公开(公告)号：US20240337591A1

公开(公告)日：2024-10-10

申请号：US18604754

申请日：2024-03-14

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Dong Hyung KIM ,  Hyun Mo CHO

IPC: G01N21/21 ,  G01N21/552 ,  G01N21/84

CPC classification number: G01N21/211 ,  G01N21/554 ,  G01N21/8422 ,  G01N2021/213

Abstract: A split prism silicon-based immersion microchannel measuring device includes a microchannel structure including a support and one or more microchannels formed in the support and each having a sample detection layer with a fixed bioadhesive material for detecting a sample, a sample injection unit configured to inject a buffer solution containing the sample into the microchannel, a prism unit having a first prism and a second prism and formed by connecting a vertical surface of the first prism and a vertical surface of the second prism, a blocking part provided in a portion where the first prism and the second prism are connected to each other, the blocking part being configured to block an optical path, a polarized light generating unit configured to generate polarized light, and a polarized light detecting unit configured to detect a polarization change of reflected light.

公开(公告)号：US20230168185A1

公开(公告)日：2023-06-01

申请号：US17921706

申请日：2020-09-21

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Hyun Mo CHO ,  Dong Hyung KIM ,  Won CHEGAL ,  Yong Jai CHO

IPC: G01N21/21 ,  G01N21/11

CPC classification number: G01N21/211 ,  G01N21/11 ,  G01N2021/752

Abstract: An embodiment of the present disclosure provides a multi-reflection silicon-based liquid immersion micro-channel measurement device and measurement method capable of improving measurement sensitivity by completely separating, through multi-reflection, first reflective light reflected by a sample detection layer and a second reflective light by a prism-buffer solution interface and by allowing the light to enter multiple times through the multi-reflection. The multi-reflection silicon-based liquid immersion micro-channel measurement device according to the embodiment of the present disclosure includes a micro-channel structure including a support, and one or more micro-channels formed on the support and each having a sample detection layer with a fixed bioadhesive material for detecting a sample, a sample injection unit configured to inject a buffer solution containing the sample into the micro-channel, a prism unit including a prism, and a reflection structure formed by coating a bottom surface of the prism with a mirror reflection material, the polarized light generating unit configured to generate polarized light, and the polarized light detecting unit configured to detect a polarization change of reflected light.