公开(公告)号：WO2014209033A1

公开(公告)日：2014-12-31

申请号：PCT/KR2014/005686

申请日：2014-06-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： KIM, Dong Jin ,  KIM, Young Soo ,  KIM, Hye Yun ,  KIM, Hyun Jin

IPC: A61K31/5375 ,  A61K31/4965 ,  A61K31/445 ,  A61P25/16

CPC classification number: C07D295/15 ,  A61K31/495 ,  A61K31/5375 ,  C07D295/088

Abstract: Provided is a pharmaceutical composition for preventing or treating a cognitive impairment-related disease, the pharmaceutical composition including N-(2-hydroxyethyl)piperazine-N'(3-propane sulfonic acid), a pharmaceutically acceptable salt thereof or a derivative thereof, and donepezil, a pharmaceutically acceptable salt thereof or a derivative thereof. The composition may be used in preventing or treating a cognitive impairment-related disease.

Abstract translation: 提供了用于预防或治疗认知障碍相关疾病的药物组合物，所述药物组合物包括N-（2-羟乙基）哌嗪-N'（3-丙磺酸），其药学上可接受的盐或其衍生物，以及 多奈哌齐，其药学上可接受的盐或其衍生物。 该组合物可用于预防或治疗认知障碍相关疾病。

公开(公告)号：EP3013346A1

公开(公告)日：2016-05-04

申请号：EP14817212.5

申请日：2014-06-26

Applicant: Korea Institute of Science and Technology

Inventor： KIM, Dong Jin ,  KIM, Young Soo ,  KIM, Hye Yun ,  KIM, Hyun Jin

IPC: A61K31/5375 ,  A61K31/4965 ,  A61K31/445 ,  A61P25/16

CPC classification number: C07D295/15 ,  A61K31/495 ,  A61K31/5375 ,  C07D295/088

Abstract: Provided is a pharmaceutical composition for preventing or treating a cognitive impairment-related disease, the pharmaceutical composition including N-(2-hydroxyethyl)piperazine-N'(3-propane sulfonic acid), a pharmaceutically acceptable salt thereof or a derivative thereof, and donepezil, a pharmaceutically acceptable salt thereof or a derivative thereof. The composition may be used in preventing or treating a cognitive impairment-related disease.