公开(公告)号：US12270762B2

公开(公告)日：2025-04-08

申请号：US16982850

申请日：2019-09-18

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Eun-Ah You ,  Wansun Kim ,  Tae Geol Lee

IPC: G01N21/65 ,  B82B1/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N33/483 ,  G01N33/553

Abstract: Provided is a Raman-active particle which is a Raman-active particle for surface-enhanced Raman analysis, the particle including: a spherical plasmonic metal core; a plasmonic metal shell having surface unevenness; and a self-assembled monolayer which is bonded to each of the core and the shell and positioned between the core and the shell, and includes a Raman reporter.

公开(公告)号：US12140547B2

公开(公告)日：2024-11-12

申请号：US17587541

申请日：2022-01-28

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE ,  VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Eun-Ah You ,  Zhou Wei ,  Wonil Nam ,  Wansun Kim

IPC: G01N21/65 ,  B82Y35/00 ,  B82Y40/00 ,  G01N33/68

Abstract: The present disclosure relates to a surface-enhanced Raman spectroscopy complex probe capable of effectively detecting a catecholamine compound even at extremely low concentrations. The complex probe includes a nanolaminate including a nanogap and metal nanoparticles. In this case, the nanolaminate and the metal nanoparticles are modified to a compound that may be bound to each functional group included in catecholamine, and thus, catecholamine included in an analyte is doubly recognized by the complex probe. In addition, since a hotspot emitting a strong SERS signal is formed by a nanogap included in a nanolaminate, it is possible to effectively detect a catecholamine compound even at extremely low concentrations.

公开(公告)号：US12013393B2

公开(公告)日：2024-06-18

申请号：US16498326

申请日：2018-10-10

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Eun-Ah You ,  Wansun Kim ,  Tae Geol Lee

IPC: G01N33/553 ,  B82Y30/00 ,  G01N33/543 ,  B82B1/00 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  G01N21/65

CPC classification number: G01N33/54346 ,  G01N33/553 ,  B82B1/008 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  G01N21/658

Abstract: Provided is a method of preparing Raman-active nanoparticles, which includes a) preparing a metal nanocore having a nano-star shape from a first reaction solution in which a first metal precursor is mixed with a buffer solution; b) fixing a Raman reporter in the metal nanocore; and c) forming a metal shell, which surrounds the nanocore in which the Raman reporter is fixed, from a second reaction solution in which a second metal precursor is mixed with the nanocore in which the Raman reporter is fixed. The Raman reporter has a binding affinity for each of a first metal of the metal nanocore and a second metal of the metal shell.

公开(公告)号：US11479474B2

公开(公告)日：2022-10-25

申请号：US16498307

申请日：2018-10-23

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Eun-Ah You ,  Wansun Kim ,  Tae Geol Lee

IPC: C01G7/00 ,  G01N21/65 ,  B82B1/00 ,  G01N33/543 ,  G01N33/553 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00

Abstract: Provided is a method of preparing composite nanoparticles, which includes: a) preparing a metal nanocore having a nano-star shape from a first reaction solution in which a first metal precursor is mixed with a first buffer solution; b) fixing a Raman reporter in the metal nanocore; and c) forming a metal shell, which surrounds the nanocore in which the Raman reporter is fixed, from a second reaction solution in which the nanocore in which the Raman reporter is fixed, and a second metal precursor are mixed with a second buffer solution.