公开(公告)号：WO2011081329A2

公开(公告)日：2011-07-07

申请号：PCT/KR2010/008988

申请日：2010-12-15

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  PARK, Kyu Hwan ,  KIM, Hyun Sik ,  KWON, Kyung Hoon ,  YOO, Jong Shin

Inventor： PARK, Kyu Hwan ,  KIM, Hyun Sik ,  KWON, Kyung Hoon ,  YOO, Jong Shin

IPC: G01N30/72 ,  G01N33/15 ,  B01D15/08

CPC classification number: G01N30/06 ,  G01N30/8686 ,  G01N30/96 ,  G01N33/6848 ,  G01N2030/8809 ,  G01N2030/8813 ,  G01N2500/00 ,  Y10T436/174614 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25375

Abstract: Disclosed is a method for discovering pharmacologically active substances from natural products at high speed, including: obtaining an activity profile by testing pharmacological activity of a plurality of samples; obtaining a mass profile based on a mass spectrum resulting from analysis of the samples by mass spectrometry; and determining molecular weight of pharmacologically active substances by comparing and analyzing the activity profile and the mass profile. The disclosed method allows fast discovery of pharmacologically active substances by performing high resolution mass spectrometry for numerous components included in an extract sample of natural products and comparing with the activity test data. The information about the intensity of the activity of the pharmacologically active substances of the natural products allows effective utilization of the natural products.

Abstract translation: 公开了一种从天然产物中高速发现药理活性物质的方法，包括：通过测试多个样品的药理活性来获得活性曲线; 基于通过质谱法分析样品产生的质谱获得质量分布图; 并通过比较和分析活性曲线和质量曲线来确定药理活性物质的分子量。 所公开的方法通过对包含在天然产物的提取物样品中的许多组分进行高分辨质谱并且与活性测试数据进行比较而允许药理活性物质的快速发现。 有关天然产物药理活性物质活性强度的信息可以有效利用天然产物。

公开(公告)号：WO2011078544A3

公开(公告)日：2011-06-30

申请号：PCT/KR2010/009141

申请日：2010-12-21

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  CHOI, Myoung Choul ,  KIM, Hyun Sik ,  YOO, Jong Shin

Inventor： CHOI, Myoung Choul ,  KIM, Hyun Sik ,  YOO, Jong Shin

IPC: H01J37/30 ,  H01J49/26

Abstract: An ion injector may include: a first electrode comprising a first region allowing ions to pass; and a second electrode disposed to enclose one end of the first electrode. The second electrode may include: a second region aligned with the first region to allow the ions to pass; and a protruding portion extending along the path of the ions passing through the second region. A mass spectrometer may be configured by disposing the ion injector adjacent to a skimmer.

公开(公告)号：WO2012074234A2

公开(公告)日：2012-06-07

申请号：PCT/KR2011/008866

申请日：2011-11-21

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  CHOI, Myoung Choul ,  PARK, A Leum ,  KIM, Hyun Sik ,  KIM, Seung Yong ,  YOO, Jong Shin

Inventor： CHOI, Myoung Choul ,  PARK, A Leum ,  KIM, Hyun Sik ,  KIM, Seung Yong ,  YOO, Jong Shin

IPC: G01N27/62 ,  H01J49/26

CPC classification number: H01J49/02 ,  H01J49/0027 ,  H01J49/065 ,  H01J49/38

Abstract: A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) includes: an ionization source generating ions; a deceleration lens, on which the ions generated by the ionization source and spatially dispersed are incident, selectively decelerating the incident ions so as to decrease the distance between the ions; and an ion cyclotron resonance cell on which the ions passing through the deceleration lens are incident. By preventing dispersing of ions due to mass difference and converging the ions using the deceleration lens, the mass range that can be measured at one time can be extended. Also, measurement sensitivity can be improved since the ions are effectively introduced to the ICR cell.

Abstract translation: 傅里叶变换离子回旋共振质谱仪（FT-ICR MS）包括：产生离子的电离源; 由离子源产生的并且空间分散的离子入射的减速透镜选择性地使入射离子减速以减小离子之间的距离; 以及通过减速透镜的离子入射到其上的离子回旋共振单元。 通过防止由于质量差导致的离子分散和使用减速透镜会聚离子，可以延长一次可以测量的质量范围。 此外，由于离子被有效地引入ICR单元，所以可以提高测量灵敏度。

公开(公告)号：WO2012053799A1

公开(公告)日：2012-04-26

申请号：PCT/KR2011/007740

申请日：2011-10-18

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  CHOI, Myoung Choul ,  KIM, Hyun Sik ,  KIM, Seung Yong

Inventor： CHOI, Myoung Choul ,  KIM, Hyun Sik ,  KIM, Seung Yong

IPC: G01N27/62 ,  H01L21/265 ,  H05H13/00

CPC classification number: H01J49/38

Abstract: A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) may include: a signal generator generating a sinusoidal, first voltage signal having a DC offset; a voltage amplifier receiving the first voltage signal from the signal generator and generating a second voltage signal by amplifying the first voltage signal; and an ion cyclotron resonance (ICR) trap receiving the second voltage signal and generating an ion cyclotron motion centered on the position determined by the DC offset.

Abstract translation: 傅立叶变换离子回旋共振质谱仪（FT-ICR MS）可以包括：产生具有DC偏移的正弦，第一电压信号的信号发生器; 电压放大器，从信号发生器接收第一电压信号，并通过放大第一电压信号产生第二电压信号; 以及离子回旋共振（ICR）陷阱，其接收第二电压信号并产生以由DC偏移确定的位置为中心的离子回旋加速器运动。

公开(公告)号：WO2011081352A3

公开(公告)日：2011-07-07

申请号：PCT/KR2010/009254

申请日：2010-12-23

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  KANG, Duk Jin ,  CHOI, Myoung Choul ,  YOO, Jong Shin ,  KIM, Hyun Sik

Inventor： KANG, Duk Jin ,  CHOI, Myoung Choul ,  YOO, Jong Shin ,  KIM, Hyun Sik

IPC: G01N27/26 ,  H01J49/04 ,  G01N33/48 ,  G01N33/68

Abstract: An apparatus for electrospray ionization may include: a platform including an inlet port, a first channel connected to the inlet port, a second channel connected to the first channel, and an outlet port connected to the second channel; a nebulizer provided in the first channel and configured to spray inert gas to a sample sprayed into the first channel through the inlet port; and a focusing lens provided in the second channel and configured to focus ions produced from the sprayed sample toward the outlet port.

公开(公告)号：WO2007091754A1

公开(公告)日：2007-08-16

申请号：PCT/KR2006/003618

申请日：2006-09-12

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  KIM, Hyun Sik ,  CHOI, Myoung Choul ,  YOO, Jong Shin

Inventor： KIM, Hyun Sik ,  CHOI, Myoung Choul ,  YOO, Jong Shin

IPC: G01N27/62

CPC classification number: G01N27/62

Abstract: A tandem Fourier transform ion cyclotron resonance mass spectrometer is provided. In the mass spectrometer, the ions selected by a FT-ICR mass analyzer, which can perform an ion selection process and a mass measurement process with a time interval between the processes, are transmitted through an ion guide to a collision cell, which is located a predetermined distance from the FT-ICR mass analyzer, to split into fragment ions. The fragment ions are transmitted to the FT-ICR mass analyzer that measures the mass of the fragment ions. The fragment ions are generated in the collision cell 60 established separately from the FT- ICR mass analyzer 40 according to the mass spectrometer. Accordingly, It can solve various problems (e.g., the radius reduction of cyclotron motion of colliding ions, or the removal of periphery gas after generating the fragment ions) occurred in a tandem mass spectrometer using a conventional tandem-in-time mass analysis method. Also, a high resolution and hith sensitivity measurement can be achieved. Moreover, when a reagent gas instead of a collision gas in the collision cell is injected, the gas phase reaction of the selected ions and the reagent gas can be observed, and the mass of the ions generated in the gas phase reaction can be measured.

Abstract translation: 提供了一种串联傅里叶变换离子回旋共振质谱仪。 在质谱仪中，可以进行离子选择处理的FT-ICR质量分析器选择的离子和在处理之间的时间间隔的质量测量过程通过离子导向器传输到位于 距离FT-ICR质量分析器预定的距离，以分裂为碎片离子。 碎片离子传输到测量碎片离子质量的FT-ICR质量分析仪。 在根据质谱仪与FT-ICR质量分析器40分开设置的碰撞单元60中产生碎片离子。 因此，可以使用常规的串联质量分析方法来解决在串联质谱仪中发生的各种问题（例如，产生碰撞离子的回旋加速器运动的半径减小或产生碎片离子之后的外围气体的去除）。 此外，可以实现高分辨率和高灵敏度测量。 此外，当注入反应气体代替碰撞气体中的碰撞气体时，可以观察到所选择的离子和反应气体的气相反应，并且可以测量在气相反应中产生的离子的质量。

公开(公告)号：EP2519816A2

公开(公告)日：2012-11-07

申请号：EP10841161.2

申请日：2010-12-15

Applicant: Korea Basic Science Institute

Inventor： PARK, Kyu Hwan ,  KIM, Hyun Sik ,  KWON, Kyung Hoon ,  YOO, Jong Shin

IPC: G01N30/72 ,  G01N33/15 ,  B01D15/08

CPC classification number: G01N30/06 ,  G01N30/8686 ,  G01N30/96 ,  G01N33/6848 ,  G01N2030/8809 ,  G01N2030/8813 ,  G01N2500/00 ,  Y10T436/174614 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25375

Abstract: Disclosed is a method for discovering pharmacologically active substances from natural products at high speed, including: obtaining an activity profile by testing pharmacological activity of a plurality of samples; obtaining a mass profile based on a mass spectrum resulting from analysis of the samples by mass spectrometry; and determining molecular weight of pharmacologically active substances by comparing and analyzing the activity profile and the mass profile. The disclosed method allows fast discovery of pharmacologically active substances by performing high resolution mass spectrometry for numerous components included in an extract sample of natural products and comparing with the activity test data. The information about the intensity of the activity of the pharmacologically active substances of the natural products allows effective utilization of the natural products.

公开(公告)号：EP2519816B1

公开(公告)日：2018-10-17

申请号：EP10841161.2

申请日：2010-12-15

Applicant: Korea Basic Science Institute

Inventor： PARK, Kyu Hwan ,  KIM, Hyun Sik ,  KWON, Kyung Hoon ,  YOO, Jong Shin

IPC: G01N30/72 ,  G01N33/15 ,  B01D15/08 ,  G01N30/86 ,  G01N33/68

CPC classification number: G01N30/06 ,  G01N30/8686 ,  G01N30/96 ,  G01N33/6848 ,  G01N2030/8809 ,  G01N2030/8813 ,  G01N2500/00 ,  Y10T436/174614 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25375

Abstract: A method for discovering pharmacologically active substances from natural products at high speed, including: obtaining an activity profile by testing pharmacological activity of a plurality of samples; obtaining mass profiles based on mass spectra resulting from analysis of the samples by mass spectrometry; and determining molecular weight of pharmacologically active substances by comparing and analyzing the activity profile and the mass profile. The method allows fast discovery of pharmacologically active substances by performing high resolution mass spectrometry for numerous components included in an extract sample of natural products and comparing with the activity test data. The information about the intensity of the activity of the pharmacologically active substances of the natural products allows effective utilization of the natural products.

公开(公告)号：EP3147933A2

公开(公告)日：2017-03-29

申请号：EP15875545.4

申请日：2015-12-04

Applicant: Korea Basic Science Institute

Inventor： YANG, Mo ,  KIM, Seung Yong ,  KIM, Hyun Sik ,  JEONG, Wan Seop

IPC: H01J49/40

CPC classification number: H01J49/40 ,  H01J43/10 ,  H01J43/246 ,  H01J49/08 ,  H01J49/142 ,  H01J49/147

Abstract: Provided is a time-of-flight mass spectrometer including: an ionization part receiving electron beams to thereby emit ions; a cold electron supply part injecting the electron beams to the ionization part; an ion detection part detecting the ions emitted from the ionization part; and an ion separation part connecting the ionization part and the ion detection part, wherein the cold electron supply part includes a microchannel plate receiving ultraviolet rays to thereby emit the electron beams, the ions emitted from the ionization part pass through the ion separation part to thereby reach the ion detection part, and the ion separation part has a straight tube shape.

Abstract translation: 提供了一种飞行时间质谱仪，包括：电离部分接收电子束从而发射离子; 向电离部分注入电子束的冷电子供给部; 检测从所述电离部发出的离子的离子检测部; 以及连接电离部和离子检测部的离子分离部，其中，冷电子供给部包括接收紫外线的微通道板，从而发射电子束，从电离部射出的离子通过离子分离部， 到达离子检测部分，离子分离部分具有直管形状。