公开(公告)号：DE19527313A1

公开(公告)日：1996-02-01

申请号：DE19527313

申请日：1995-07-26

Applicant: KAO CORP

Inventor： NAGAI MINORU ,  KAWADA HIROMITSU ,  TSUCHIYA MAYUMI ,  YAMASAKI SEIJI ,  YAMAMURO AKIRA ,  ONO TOSHIYA

IPC: A61K8/02 ,  A61K8/43 ,  A61K8/49 ,  A61K8/73 ,  A61Q19/00 ,  C07C279/08 ,  C07D207/16 ,  C07F9/09 ,  A61K7/48 ,  C07C279/14

Abstract: Guanidine derivs have formulae (I), (II) and (III). Acid addn. salts are included. A, B = 2-8C alkylene; D = single bond, -CO- or opt. substd 1-6C alkylene; E = H, lower alkyl, aralkyl or opt. substd. aryl; m = 1-6; n = 0-6; R = H, lower alkyl or -(AO)m-(BO)n-D-E; -(AO)m-(BO)n-D-E = hydroxyethyl if R = Me; l = 1-10; G = H, OH, COOH, SO3H or a phosphoric acid gp; one of R , R and R is OH and the others are H.

公开(公告)号：DE60135271D1

公开(公告)日：2008-09-25

申请号：DE60135271

申请日：2001-01-19

Applicant: KAO CORP

Inventor： AOSHIMA MASAYOSHI ,  ONO TOSHIYA ,  TOMOKUNI ATSUSHI ,  TSUDA HIROKO

IPC: A61K8/02 ,  A61K8/73 ,  A61K8/88 ,  A61Q19/10 ,  C11D1/02 ,  C11D1/66 ,  C11D1/88 ,  C11D3/14 ,  C11D3/22 ,  C11D3/37 ,  C11D3/384 ,  C11D17/00

公开(公告)号：EP1163895A4

公开(公告)日：2006-04-19

申请号：EP01901458

申请日：2001-01-19

Applicant: KAO CORP

Inventor： AOSHIMA MASAYOSHI ,  ONO TOSHIYA ,  TOMOKUNI ATSUSHI ,  TSUDA HIROKO

IPC: A61K8/02 ,  A61K8/73 ,  A61K8/88 ,  A61Q19/10 ,  C11D1/02 ,  C11D1/66 ,  C11D1/88 ,  C11D3/14 ,  C11D3/22 ,  C11D3/37 ,  C11D3/384 ,  C11D17/00 ,  A61K7/02 ,  A61K7/50

CPC classification number: A61K8/027 ,  A61K8/02 ,  A61K8/731 ,  A61K8/88 ,  A61Q19/10 ,  C11D1/02 ,  C11D1/66 ,  C11D1/88 ,  C11D3/14 ,  C11D3/222 ,  C11D3/225 ,  C11D3/226 ,  C11D3/37 ,  C11D3/3715 ,  C11D3/3719 ,  C11D3/3769 ,  C11D3/384 ,  C11D17/0004

Abstract: Detergent compositions containing the following components (A) and (B): (A) 3 to 60% by weight of one or more surfactants selected from among anionic surfactants, ampholytic surfactants and hydrophilic nonionic surfactants; and (B) 0.1 to 50% by weight of fibers having an average fiver length of 0.02 to 1 mm. These detergent compositions exhibit a favorable effect of removing stains and excellent massage and rinsing properties.

Abstract translation: （A）和（B）的洗涤剂组合物：（A）3-60重量％的选自阴离子表面活性剂，两性表面活性剂和亲水性非离子表面活性剂的一种或多种表面活性剂; 和（B）0.1至50重量％的平均长度为0.02至1mm的纤维。 这些洗涤剂组合物表现出去除污渍的良好效果和优异的按摩和漂洗性能。

公开(公告)号：EP0965327A4

公开(公告)日：2001-08-29

申请号：EP97943153

申请日：1997-10-08

Applicant: KAO CORP

Inventor： FUJIMURA TSUTOMU ,  ITO NORIKO ,  NAGAI MINORU ,  ONO TOSHIYA ,  YAMAMURO AKIRA ,  TAKEMA YOSHINORI

IPC: A01N43/00 ,  A01N43/36 ,  A01N43/40 ,  A01N43/58 ,  A01N43/64 ,  A61K6/00 ,  A61K8/49 ,  A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/535 ,  A61P17/00 ,  A61Q19/08 ,  A61K7/48 ,  A61K7/00

CPC classification number: A61Q19/08 ,  A61K8/49 ,  A61K8/4913 ,  A61K8/4926 ,  A61K8/494

Abstract: Wrinkling modifiers and anti-aging cosmetic preparations which contain guanidine derivatives of general formula (1) or salts thereof, wherein (a) is a group derived from a heterocyclic compound selected from among azetidine, pyrrolidine, piperidine, piperazine and morpholine; and R and R are each independently hydrogen, alkyl, hydroxyl, hydroxyalkyl, carboxyl, carboxyalkyl or amidino. The cosmetic preparations are excellent in the effect of suppressing wrinkling and the effect of making wrinkles disappear and exhibit an excellent feeling in use.

公开(公告)号：DE19527313B4

公开(公告)日：2012-01-26

申请号：DE19527313

申请日：1995-07-26

Applicant: KAO CORP

Inventor： NAGAI MINORU ,  KAWADA HIROMITSU ,  TSUCHIYA MAYUMI ,  YAMASAKI SEIJI ,  YAMAMURO AKIRA ,  ONO TOSHIYA

IPC: A61K8/43 ,  A61K8/02 ,  A61K8/34 ,  A61K8/36 ,  A61K8/37 ,  A61K8/46 ,  A61K8/49 ,  A61K8/73 ,  A61Q19/00 ,  C07C279/08 ,  C07D207/16 ,  C07F9/09

Abstract: Verwendung eines Guanidinderivates, das durch die Formeln (1), (2) oder (3) dargestellt ist, oder eines Säureadditionssalz davon als Hautkosmetikum zum Weichmachen der Keratinschichtworin in Formel (1): A und B gleich oder voneinander verschieden sein können und jeweils eine Alkylengruppe mit 2 bis 8 Kohlenstoffatomen darstellen; D eine Einfachbindung, -CO- oder eine Alkylengruppe, die 1 bis 6 Kohlenstoffatome hat und die eine Substituentengruppe haben kann, darstellt; E ein Wasserstoffatom, eine Niedrigalkylgruppe, eine Aralkylgruppe oder eine Arylgruppe, die eine Substituentengruppe haben kann, darstellt; m eine ganze Zahl von 1 bis 6 ist; n eine ganze Zahl von 1 bis 6 ist; und R1 ein Wasserstoffatom, eine Niedrigalkylgruppe oder -(AO)m-(BO)n-D-E darstellt, unter der Voraussetzung, dass -(AO)m-(BO)n-D-E keine Hydroxyethylgruppe ist, wenn R1 eine Methylgruppe ist; in Formel (2): l eine ppe, Carboxylgruppe oder eine Phosphorsäuregruppe ist; und R1 wie oben definiert ist;...

公开(公告)号：DE69732796D1

公开(公告)日：2005-04-21

申请号：DE69732796

申请日：1997-10-08

Applicant: KAO CORP

Inventor： FUJIMURA TSUTOMU ,  ITO NORIKO ,  NAGAI MINORU ,  ONO TOSHIYA ,  YAMAMURO AKIRA ,  TAKEMA YOSHINORI

IPC: A01N43/00 ,  A01N43/36 ,  A01N43/40 ,  A01N43/58 ,  A01N43/64 ,  A61K6/00 ,  A61K8/49 ,  A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/535 ,  A61P17/00 ,  A61Q19/08 ,  A61K7/48 ,  A61K7/00

Abstract: Wrinkling modifiers and anti-aging cosmetic preparations which contain guanidine derivatives of general formula (1) or salts thereof, wherein (a) is a group derived from a heterocyclic compound selected from among azetidine, pyrrolidine, piperidine, piperazine and morpholine; and R and R are each independently hydrogen, alkyl, hydroxyl, hydroxyalkyl, carboxyl, carboxyalkyl or amidino. The cosmetic preparations are excellent in the effect of suppressing wrinkling and the effect of making wrinkles disappear and exhibit an excellent feeling in use

公开(公告)号：DE69732796T2

公开(公告)日：2006-05-04

申请号：DE69732796

申请日：1997-10-08

Applicant: KAO CORP

Inventor： FUJIMURA TSUTOMU ,  ITO NORIKO ,  NAGAI MINORU ,  ONO TOSHIYA ,  YAMAMURO AKIRA ,  TAKEMA YOSHINORI

IPC: A01N43/00 ,  A01N43/36 ,  A01N43/40 ,  A01N43/58 ,  A01N43/64 ,  A61K6/00 ,  A61K8/49 ,  A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/535 ,  A61P17/00 ,  A61Q19/08

Abstract: Wrinkling modifiers and anti-aging cosmetic preparations which contain guanidine derivatives of general formula (1) or salts thereof, wherein (a) is a group derived from a heterocyclic compound selected from among azetidine, pyrrolidine, piperidine, piperazine and morpholine; and R and R are each independently hydrogen, alkyl, hydroxyl, hydroxyalkyl, carboxyl, carboxyalkyl or amidino. The cosmetic preparations are excellent in the effect of suppressing wrinkling and the effect of making wrinkles disappear and exhibit an excellent feeling in use

公开(公告)号：ID30487A

公开(公告)日：2001-12-13

申请号：ID20012017

申请日：2001-01-19

Applicant: KAO CORP

Inventor： AOSHIMA MASAYOSHI ,  ONO TOSHIYA ,  TOMOKUNI ATSUSHI ,  TSUDA HIROKO

IPC: A61K8/02 ,  A61K8/73 ,  A61K8/88 ,  A61Q19/10 ,  C11D1/02 ,  C11D1/66 ,  C11D1/88 ,  C11D3/14 ,  C11D3/22 ,  C11D3/37 ,  C11D3/384 ,  C11D17/00 ,  A61K7/02 ,  A61K7/50

公开(公告)号：JPH1017442A

公开(公告)日：1998-01-20

申请号：JP17477496

申请日：1996-07-04

Applicant: KAO CORP

Inventor： KAJINO TAKAYOSHI ,  NAGAI MINORU ,  ONO TOSHIYA ,  TABATA YOSHIKO ,  HIRANO REI

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/43 ,  A61Q5/00 ,  A61Q5/04 ,  A61K7/09 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain a composition capable of permanently straightening curly or twisted hair by nature without damaging the normal air, containing a keratin- reducing substance and a guanidine derivative as active ingredients. SOLUTION: This hair treatment agent composition contains, as active ingredients, 1-20wt.% of a keratin-reducing substance (e.g. thioglycolic acid) and 0.1-30wt.% of a guanidine derivative of the formula (X and Y are each H, an alkyl, alkenyl, aromatic ring, aralkyl, etc.; Z and Z are each H, an alkyl, alkenyl, aromatic ring, aralkyl, guanidino, etc.) (e.g. butylguanidine) or an acidadded salt thereof, of pref. formulated with 0.5-50wt.% of an organic solvent (e.g. n-propanol). The composition, which is adjusted to pH3-9, can be prepared by a conventional means into an one-pack or two-pack type curly hair corrective, straight perming agent, permanent wave agent, sustainable hair setting agent, sustainable hair flexibilizer, etc.

公开(公告)号：JPH11209321A

公开(公告)日：1999-08-03

申请号：JP1435098

申请日：1998-01-27

Applicant: KAO CORP

Inventor： ONO TOSHIYA ,  OBA TAKASHI ,  YAMAGUCHI MASAKAZU ,  YAMAMURO AKIRA ,  FUJIKURA YOSHIAKI

IPC: A61K8/30 ,  A61K8/34 ,  A61K31/085 ,  A61P17/00 ,  C07C43/23 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain the subject new compound having a specific (substituted) alkyl substituent, providing a reduced undesirable side effect and skin irritation, capable of rapidly imparting an effect of a strong warm feeling to skin when using the compound, capable of sustaining the feeling for a long period and useful as a skin preparation for external use. SOLUTION: This new compound is the one of the formula [R is a 4-6C (branched) alkyl], e.g. ethylvanillyl n-butyl ether. The compound of the formula is obtained by reacting 3-ethoxy-4-hydroxybenzyl halide with a corresponding alkoxide in a solvent or without the solvent. The compound is preferably used as a skin preparation for external use in a dosage form such as a lotion, an emulsion, a skin lotion, a dentifrice, a soap, a cataplasma and a cream regulated so as to include 0.001-10 wt.%, preferably 0.01-5 wt.% compound of the formula.