公开(公告)号：WO2014119892A1

公开(公告)日：2014-08-07

申请号：PCT/KR2014/000767

申请日：2014-01-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： HAM, Jungyeob ,  KIM, Tae Jung ,  KWON, Hak Cheol ,  JEONG, Kyu Hyuk ,  SONG, Jungho ,  CHUNG, Bong Chul

IPC: C07D407/04 ,  C07D307/88 ,  C07D405/04

CPC classification number: C07D307/88 ,  C07D405/04 ,  C07D407/04 ,  C07D409/04 ,  C07D493/04

Abstract: The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.

Abstract translation: 本公开涉及一种制备芳基萘酚化合物的新方法。 在根据本公开的芳基萘木酚素化合物和衍生物的合成中，可以首先构建萘主链，并且可以在最后阶段引入芳基。 通过这种方法，可以有效地合成不能用现有方法准备的各种衍生物。 此外，根据本公开的合成方法适用于大规模生产。

公开(公告)号：WO2009014315A1

公开(公告)日：2009-01-29

申请号：PCT/KR2008/003283

申请日：2008-06-12

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KIM, Su Nam ,  LEE, Woo Jung ,  KWON, Hak Cheol ,  HAM, Jungyeob ,  AHN, Hong Ryul ,  KIM, Myung Soo ,  NAM, Chun-Woo ,  LEE, Jong-Nam ,  LIM, Ju-Sung ,  PARK, Hyun Bong ,  PARK, Yeon-Suk

Inventor： KIM, Su Nam ,  LEE, Woo Jung ,  KWON, Hak Cheol ,  HAM, Jungyeob ,  AHN, Hong Ryul ,  KIM, Myung Soo ,  NAM, Chun-Woo ,  LEE, Jong-Nam ,  LIM, Ju-Sung ,  PARK, Hyun Bong ,  PARK, Yeon-Suk

IPC: A61K36/48 ,  C07C43/00

CPC classification number: A61K36/48 ,  C07C39/21 ,  C07D311/32

Abstract: The present invention relates to a composition containing the extract of Robinia pseudo-acacia var. umbraculifera(Robinia pseudo-acacia var. umbraculifera) , fractions thereof and compounds isolated therefrom as an active ingredient, more precisely a composition containing the extract of Robinia pseudo-acacia var. umbraculifera extracted with water, alcohol or a mixture thereof as a solvent, fractions thereof and compounds isolated therefrom such as amorphastilbol or 5, 7-dihydroxy-6-geranyl flavanone, or its pharmaceutically acceptable salts which can activate peroxisome proliferator-activated receptor (PPAR) to bring the effect of prevention or treatment of obesity, diabetes, inflammation, skin aging, wrinkles. So, the extract of Robinia pseudo-acacia var. umbraculifera , fractions thereof and compounds isolated therefrom of the present invention can be effectively used as an active ingredient for medicines, food and drink or compositions for skin external application.

Abstract translation: 本发明涉及含有刺槐提取物的组合物。 芜菁（Robinia pseudo-acacia var。umbraculifera），其分数和作为活性成分分离的化合物，更确切地说是含有刺槐提取物的组合物。 以水，醇或其作为溶剂的混合物，其馏分和从其分离的化合物如阿莫法星或5,7-二羟基-6-香叶基黄烷酮或其可以活化过氧化物酶体增殖物激活受体（PPAR）的药学上可接受的盐提取 ）带来预防或治疗肥胖，糖尿病，炎症，皮肤老化，皱纹的效果。 所以，刺槐拟提取物 本发明的级分和与其分离的化合物可以有效地用作药物，食品和饮料或外用皮肤组合物的活性成分。

公开(公告)号：EP2854828A1

公开(公告)日：2015-04-08

申请号：EP13794326.2

申请日：2013-05-24

Applicant: Korea Institute of Science and Technology

Inventor： HAM, Jungyeob ,  KANG, Ki Sung ,  CHUNG, Bong Chul ,  KWON, Hak Cheol ,  PARK, Soon Hye ,  CHOI, Pil Ju ,  KIM, Su Nam ,  YANG, Hyun Ok

IPC: A61K36/258 ,  A61K31/704 ,  A61K31/70

CPC classification number: A61K36/258 ,  A61K31/704 ,  A61K2236/37 ,  A61K2300/00

Abstract: Provided are a Panax spp. plant extract including 90% or more of Rg3, Rk1, and Rg5 with respect to a weight of ginsenoside Rb1, Rc, Rb2, Rd, Rg3, Rk1, and Rg5 obtainable by irradiating microwaves to a Panax spp. plant or an extract thereof, a method of preparing the Panax spp. plant extract, and a pharmaceutical composition and a health functional food composition for improving one of the side effects of anticancer drugs such as declining immunity and developing a anticancer drugs resistance, improving antioxidation, anticancer, anti-inflammation, brain function or cognitive function, vasodilation inhibition of platelet aggregation, improving dermatitis, or improving psoriasis.

公开(公告)号：EP3799877A1

公开(公告)日：2021-04-07

申请号：EP20199737.6

申请日：2020-10-02

Applicant: Korea Institute of Science and Technology

Inventor： HAM, Jungyeob ,  KIM, Taejung ,  CHUNG, Bong Chul ,  LEE, Seok ,  SONG, Bong Geun ,  HA, Sungdo ,  Park, Young Tae ,  CHOI, Pilju ,  RYU, Hoon

IPC: A61K36/185 ,  A61K41/00 ,  B01D1/00

Abstract: Provided are: a method of preparing a cannabis processed product having an increased CBD content in an efficient and economic manner, through a decarboxylation reaction by continuous microwave irradiation of a cannabis extract; and use of a processed product having an increased CBD content prepared by the method, a fraction thereof, and a single ingredient of CBD, in foods, drugs, and cosmetics.

公开(公告)号：EP2854828B1

公开(公告)日：2019-08-07

申请号：EP13794326.2

申请日：2013-05-24

Applicant: Korea Institute of Science and Technology

Inventor： HAM, Jungyeob ,  KANG, Ki Sung ,  CHUNG, Bong Chul ,  KWON, Hak Cheol ,  PARK, Soon Hye ,  CHOI, Pil Ju ,  KIM, Su Nam ,  YANG, Hyun Ok

IPC: A61K36/258 ,  A61K31/704 ,  A61K31/70