-
1.发明申请STYRYLBENZOFURAN DERIVATIVES AS INHIBITORS FOR BETA-AMYLOID FIBRIL FORMATION AND PREPARATION METHOD THEREOF 审中-公开作为抗坏血酸纤维素形成的抑制剂的苯乙烯苯并呋喃衍生物及其制备方法
公开(公告)号：WO2009151299A2
公开(公告)日：2009-12-17
申请号：PCT/KR2009/003165
申请日：2009-06-12
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , HANMI PHARM. CO., LTD. , KIM, Dong Jin , YOO, Kyung Ho , BYUN, Ji Hun , KIM, YoungSoo , KIM, Hye Yun , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , LEE, Ji Hoon , LEE, Myoung-Hwan , HWANG, Hana , RYU, Jiyeon
Inventor： KIM, Dong Jin , YOO, Kyung Ho , BYUN, Ji Hun , KIM, YoungSoo , KIM, Hye Yun , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , LEE, Ji Hoon , LEE, Myoung-Hwan , HWANG, Hana , RYU, Jiyeon
IPC: C07D307/78
CPC classification number: C07D307/81 , C07D307/80
Abstract: The present invention relates to a novel compound which efficiently inhibits the formation of beta-amyloid fibrils in the brain to be useful for preventing or treating a degenerative brain disease, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.
Abstract translation: 本发明涉及有效抑制脑中β-淀粉样蛋白原纤维形成以用于预防或治疗退行性脑病的新型化合物，其制备方法和含有该衍生物作为活性成分的药物组合物。
-
2.发明申请AMINOSTYRYLBENZOFURAN DERIVATIVES AS INHIBITORS AGAINST BETA-AMYLOID FIBRIL FORMATION, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开作为抗β-淀粉样蛋白形成的抑制剂的氨基苯酚苯并呋喃衍生物和包含其的药物组合物
公开(公告)号：WO2013147568A1
公开(公告)日：2013-10-03
申请号：PCT/KR2013/002699
申请日：2013-04-01
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： KIM, Dong Jin , YOO, Kyung Ho , KIM, Young Soo , PARK, Woong Seo , KANG, Yong Koo , KIM, Hye Yun , KIM, Yun Kyung , PARK, Ki Duk , KIM, Maeng Sup , SUH, Kwee Hyun , AHN, Young Gil
IPC: C07D413/12 , C07D307/86 , A61K31/421 , A61P25/00
CPC classification number: C07D413/12 , C07D307/81 , C07D405/12
Abstract: The present invention provides an aminostyrylbenzofuran compound of Formula (I), and a pharmaceutical composition comprising same. The pharmaceutical composition of the present invention comprising the compound of Formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof as an active ingredient can be useful for the prevention and treatment of degenerative brain diseases caused by accumulation of beta-amyloid.
Abstract translation: 本发明提供式（I）的氨基苯乙烯基苯并呋喃化合物和包含其的药物组合物。 包含式（I）化合物，其药学上可接受的盐，异构体，水合物和溶剂合物作为活性成分的本发明的药物组合物可用于预防和治疗由积累引起的退行性脑病 的β-淀粉样蛋白。
-
公开(公告)号：WO2011049274A1
公开(公告)日：2011-04-28
申请号：PCT/KR2010/000589
申请日：2010-02-01
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , HAH, Jung-Mi , YOO, Kyung Ho , SIM, Tae-Bo , OH, Chang Hyun , LEE, Jung Hun , YU, Hana , KIM, Hwan
Inventor： HAH, Jung-Mi , YOO, Kyung Ho , SIM, Tae-Bo , OH, Chang Hyun , LEE, Jung Hun , YU, Hana , KIM, Hwan
IPC: C07D401/04 , C07D401/02 , A61K31/415 , A61P35/00
CPC classification number: C07D403/14 , A61K31/415 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: The present invention relates to novel imidazole derivatives or pharmaceutically acceptable salts thereof, preparation methods thereof and pharmaceutical compositions for prevention and treatment of melanoma containing the same as active ingredients. The novel imidazole derivatives or pharmaceutically acceptable salts thereof according to the present invention have excellent inhibitory effects on various protein kinases, which cause melanoma, such as B-RAF, C-RAF, Aurora-A, BTK, Flt3, Ret, KDR/VEGFR2, P38α/MAPK14, RAF1, FMS, and the like, so they can be used for the prevention and treatment of melanoma.
Abstract translation: 本发明涉及新颖的咪唑衍生物或其药学上可接受的盐，其制备方法和用于预防和治疗含有与活性成分相同的黑素瘤的药物组合物。 根据本发明的新型咪唑衍生物或其药学上可接受的盐对各种蛋白激酶具有优异的抑制作用，其引起黑素瘤，例如B-RAF，C-RAF，Aurora-A，BTK，Flt3，Ret，KDR / VEGFR2 ，P38a / MAPK14，RAF1，FMS等，因此可用于预防和治疗黑素瘤。
-
4.发明申请NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT 审中-公开新的吲唑衍生物或其医药可接受的盐作为用于增殖性疾病治疗的蛋白激酶抑制剂，以及含有该化合物作为活性成分的药物组合物
公开(公告)号：WO2010064875A2
公开(公告)日：2010-06-10
申请号：PCT/KR2009/007247
申请日：2009-12-04
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , SIM, Tae Bo , SON, Jung Beom , KIM, Hwan , PARK, Dong Sik , CHOI, Hwan Geun , HAM, Young Jin , HAH, Jung Mi , YOO, Kyung Ho , OH, Chang Hyun , LEE, So Ha , HA, Jae Du , CHO, Sung Yun , KWON, Byoung-Mog , HAN, Dong Cho
Inventor： SIM, Tae Bo , SON, Jung Beom , KIM, Hwan , PARK, Dong Sik , CHOI, Hwan Geun , HAM, Young Jin , HAH, Jung Mi , YOO, Kyung Ho , OH, Chang Hyun , LEE, So Ha , HA, Jae Du , CHO, Sung Yun , KWON, Byoung-Mog , HAN, Dong Cho
IPC: C07D231/56
CPC classification number: C07D413/14 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.
Abstract translation: 公开了由以下化学式1表示的新型吲唑衍生物或其药学上可接受的盐，水合物或溶剂化物，以及用于预防或治疗增殖性疾病的药物组合物，其含有作为活性成分的药物组合物。 新型吲唑衍生物对b-raf，KDR，Fms，Tie2，SAPK2a，Ret等蛋白激酶具有强效抑制作用，可诱导异常细胞增殖引起的疾病，可用于预防或治疗由异常细胞引起的疾病 增殖。
-
5.发明申请
公开(公告)号：WO2011052923A2
公开(公告)日：2011-05-05
申请号：PCT/KR2010/007205
申请日：2010-10-20
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , SIM, Tae Bo , HAM, Young Jin , YOO, Kyung Ho , OH, Chang Hyun , HAH, Jung Mi , CHOI, Hwan Geun , KIM, Hwan , JUN, Eun Jin
Inventor： SIM, Tae Bo , HAM, Young Jin , YOO, Kyung Ho , OH, Chang Hyun , HAH, Jung Mi , CHOI, Hwan Geun , KIM, Hwan , JUN, Eun Jin
IPC: C07D403/04 , C07D209/04 , A61K31/40 , A61P35/00
CPC classification number: C07D403/04 , A61K31/404 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
Abstract: Disclosed are a 1,6-substituted indole compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of cancers caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel indole compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.
Abstract translation: 公开了具有蛋白激酶抑制活性的1,6-取代的吲哚化合物，药学上可接受的盐，以及用于预防和治疗由包含该化合物作为有效成分的异常细胞生长引起的癌症的药物组合物。 由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。
-
Patent Agency Ranking6.发明申请COMPOUND FOR INHIBITING THE FORMATION OF BETA-AMYLOID FIBRIL, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开用于抑制形成β-淀粉样纤维的化合物，其制备方法和包含其的药物组合物
公开(公告)号：WO2008030072A1
公开(公告)日：2008-03-13
申请号：PCT/KR2007/004364
申请日：2007-09-10
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , HANMI PHARM. CO., LTD. , KIM, Dong Chan , KIM, Dong Jin , YOO, Kyung Ho , SHIN, Kye Jung , BYEON, Seong Rim , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , MOOK, Inhee
Inventor： KIM, Dong Chan , KIM, Dong Jin , YOO, Kyung Ho , SHIN, Kye Jung , BYEON, Seong Rim , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , MOOK, Inhee
IPC: C07D213/34
CPC classification number: C07D213/38 , C07D213/30
Abstract: The present invention relates to a novel compound which is effective in inhibiting the formation of beta-amyloid fibril in the brain, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.
Abstract translation: 本发明涉及一种有效抑制脑中β-淀粉样蛋白原纤维形成的新型化合物及其制备方法，以及含有作为活性成分的药物组合物。
-
7.发明申请
公开(公告)号：WO2005121144A1
公开(公告)日：2005-12-22
申请号：PCT/KR2005/001798
申请日：2005-06-14
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , YOO, Kyung Ho , KIM, Dong Jin , KANG, Yong Koo , LEE, Kyung Seok , LEE, Gwan Sun , KIM, Maeng Sup , KANG, Jae Hoon
Inventor： YOO, Kyung Ho , KIM, Dong Jin , KANG, Yong Koo , LEE, Kyung Seok , LEE, Gwan Sun , KIM, Maeng Sup , KANG, Jae Hoon
IPC: C07D477/20
CPC classification number: C07D477/20
Abstract: The present invention relates to a novel 1β-methylcarbapenem derivative, a process for the preparation thereof and a pharmaceutical composition comprising the 1β-methylcarbapenem derivative or a pharmaceutically acceptable salt thereof as an active antibacterial ingredient.
Abstract translation: 本发明涉及一种新型的β-甲基碳青霉烯类衍生物，其制备方法和药物组合物，其包含作为活性抗菌成分的β-甲基碳青霉烯衍生物或其药学上可接受的盐。
-
8.发明公开
公开(公告)号：EP3483166A1
公开(公告)日：2019-05-15
申请号：EP17824476.0
申请日：2017-07-03
Applicant: Korea Institute of Science and Technology
Inventor： MAHMOUD, Gamal El-din , CHOI, Hong Seok , YOO, Kyung Ho , HAN, Dong Keun , OH, Chang Hyun , MOHAMMED, Abdel-Maksoud , MOHAMMED, I. El-Gamal
IPC: C07D498/04 , C07D513/04 , C07D417/14 , A61K31/424 , A61K31/429 , A61K31/433 , A61K31/506
Abstract: Provided is a pharmaceutical composition for preventing and treating tumors, the pharmaceutical composition including an imidazooxazole derivative compound, a solvate, a stereoisomer, or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is administered to an entity which has developed a tumor or is in danger of developing a tumor, and thus tumors can be prevented or treated.
-
9.发明公开
公开(公告)号：EP3845539A1
公开(公告)日：2021-07-07
申请号：EP20153435.1
申请日：2020-01-23
Applicant: Korea Institute of Science and Technology
Inventor： MAHMOUD, Gamal El-din , CHOI, Hong Seok , YOO, Kyung Ho , HAN, Dong Keun , OH, Chang Hyun , MOHAMMED, Abdel-Maksoud , MOHAMMED, El-Gamal I. , AMMAR, Usama M.
IPC: C07D498/04 , C07D513/04 , A61P35/00 , A61K31/424 , A61K31/429
Abstract: Provided is a pharmaceutical composition for use in preventing and treating tumors, the pharmaceutical composition including an imidazooxazole derivative compound, a solvate, a stereoisomer, or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is administered to an entity which has developed a tumor or is in danger of developing a tumor, and thus tumors can be prevented or treated.
-
10.发明公开STYRYLBENZOFURAN DERIVATIVES AS INHIBITORS FOR BETA-AMYLOID FIBRIL FORMATION AND PREPARATION METHOD THEREOF 审中-公开作为β-淀粉样蛋白纤维形成抑制剂的STYRYLBENZOFURAN衍生物及其制备方法
公开(公告)号：EP2291364A2
公开(公告)日：2011-03-09
申请号：EP09762685.7
申请日：2009-06-12
Inventor： KIM, Dong Jin , YOO, Kyung Ho , BYUN, Ji Hun , KIM, YoungSoo , KIM, Hye Yun , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , LEE, Ji Hoon , LEE, Myoung-Hwan , HWANG, Hana , RYU, Jiyeon
IPC: C07D307/78 , A61K31/343
CPC classification number: C07D307/81 , C07D307/80
Abstract: The present invention relates to a novel compound which efficiently inhibits the formation of beta-amyloid fibrils in the brain to be useful for preventing or treating a degenerative brain disease, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.
Abstract translation: 本发明涉及有效抑制脑中β-淀粉样原纤维形成以用于预防或治疗退行性脑疾病的新型化合物，其制备方法，以及包含其作为活性成分的药物组合物。
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.032 seconds)
