公开(公告)号：JPS6216954B2

公开(公告)日：1987-04-15

申请号：JP4640578

申请日：1978-04-19

Applicant: KOWA CO

Inventor： HIROBE MASAAKI ,  KASUYA YUTAKA ,  OOTA TOMIO

IPC: C07D491/044 ,  A61K31/55 ,  A61P25/24 ,  A61P25/26 ,  C07D491/04

公开(公告)号：JPS60226876A

公开(公告)日：1985-11-12

申请号：JP8322884

申请日：1984-04-25

Applicant: KOWA CO

Inventor： ISHIHAMA HIROSHI ,  OOTA TOMIO ,  SHIMIZU NOBORU ,  ISHIWATARI HIROYUKI ,  UCHIDA YASUYOSHI

IPC: C07D211/90 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/455 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D211/00 ,  C07D213/00 ,  C07D233/00 ,  C07D401/12 ,  C07D401/14

Abstract: NEW MATERIAL:The compound of formula I [R1 and R2 are H, halogen, trihalomethyl or nitro; R3 is lower alkyl or group of formula II (B is 7-16C alkylene); A is C or N]. EXAMPLE:2,6-Demethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarbo xylic acid 3-methyl ester 5-[8-(1-imidarzolyl)octyl] ester. USE:A drug having vasodilating, blood flow increasing, thrombocyte coagulation inhibiting, and thromboxane-A2 formation inhibiting activities, and useful as a vasodilator, hypotensor, an antithrombotic agent, an antiarteriosclerotic agent, etc. The coronary blood flow can be increased and keeps the high level for a long period by the administration of the compound. PREPARATION:The compound of formula I can be prepared e.g. by reacting the compound of formula III (Y is active group) with imidazole or its alkali metal salt in an inert solvent at room temperature -80 deg.C for several -24hr while stirring.

公开(公告)号：JPS6024106B2

公开(公告)日：1985-06-11

申请号：JP11451775

申请日：1975-09-22

Applicant: KOWA CO

Inventor： NAGAKURA MASAHIKO ,  OOTA TOMIO ,  KUNIEDA HISASHI

IPC: C07D311/86

公开(公告)号：JPS6025958A

公开(公告)日：1985-02-08

申请号：JP13184583

申请日：1983-07-21

Applicant: KOWA CO

Inventor： UCHIDA YASUYOSHI ,  SHIGIYOU HIROMICHI ,  SATOU SEIICHI ,  SHIBUYA MASAYUKI ,  OOTA TOMIO ,  ISHIHAMA HIROSHI

IPC: C07D295/14 ,  C07C45/67 ,  C07C67/00 ,  C07C203/04 ,  C07C205/32 ,  C07C213/00 ,  C07C217/14 ,  C07C217/18 ,  C07C231/02 ,  C07C233/25 ,  C07C233/33 ,  C07C233/36 ,  C07C235/04 ,  C07C237/04 ,  C07C237/42 ,  C07D213/80 ,  C07D213/81 ,  C07D295/092 ,  C07D295/15

Abstract: NEW MATERIAL:The compound of formula I (R1 is H, lower alkyl, lower alkoxy, etc.; R2 is H or lower alkyl; R3 is nitroxy, trifluoromethyl or F; R4 and R5 are H, lower alkyl, halogen-substituted benzoyl, etc.; A is single bond, O imino, residue of -CONH-, etc.; B is O or residue of -NHCO-; X1 and X2 are aklylene). EXAMPLE:2-Dimethylamino-2'-methoxy-5'-(2-nitroxyethoxy)-acetanilide. USE:Useful as a drug for the circulatory system, e.g. hypotensor, anti-stenocardia, antiarrhythmic agent, etc. PREPARATION:The objective compound of e.g. formula II is produced by using a substituted aniline or a substituted phenol as a starting substance, and reacting e.g. a substituted aniline with a halogeno-aliphatic carboxylic acid or N-protected amino-apliphatic carboxylic acid and its reactive derivative.

公开(公告)号：JPS5780370A

公开(公告)日：1982-05-19

申请号：JP15530780

申请日：1980-11-05

Applicant: Kowa Co

Inventor： OOTA TOMIO ,  TAKAHASHI YOSHIO ,  TAKIMOTO MASAMI ,  NAGAKURA MASAHIKO

IPC: C07D213/30 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4418 ,  A61P3/06 ,  C07D213/64

Abstract: NEW MATERIAL:An α-methylcinnamic acid derivative expressed by formula I (R is H or lower alkyl; n is an integer 0W3) or a salt thereof.
EXAMPLE: α-Methyl-p-( 2-pyridylmethyloxy )-cinnamic acid.
USE: An antilipemic agent, having the ability to reduce the concentrations of cholesterol and triglycerides in blood, and suitably administered in a dose of 200W500mg/day.
PROCESS: A pyridine derivative expressed by formula II (X is halogen) is reacted with a p-hydorxy-α-methylcinnamic acid derivative expressed by formula III in a suitable inert solvent in the presence of an alkali under heating and refluxing for 2W3hr to give the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio

Abstract translation: 新材料：由式I表示的α-甲基肉桂酸衍生物（R为H或低级烷基; n为0-3的整数）或其盐。 实施例：α-甲基 - 对 - （2-吡啶基甲氧基） - 肉桂酸。 用途：具有减少血液中胆固醇和甘油三酯浓度的能力，并以200-500mg /天的剂量适当施用的抗血药物。 方法：将式II表示的吡啶衍生物（X为卤素）与式III表示的对羟基-α-甲基肉桂酸衍生物在合适的惰性溶剂中，在碱存在下，在加热下回流2-3小时 得到式I表示的化合物。

公开(公告)号：JPS5398969A

公开(公告)日：1978-08-29

申请号：JP1225977

申请日：1977-02-07

Applicant: KOWA CO

Inventor： OOTA TOMIO ,  YAMAGUCHI TAKASHI ,  ONOKI KAZUHIRO ,  NAGAKURA MASAHIKO

IPC: C07D311/86 ,  A61K31/35 ,  A61K31/352 ,  A61K31/415 ,  A61P3/08 ,  A61P25/04 ,  A61P37/00 ,  A61P43/00 ,  C07D405/04

公开(公告)号：JP2577222B2

公开(公告)日：1997-01-29

申请号：JP8702187

申请日：1987-04-10

Applicant: KOWA CO

Inventor： SHIBUYA MASAYUKI ,  TAKAHASHI YOSHIO ,  SATO SEIICHI ,  SHIGYO HIROMICHI ,  OOTA TOMIO ,  UCHIDA YASUYOSHI

IPC: C07D233/61 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61P9/06 ,  C07D213/04 ,  C07D213/30 ,  C07D213/40 ,  C07D213/50 ,  C07D213/70 ,  C07D213/79 ,  C07D213/80 ,  C07D213/82 ,  C07D213/89 ,  C07D233/54 ,  C07D233/64 ,  C07D233/84 ,  C07D471/04 ,  C07D521/00

公开(公告)号：JPH0564634B2

公开(公告)日：1993-09-16

申请号：JP5361485

申请日：1985-03-18

Applicant: KOWA CO

Inventor： SHIMIZU NOBORU ,  ISHIWATARI HIROYUKI ,  KUNIEDA HISASHI ,  OOTA TOMIO ,  ISHIHAMA HIROSHI ,  UCHIDA YASUYOSHI

IPC: C07D413/14 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/445 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D211/00 ,  C07D233/00 ,  C07D271/00 ,  C07D401/12 ,  C07D401/14

公开(公告)号：JPS6341392B2

公开(公告)日：1988-08-17

申请号：JP15530780

申请日：1980-11-05

Applicant: KOWA CO

Inventor： OOTA TOMIO ,  TAKAHASHI YOSHIO ,  TAKIMOTO MASAMI ,  NAGAKURA MASAHIKO

IPC: C07D213/30 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4418 ,  A61P3/06 ,  C07D213/64

公开(公告)号：JPS6323986B2

公开(公告)日：1988-05-18

申请号：JP10743980

申请日：1980-08-05

Applicant: KOWA CO

Inventor： OOTA TOMIO ,  TAKAHASHI YOSHIO ,  NAGAKURA MASAHIKO

IPC: C07D295/18 ,  A61K31/13 ,  A61K31/135 ,  A61K31/16 ,  A61K31/165 ,  A61K31/215 ,  A61K31/22 ,  A61K31/395 ,  A61P9/00 ,  C07C67/00 ,  C07C213/00 ,  C07C217/56 ,  C07C217/62 ,  C07C219/14 ,  C07C227/00 ,  C07C229/16 ,  C07C231/00 ,  C07C235/40 ,  C07D243/08 ,  C07D295/04 ,  C07D295/08 ,  C07D295/10 ,  C07D295/16