公开(公告)号：DE19527313A1

公开(公告)日：1996-02-01

申请号：DE19527313

申请日：1995-07-26

Applicant: KAO CORP

Inventor： NAGAI MINORU ,  KAWADA HIROMITSU ,  TSUCHIYA MAYUMI ,  YAMASAKI SEIJI ,  YAMAMURO AKIRA ,  ONO TOSHIYA

IPC: A61K8/02 ,  A61K8/43 ,  A61K8/49 ,  A61K8/73 ,  A61Q19/00 ,  C07C279/08 ,  C07D207/16 ,  C07F9/09 ,  A61K7/48 ,  C07C279/14

Abstract: Guanidine derivs have formulae (I), (II) and (III). Acid addn. salts are included. A, B = 2-8C alkylene; D = single bond, -CO- or opt. substd 1-6C alkylene; E = H, lower alkyl, aralkyl or opt. substd. aryl; m = 1-6; n = 0-6; R = H, lower alkyl or -(AO)m-(BO)n-D-E; -(AO)m-(BO)n-D-E = hydroxyethyl if R = Me; l = 1-10; G = H, OH, COOH, SO3H or a phosphoric acid gp; one of R , R and R is OH and the others are H.

公开(公告)号：DE69013377T2

公开(公告)日：1995-04-27

申请号：DE69013377

申请日：1990-03-19

Applicant: KAO CORP

Inventor： SAWADA HIROKI ,  NAGUMO HIROSHI ,  KOIKE TOYOMI ,  KIMURA AKIO ,  YAMAMURO AKIRA

IPC: C07H1/06 ,  C07H15/04

Abstract: A process is disclosed for the production of an alkyl glycoside stable in hue and odor, which comprises the steps of (1) reacting a sugar with alcohol to obtain an alkyl glycoside reaction product containing a higher alcohol, (2) decoloring the alkyl glycoside reaction product with hydrogen peroxide, (3) contacting the decolored alkyl glycoside with a metal/hydrogen complex represented by formula (I) M(BH4)z (I) wherein M is an alkali metal, Ca, Zn or (CH3)4N; and z is 1 when M is an alkali metal or (CH3)4N and z is 2 when M is Ca or Zn; to substantially eliminate residual hydrogen peroxide, and then (4) decomposing the remaining metal/hydrogen complex with an acid.

公开(公告)号：DE69006059D1

公开(公告)日：1994-03-03

申请号：DE69006059

申请日：1990-03-19

Applicant: KAO CORP

Inventor： YAMAMURO AKIRA ,  AMAU MAKOTO ,  FUJITA TAKAAKI ,  AIMONO KIYOSHI ,  KIMURA AKIO

IPC: C07H15/04

Abstract: A process is disclosed for the production of an alkyl glycoside excellent in hue, which comprises (1) reacting a sugar with alcohol to obtain an alkyl glycoside reaction product containing an unreacted higher alcohol, (2) reacting the resulting product with a metal/hydrogen complex represented by formula (I) M(BH4)x (I) wherein M is an alkali metal, Ca, Zn, or (CH3)4N; and x is 1 when M is an alkali metal or (CH3)4N and x is 2 when M is Ca or Zn; (3) separating the resulting reaction mixture into the alkyl glycoside and the unreacted higher alcohol, and (4) decomposing the remaining metal/hydrogen complex with an acid.

公开(公告)号：EP0965327A4

公开(公告)日：2001-08-29

申请号：EP97943153

申请日：1997-10-08

Applicant: KAO CORP

Inventor： FUJIMURA TSUTOMU ,  ITO NORIKO ,  NAGAI MINORU ,  ONO TOSHIYA ,  YAMAMURO AKIRA ,  TAKEMA YOSHINORI

IPC: A01N43/00 ,  A01N43/36 ,  A01N43/40 ,  A01N43/58 ,  A01N43/64 ,  A61K6/00 ,  A61K8/49 ,  A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/535 ,  A61P17/00 ,  A61Q19/08 ,  A61K7/48 ,  A61K7/00

CPC classification number: A61Q19/08 ,  A61K8/49 ,  A61K8/4913 ,  A61K8/4926 ,  A61K8/494

Abstract: Wrinkling modifiers and anti-aging cosmetic preparations which contain guanidine derivatives of general formula (1) or salts thereof, wherein (a) is a group derived from a heterocyclic compound selected from among azetidine, pyrrolidine, piperidine, piperazine and morpholine; and R and R are each independently hydrogen, alkyl, hydroxyl, hydroxyalkyl, carboxyl, carboxyalkyl or amidino. The cosmetic preparations are excellent in the effect of suppressing wrinkling and the effect of making wrinkles disappear and exhibit an excellent feeling in use.

公开(公告)号：DE69214346T2

公开(公告)日：1997-03-06

申请号：DE69214346

申请日：1992-05-15

Applicant: KAO CORP

Inventor： KOIKE TOYOMI ,  NAGUMO HIROSHI ,  YAMAMURO AKIRA ,  YOKOTA YUKINAGA

IPC: C07H15/04

Abstract: Alkyl glycoside aqueous solutions, which satisfy the following conditions (a) and/or (b): (a) the solution is maintained at a pH value exceeding 7, and (b) the solution contains a water-soluble alcohol, are highly stable with respect to microbial activities, such as putrefaction and fungal growth, and are useful as surface active agents. y

公开(公告)号：DE69214346D1

公开(公告)日：1996-11-14

申请号：DE69214346

申请日：1992-05-15

Applicant: KAO CORP

Inventor： KOIKE TOYOMI ,  NAGUMO HIROSHI ,  YAMAMURO AKIRA ,  YOKOTA YUKINAGA

IPC: C07H15/04

Abstract: Alkyl glycoside aqueous solutions, which satisfy the following conditions (a) and/or (b): (a) the solution is maintained at a pH value exceeding 7, and (b) the solution contains a water-soluble alcohol, are highly stable with respect to microbial activities, such as putrefaction and fungal growth, and are useful as surface active agents. y

公开(公告)号：DE69006059T2

公开(公告)日：1994-06-30

申请号：DE69006059

申请日：1990-03-19

Applicant: KAO CORP

Inventor： YAMAMURO AKIRA ,  AMAU MAKOTO ,  FUJITA TAKAAKI ,  AIMONO KIYOSHI ,  KIMURA AKIO

IPC: C07H15/04

Abstract: A process is disclosed for the production of an alkyl glycoside excellent in hue, which comprises (1) reacting a sugar with alcohol to obtain an alkyl glycoside reaction product containing an unreacted higher alcohol, (2) reacting the resulting product with a metal/hydrogen complex represented by formula (I) M(BH4)x (I) wherein M is an alkali metal, Ca, Zn, or (CH3)4N; and x is 1 when M is an alkali metal or (CH3)4N and x is 2 when M is Ca or Zn; (3) separating the resulting reaction mixture into the alkyl glycoside and the unreacted higher alcohol, and (4) decomposing the remaining metal/hydrogen complex with an acid.

公开(公告)号：DE69022264T2

公开(公告)日：1996-04-04

申请号：DE69022264

申请日：1990-03-19

Applicant: KAO CORP

Inventor： YAMAMURO AKIRA ,  KOIKE TOYOMI ,  SAWADA HIROKI ,  KIMURA AKIO

IPC: C07H1/00 ,  C07C29/80 ,  C07C29/88 ,  C07H15/04

Abstract: A process is described for the production of an alkyl glycoside which comprises distilling a higher alcohol in the presence of an alkaline substance, or washing a higher alcohol with an aqueous solution of an alkaline substance, and then reacting the higher alcohol with a sugar or a reaction product of a sugar and a lower alcohol. According to this process, an alkyl glycoside showing an excellent hue can be produced by repeatedly using unreacted alcohol recovered from the reaction mixture in the production of an alkyl glycoside.

公开(公告)号：ES2079388T3

公开(公告)日：1996-01-16

申请号：ES90105154

申请日：1990-03-19

Applicant: KAO CORP

Inventor： YAMAMURO AKIRA ,  KOIKE TOYOMI ,  SAWADA HIROKI ,  KIMURA AKIO

IPC: C07H1/00 ,  C07C29/80 ,  C07C29/88 ,  C07H15/04

Abstract: A process is described for the production of an alkyl glycoside which comprises distilling a higher alcohol in the presence of an alkaline substance, or washing a higher alcohol with an aqueous solution of an alkaline substance, and then reacting the higher alcohol with a sugar or a reaction product of a sugar and a lower alcohol. According to this process, an alkyl glycoside showing an excellent hue can be produced by repeatedly using unreacted alcohol recovered from the reaction mixture in the production of an alkyl glycoside.

公开(公告)号：DE69022264D1

公开(公告)日：1995-10-19

申请号：DE69022264

申请日：1990-03-19

Applicant: KAO CORP

Inventor： YAMAMURO AKIRA ,  KOIKE TOYOMI ,  SAWADA HIROKI ,  KIMURA AKIO

IPC: C07H1/00 ,  C07C29/80 ,  C07C29/88 ,  C07H15/04

Abstract: A process is described for the production of an alkyl glycoside which comprises distilling a higher alcohol in the presence of an alkaline substance, or washing a higher alcohol with an aqueous solution of an alkaline substance, and then reacting the higher alcohol with a sugar or a reaction product of a sugar and a lower alcohol. According to this process, an alkyl glycoside showing an excellent hue can be produced by repeatedly using unreacted alcohol recovered from the reaction mixture in the production of an alkyl glycoside.