公开(公告)号：ES2077948T3

公开(公告)日：1995-12-01

申请号：ES92115766

申请日：1988-03-02

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKAZAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE ,  OHTOMO TSUYOSHI ,  KOMORI TAKASHI

IPC: A61K8/42 ,  A61K8/68 ,  A61Q5/00 ,  A61Q19/00 ,  C07H15/04 ,  A61K7/48

Abstract: An external skin care preparation comprising a compound represented by the following general formula (II), or a salt thereof: General formula (II): wherein R6 and R7 mean individually an aliphatic hydrocarbon group having 10-26 carbon atoms and R8 denotes a group -CH CH OH, -CH COOH or -COCH , and further comprising a surfactant.p

公开(公告)号：DE3884021T2

公开(公告)日：1994-04-14

申请号：DE3884021

申请日：1988-03-02

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKAZAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE ,  OHTOMO TSUYOSHI ,  KOMORI TAKASHI

IPC: A61K8/42 ,  A61K8/68 ,  A61Q5/00 ,  A61Q19/00 ,  C07H15/04 ,  A61K7/48

Abstract: An external skin care preparation comprising a compound represented by the following general formula (II), or a salt thereof: General formula (II): wherein R6 and R7 mean individually an aliphatic hydrocarbon group having 10-26 carbon atoms and R8 denotes a group -CH CH OH, -CH COOH or -COCH , and further comprising a surfactant.p

公开(公告)号：DE3884021D1

公开(公告)日：1993-10-21

申请号：DE3884021

申请日：1988-03-02

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKAZAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE ,  OHTOMO TSUYOSHI ,  KOMORI TAKASHI

IPC: A61K8/42 ,  A61K8/68 ,  A61Q5/00 ,  A61Q19/00 ,  C07H15/04 ,  A61K7/48

Abstract: An external skin care preparation comprising a compound represented by the following general formula (II), or a salt thereof: General formula (II): wherein R6 and R7 mean individually an aliphatic hydrocarbon group having 10-26 carbon atoms and R8 denotes a group -CH CH OH, -CH COOH or -COCH , and further comprising a surfactant.p

公开(公告)号：DE3854275T2

公开(公告)日：1996-04-11

申请号：DE3854275

申请日：1988-03-02

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKAZAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE ,  OHTOMO TSUYOSHI ,  KOMORI TAKASHI

IPC: A61K8/42 ,  A61K8/68 ,  A61Q5/00 ,  A61Q19/00 ,  C07H15/04 ,  A61K7/48

Abstract: An external skin care preparation comprising a compound represented by the following general formula (II), or a salt thereof: General formula (II): wherein R6 and R7 mean individually an aliphatic hydrocarbon group having 10-26 carbon atoms and R8 denotes a group -CH CH OH, -CH COOH or -COCH , and further comprising a surfactant.p

公开(公告)号：DE3854275D1

公开(公告)日：1995-09-07

申请号：DE3854275

申请日：1988-03-02

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKAZAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE ,  OHTOMO TSUYOSHI ,  KOMORI TAKASHI

IPC: A61K8/42 ,  A61K8/68 ,  A61Q5/00 ,  A61Q19/00 ,  C07H15/04 ,  A61K7/48

Abstract: An external skin care preparation comprising a compound represented by the following general formula (II), or a salt thereof: General formula (II): wherein R6 and R7 mean individually an aliphatic hydrocarbon group having 10-26 carbon atoms and R8 denotes a group -CH CH OH, -CH COOH or -COCH , and further comprising a surfactant.p

公开(公告)号：JPS63216812A

公开(公告)日：1988-09-09

申请号：JP5127687

申请日：1987-03-06

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKASAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/42 ,  A61K8/68 ,  A61K31/22 ,  A61P17/00 ,  A61Q5/00 ,  A61Q19/00 ,  C07C233/18 ,  C07C233/20 ,  C07H15/04

Abstract: PURPOSE:To obtain a skin drug for external use, containing a specific amide derivative, capable of enhancing moisture holding power of keratinous layers and exhibiting excellent improving and preventive effects on roughening of the skin. CONSTITUTION:A skin drug for external use obtained by containing a compound expressed by formula I (R is 10-26C hydrocarbon group; R is 9-25C hydrocar bon group; n is 3-6), e.g. N-(2-hydroxyl-3-hexadecyloxypropyl)-N-3-hydroxy propylhexadacanamide, in an amount of 0.001-50wt.%, preferably 0.1-20wt.% based on the total composition. Effects are further increased by additionally blending 0.01-20wt.% preferably 0.1-5wt.% surfactant, particularly nonionic surfactant. The compound expressed by formula I is prepared by reacting a glycidyl ether expressed by formula II with an amino-alcohol expressed by formula III and then selectively acylating the amino group of the resultant compound expressed by formula IV.

公开(公告)号：JPS63218609A

公开(公告)日：1988-09-12

申请号：JP5376987

申请日：1987-03-09

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKASAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/42 ,  A61K8/68 ,  A61K31/16 ,  A61K31/22 ,  A61P17/00 ,  A61Q5/00 ,  A61Q19/00 ,  C07C67/00 ,  C07C231/00 ,  C07C233/18 ,  C07C233/20 ,  C07H15/04

Abstract: NEW MATERIAL:The amide derivative of formula I (R and R are straight- or branched-chain saturated or unsaturated hydrocarbon group; the carbon numbers of R and R are 10-26 and 9-25, respectively; X-Z are H, 1-5C alkyl or hydroxyalkyl; X, Y and Z are not H at the same time). EXAMPLE:N-(2-hydroxy-3-hexadecyloxypropyl)-N-2, 3-dihydroxypropyl-hexadeca namide. USE:An active component for external drug for skin exhibiting excellent ameliorating and preventive effect against chapped skin owing to the radically improving effect of the compound on the water-retaining capability of cuticle layer. PREPARATION:The compound of formula I can be produced by acylating a compound of formula II derived from a compound of formula III and a compound of formula IV and selectively hydrolyzing the ester group of the resultant compound of formula V. The above effect can be further improved by the combined use of the compound with a surfactant.

公开(公告)号：JPS63297309A

公开(公告)日：1988-12-05

申请号：JP13205487

申请日：1987-05-28

Applicant: KAO CORP

Inventor： KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKASAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/42 ,  A61K8/55 ,  A61K8/58 ,  A61K8/68 ,  A61K33/42 ,  A61P17/00 ,  A61Q5/00 ,  A61Q19/00 ,  C07F9/10 ,  C07H15/04

Abstract: PURPOSE:To obtain a skin drug for external use, containing a specific lipid derivative and surfactant and capable of enhancing water holding power of a keratinous layer and improving roughening of the skin. CONSTITUTION:A medicinal skin drug for external use or cosmetic (e.g. cream, milky lotion, toilet water, lipstick, foundation or hairdressing) containing a lipid derivative expressed by formula I [R1 is 10-26C alkyl; R2 is 9-25C alkyl; X and Y are H or phosphoric acid ester group expressed by formula II (R3-R5 are H, 1-6C alkyl or aralkyl), provided that X and Y are not H at the same time]. The amount of the blended compound expressed by formula I is preferably 0.1-20wt.% based on the total composition in the case of an emulsion type agent and 5-25wt.% in the case of an oily agent containing a liquid hydrocarbon as a base. The surfactant has action on enhancement of effects and a glyceryl ether expressed by formula III [R6 is 8-24C alkyl, especially preferably a group expressed by formula IV (p is 4-10; q is 5-11)] is preferred. The amount thereof blended is 0.1-5wt.% based on the total composition.

公开(公告)号：JPS63227513A

公开(公告)日：1988-09-21

申请号：JP6071887

申请日：1987-03-16

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKASAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/42 ,  A61K8/68 ,  A61K31/22 ,  A61P17/00 ,  A61Q5/00 ,  A61Q19/00 ,  C07C67/00 ,  C07C231/00 ,  C07C233/18 ,  C07C233/20 ,  C07H15/04

Abstract: PURPOSE:To obtain a dermatic drug for external application effective in increasing water-retainability of corneum and ameliorating chapped skin, by using a specific amide derivative as essential component. CONSTITUTION:The objective agent contains a compound of formula I [R is 10-26C hydrocarbon group; R is 9-25C hydrocarbon group; m is integer of >=0; n is integer of >=1 (excluding the case of m=0 and n=1) [e.g. N-(2- hydroxy-3-hexadecyloxypropyl)-N-2-hydroxyethoxyethylhe-xadecanamide]. Preferably, the amount of the compound is 0.001-50wt.%, especially 0.1-20% for emulsion-type external drug and 1-50%, especially 5-25% for oil-based external drug for skin. It is preferable to compound 0.01-20% surfactant. The compound of formula I can be produced by acylating a compound of formula II with a fatty acid chloride of formula R COCl and selectively hydrolyzing the ester group of the resultant compound of formula III.

公开(公告)号：JPS6479195A

公开(公告)日：1989-03-24

申请号：JP13342688

申请日：1988-05-31

Applicant: KAO CORP

Inventor： KAWAMATA AKIRA ,  YAMADA SHINJI ,  MINEMATSU YOSHIHIRO ,  AKASAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE

IPC: A61K8/60 ,  A61K8/00 ,  A61K8/68 ,  A61K31/70 ,  A61K31/7028 ,  A61P17/00 ,  A61P43/00 ,  A61Q19/00 ,  C07H15/04

Abstract: NEW MATERIAL:A compound expressed by formula I (R1 is 10-26C alkyl; R2 is 9-25C alkyl; X and Y are H or saccharide residue and both will not be H at the same time). EXAMPLE:N-( 3-Hexadecyloxy-2-hydroxypropyl)-N-(2-O-D-glucopyranosyl)ethyl )hexadecanamide. USE:A dermal agent for external use. PREPARATION:For example, a glycidyl ether expressed by formula II is reacted with ethanolamine and only the amino group of the resultant product is selective ly acylated to provide a compound expressed by formula III. Either of primary and secondary hydroxyl groups in the resultant compound expressed by formula III is then protected and the protected compound is subsequently reacted with O-(2,3,4,6-tetra-O-benzyl-alpha-D-glycopyranosyl)trichloroacet-imidate in the presence of boron trifluoride etherate. The protecting group is subsequently removed to afford the aimed compound expressed by formula I.