive effect without strengthening a skin-irritating touch. The compound of the formula can be obtained by reacting veratryl alcohol with an alcohol in the presence of a strong acid as a dehydrating agent.

公开(公告)号：JPH11209320A

公开(公告)日：1999-08-03

申请号：JP1434898

申请日：1998-01-27

Applicant: KAO CORP

Inventor： ONO TOSHIYA ,  OBA TAKASHI ,  YAMAGUCHI MASAKAZU ,  YAMAMURO AKIRA ,  FUJIKURA YOSHIAKI

IPC: A61K8/30 ,  A61K8/34 ,  A61K31/09 ,  A61P17/00 ,  C07C43/205 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain the subject new compound having a specific (substituted) alkyl substituent, providing a reduced undesirable side effect and skin irritation, capable of rapidly imparting an effect of a strong warm feeling to skin when using the compound, capable of sustaining the feeling for a long period and useful as a skin preparation for external use. SOLUTION: This new compound is the ore of the formula [R is a 3-6C (branched) alkyl], e.g. veratryl n-butyl ether. The compound of the formula is obtained by reacting 3,4-dimethoxybenzyl halide with a corresponding alkoxide in a solvent or without the solvent. The compound is preferably used as a skin preparation for external use in a dosage form such as a lotion, an emulsion, a skin lotion, a dentifrice, a soap, a cataplasm and a cream regulated so as to include 0.001-10 wt.%, preferably 0.01-5 wt.% compound of the formula.

公开(公告)号：JP2013227230A

公开(公告)日：2013-11-07

申请号：JP2012098659

申请日：2012-04-24

Applicant: Kao Corp ,  花王株式会社

Inventor： OBA TAKASHI ,  KIKUCHI MAMIKO ,  YATANI TERU

IPC: A61K8/34 ,  A61Q19/02

CPC classification number: A61K31/05 ,  A61K8/347 ,  A61K2800/782 ,  A61Q19/02

Abstract: PROBLEM TO BE SOLVED: To provide a highly-safe tyrosinase activity inhibitor having excellent tyrosinase activity inhibitory action, a melanin production inhibitor, a whitening agent and a cosmetic.SOLUTION: A tyrosinase inhibitor containing isopropylmethylphenol as an active ingredient, a melanin production inhibitor, a whitening agent, and a cosmetic containing isopropylmethylphenol with the concentration of 0.00001-0.04 w/v% are provided. Overproduction of melanin on the skin can be controlled, and pigmentation after being sunburned or skin blemish/freckle can be prevented or improved.

Abstract translation: 要解决的问题：提供具有优异的酪氨酸酶活性抑制作用的高度安全的酪氨酸酶活性抑制剂，黑色素产生抑制剂，增白剂和化妆品。解决方案：含有异丙基甲基苯酚作为活性成分的酪氨酸酶抑制剂，黑色素产生抑制剂， 美白剂和含有浓度为0.00001-0.04w / v％的异丙基甲基苯酚的化妆品。 可以控制皮肤上黑色素的过度产生，可以防止或改善晒伤后的色素沉着或皮肤瑕疵/雀斑。

公开(公告)号：JP2013166731A

公开(公告)日：2013-08-29

申请号：JP2012032039

申请日：2012-02-16

Applicant: Kao Corp ,  花王株式会社

Inventor： OBA TAKASHI ,  MURASE DAIKI ,  KIKUCHI MAMIKO

IPC: A61K8/36 ,  A61K8/37 ,  A61Q19/02

Abstract: PROBLEM TO BE SOLVED: To provide a new endothelin activity inhibitor.SOLUTION: An endothelin activity inhibitor is a compound expressed by general formula (1) [wherein, Rto Rare each H or alkyl: and Ris H or a group expressed by general formula (2)] or its salt.

Abstract translation: 要解决的问题：提供新的内皮素活性抑制剂。解决方案：内皮素活性抑制剂是由通式（1）表示的化合物[其中，Rto每个H或烷基：和Ris H或由通式（ 2）]或其盐。