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1.发明申请PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF PARKINSON'S DISEASE CONTAINING 1,2-DI[2-METHOXY-4-(2-CARBOXYLVINYL)]PHENOXYETHANE AS AN ACTIVE INGREDIENT 审中-公开用于预防和治疗含有1,2-二[2-甲氧基-4-（2-羧基乙基）]苯氧基乙烷作为活性成分的帕金森病的药物组合物
公开(公告)号：WO2008048053A1
公开(公告)日：2008-04-24
申请号：PCT/KR2007/005102
申请日：2007-10-18
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , SHIN, Kye Jung , KIM, Dong Jin , HWANG, Onyou
Inventor： SHIN, Kye Jung , KIM, Dong Jin , HWANG, Onyou
IPC: A61K31/194
CPC classification number: A61K31/194
Abstract: Having protective activity on dopaminergic neurons against toxic substances including l-methyl-4-phenylpyridinum (MPP+), tetrahydrobiopterin (BH4), hydrogen peroxide (H2O2) and l-methyl-4-phenyl-l, 2,4, β-tetrahyropyridine, 1, 2-di [2-methoxy- 4- (2-carboxylvinyl) ] phenoxyethane having the following chemical structure can be useful in the prevention and treatment of Parkinson's disease.
Abstract translation: 对多巴胺能神经元具有针对有毒物质（包括1-甲基-4-苯基吡啶（MPP +）），四氢生物喋呤（BH4），过氧化氢（H 2 O 2）和1-甲基-4-苯基-1,2,4-ß-四氢吡啶， 具有以下化学结构的1,2-二[2-甲氧基-4-（2-羧基乙烯基）]苯氧基乙烷可用于预防和治疗帕金森病。
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2.发明申请AMINOSTYRYLBENZOFURAN DERIVATIVES AS INHIBITORS AGAINST BETA-AMYLOID FIBRIL FORMATION, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开作为抗β-淀粉样蛋白形成的抑制剂的氨基苯酚苯并呋喃衍生物和包含其的药物组合物
公开(公告)号：WO2013147568A1
公开(公告)日：2013-10-03
申请号：PCT/KR2013/002699
申请日：2013-04-01
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： KIM, Dong Jin , YOO, Kyung Ho , KIM, Young Soo , PARK, Woong Seo , KANG, Yong Koo , KIM, Hye Yun , KIM, Yun Kyung , PARK, Ki Duk , KIM, Maeng Sup , SUH, Kwee Hyun , AHN, Young Gil
IPC: C07D413/12 , C07D307/86 , A61K31/421 , A61P25/00
CPC classification number: C07D413/12 , C07D307/81 , C07D405/12
Abstract: The present invention provides an aminostyrylbenzofuran compound of Formula (I), and a pharmaceutical composition comprising same. The pharmaceutical composition of the present invention comprising the compound of Formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof as an active ingredient can be useful for the prevention and treatment of degenerative brain diseases caused by accumulation of beta-amyloid.
Abstract translation: 本发明提供式（I）的氨基苯乙烯基苯并呋喃化合物和包含其的药物组合物。 包含式（I）化合物，其药学上可接受的盐，异构体，水合物和溶剂合物作为活性成分的本发明的药物组合物可用于预防和治疗由积累引起的退行性脑病 的β-淀粉样蛋白。
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3.发明申请STYRYLBENZOFURAN DERIVATIVES AS INHIBITORS FOR BETA-AMYLOID FIBRIL FORMATION AND PREPARATION METHOD THEREOF 审中-公开作为抗坏血酸纤维素形成的抑制剂的苯乙烯苯并呋喃衍生物及其制备方法
公开(公告)号：WO2009151299A2
公开(公告)日：2009-12-17
申请号：PCT/KR2009/003165
申请日：2009-06-12
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , HANMI PHARM. CO., LTD. , KIM, Dong Jin , YOO, Kyung Ho , BYUN, Ji Hun , KIM, YoungSoo , KIM, Hye Yun , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , LEE, Ji Hoon , LEE, Myoung-Hwan , HWANG, Hana , RYU, Jiyeon
Inventor： KIM, Dong Jin , YOO, Kyung Ho , BYUN, Ji Hun , KIM, YoungSoo , KIM, Hye Yun , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , LEE, Ji Hoon , LEE, Myoung-Hwan , HWANG, Hana , RYU, Jiyeon
IPC: C07D307/78
CPC classification number: C07D307/81 , C07D307/80
Abstract: The present invention relates to a novel compound which efficiently inhibits the formation of beta-amyloid fibrils in the brain to be useful for preventing or treating a degenerative brain disease, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.
Abstract translation: 本发明涉及有效抑制脑中β-淀粉样蛋白原纤维形成以用于预防或治疗退行性脑病的新型化合物，其制备方法和含有该衍生物作为活性成分的药物组合物。
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4.发明申请PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING COGNITIVE IMPAIRMENT-RELATED DISEASE COMPRISING MORPHOLINE OR PIPERAZINE BASED COMPOUNDS, AND DONEPEZIL 审中-公开用于预防或治疗包含吗啡或基于哌啶的化合物的认知性相关疾病的药物组合物和多西他赛
公开(公告)号：WO2014209033A1
公开(公告)日：2014-12-31
申请号：PCT/KR2014/005686
申请日：2014-06-26
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： KIM, Dong Jin , KIM, Young Soo , KIM, Hye Yun , KIM, Hyun Jin
IPC: A61K31/5375 , A61K31/4965 , A61K31/445 , A61P25/16
CPC classification number: C07D295/15 , A61K31/495 , A61K31/5375 , C07D295/088
Abstract: Provided is a pharmaceutical composition for preventing or treating a cognitive impairment-related disease, the pharmaceutical composition including N-(2-hydroxyethyl)piperazine-N'(3-propane sulfonic acid), a pharmaceutically acceptable salt thereof or a derivative thereof, and donepezil, a pharmaceutically acceptable salt thereof or a derivative thereof. The composition may be used in preventing or treating a cognitive impairment-related disease.
Abstract translation: 提供了用于预防或治疗认知障碍相关疾病的药物组合物，所述药物组合物包括N-（2-羟乙基）哌嗪-N'（3-丙磺酸），其药学上可接受的盐或其衍生物，以及 多奈哌齐，其药学上可接受的盐或其衍生物。 该组合物可用于预防或治疗认知障碍相关疾病。
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5.发明申请NOVEL ISOINDOLINONE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST T-TYPE CALCIUM CHANNEL AND METHOD FOR PREPARATION THEREOF 审中-公开具有抗T型钙通道的抑制活性的新型茚二酮衍生物及其制备方法
公开(公告)号：WO2010005148A2
公开(公告)日：2010-01-14
申请号：PCT/KR2008/005784
申请日：2008-10-01
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , CHO, Yong Seo , PAE, Ae Nim , CHOO, Hyunah , LEE, Jae Kyun , OH, You Na , SHIN, Hee Sup , KIM, Dong Jin , HAHN, Hoh Gyu , CHOI, Kyung Il , NAM, Ghilsoo , SHIN, Kye Jung , KANG, Soon Bang , ROH, Eun Joo , SHIN, Dong Yun , SEO, Seon Hee , RHIM, Hyewhon , KEUM, Gyo Chang , KIM, Key-Sun , CHEONG, Chan Seong , KIM, Eunice Eun-Kyeong , LEE, Cheolju , KIM, Youngsoo , CHOI, Kee Hyun , NAM, Kee Dal , PARK, Woong Seo , KANG, Yong Koo , CHUNG, Hye Jin
Inventor： CHO, Yong Seo , PAE, Ae Nim , CHOO, Hyunah , LEE, Jae Kyun , OH, You Na , SHIN, Hee Sup , KIM, Dong Jin , HAHN, Hoh Gyu , CHOI, Kyung Il , NAM, Ghilsoo , SHIN, Kye Jung , KANG, Soon Bang , ROH, Eun Joo , SHIN, Dong Yun , SEO, Seon Hee , RHIM, Hyewhon , KEUM, Gyo Chang , KIM, Key-Sun , CHEONG, Chan Seong , KIM, Eunice Eun-Kyeong , LEE, Cheolju , KIM, Youngsoo , CHOI, Kee Hyun , NAM, Kee Dal , PARK, Woong Seo , KANG, Yong Koo , CHUNG, Hye Jin
IPC: C07D403/12
CPC classification number: C07D401/12 , A61K31/454
Abstract: Disclosed are isoindolinone derivatives having inhibitory activity against T-type calcium channels, pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an active ingredient.
Abstract translation: 公开了对T型钙通道具有抑制活性的异吲哚啉酮衍生物，其药学上可接受的盐，其制备方法和包含其的作为活性成分的药物组合物。
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Patent Agency Ranking6.发明申请COMPOUND FOR INHIBITING THE FORMATION OF BETA-AMYLOID FIBRIL, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开用于抑制形成β-淀粉样纤维的化合物，其制备方法和包含其的药物组合物
公开(公告)号：WO2008030072A1
公开(公告)日：2008-03-13
申请号：PCT/KR2007/004364
申请日：2007-09-10
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , HANMI PHARM. CO., LTD. , KIM, Dong Chan , KIM, Dong Jin , YOO, Kyung Ho , SHIN, Kye Jung , BYEON, Seong Rim , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , MOOK, Inhee
Inventor： KIM, Dong Chan , KIM, Dong Jin , YOO, Kyung Ho , SHIN, Kye Jung , BYEON, Seong Rim , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , MOOK, Inhee
IPC: C07D213/34
CPC classification number: C07D213/38 , C07D213/30
Abstract: The present invention relates to a novel compound which is effective in inhibiting the formation of beta-amyloid fibril in the brain, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.
Abstract translation: 本发明涉及一种有效抑制脑中β-淀粉样蛋白原纤维形成的新型化合物及其制备方法，以及含有作为活性成分的药物组合物。
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7.发明申请
公开(公告)号：WO2005121144A1
公开(公告)日：2005-12-22
申请号：PCT/KR2005/001798
申请日：2005-06-14
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , YOO, Kyung Ho , KIM, Dong Jin , KANG, Yong Koo , LEE, Kyung Seok , LEE, Gwan Sun , KIM, Maeng Sup , KANG, Jae Hoon
Inventor： YOO, Kyung Ho , KIM, Dong Jin , KANG, Yong Koo , LEE, Kyung Seok , LEE, Gwan Sun , KIM, Maeng Sup , KANG, Jae Hoon
IPC: C07D477/20
CPC classification number: C07D477/20
Abstract: The present invention relates to a novel 1β-methylcarbapenem derivative, a process for the preparation thereof and a pharmaceutical composition comprising the 1β-methylcarbapenem derivative or a pharmaceutically acceptable salt thereof as an active antibacterial ingredient.
Abstract translation: 本发明涉及一种新型的β-甲基碳青霉烯类衍生物，其制备方法和药物组合物，其包含作为活性抗菌成分的β-甲基碳青霉烯衍生物或其药学上可接受的盐。
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8.发明授权
公开(公告)号：EP2990801B1
公开(公告)日：2019-01-02
申请号：EP14788047.0
申请日：2014-04-25
Applicant: Korea Institute of Science and Technology
Inventor： KIM, Young Soo , KIM, Dong Jin , KIM, Hye Yun , CHO, Soo Min , LEE, Sejin , KIM, Hyunjin , KIM, Tae Song , HWANG, Kyoseon , ROH, Jee Hoon , KOH, Jae-Young
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9.发明公开STYRYLBENZOFURAN DERIVATIVES AS INHIBITORS FOR BETA-AMYLOID FIBRIL FORMATION AND PREPARATION METHOD THEREOF 审中-公开作为β-淀粉样蛋白纤维形成抑制剂的STYRYLBENZOFURAN衍生物及其制备方法
公开(公告)号：EP2291364A2
公开(公告)日：2011-03-09
申请号：EP09762685.7
申请日：2009-06-12
Inventor： KIM, Dong Jin , YOO, Kyung Ho , BYUN, Ji Hun , KIM, YoungSoo , KIM, Hye Yun , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , LEE, Ji Hoon , LEE, Myoung-Hwan , HWANG, Hana , RYU, Jiyeon
IPC: C07D307/78 , A61K31/343
CPC classification number: C07D307/81 , C07D307/80
Abstract: The present invention relates to a novel compound which efficiently inhibits the formation of beta-amyloid fibrils in the brain to be useful for preventing or treating a degenerative brain disease, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.
Abstract translation: 本发明涉及有效抑制脑中β-淀粉样原纤维形成以用于预防或治疗退行性脑疾病的新型化合物，其制备方法，以及包含其作为活性成分的药物组合物。
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公开(公告)号：EP1023294A1
公开(公告)日：2000-08-02
申请号：EP98941881.9
申请日：1998-08-21
Inventor： PARK, Sang Woo , KIM, Dong Jin , SHIN, Kye Jung , KAGN, Yong Koo , KIM, Yong Zu , CHUNG, Yong Ho , LEE, Hong Woo , HUH, Jae Doo , LEE, Sang Joo , SUH, Il Hong , KO, Bong Suk
IPC: C07D477/20 , A61K31/40
CPC classification number: C07D477/20 , C07D207/16 , Y02P20/55
Abstract: The present invention relates to carbapenem derivatives represented by formula (I) and a preparation method thereof. The preparation method comprises first preparing the carbapenem intermediate represented by formula (VII) by reacting the carbapenem nucleus of formula (II) with diphenylchlorophosphate or trifluoromethanesulfonic anhydride in the presence of a base. Then the carbapenem intermediate represented by formula (VII) is reacted with a thiol derivative represented by formula (III) to produce the carbapenem derivatives represented by formula (I). The carbapenem derivatives represented by formula (I) of the present invention have excellent antibacterial properties and thus can be used as antibiotics.
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