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1.发明申请
公开(公告)号：WO2014119892A1
公开(公告)日：2014-08-07
申请号：PCT/KR2014/000767
申请日：2014-01-28
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： HAM, Jungyeob , KIM, Tae Jung , KWON, Hak Cheol , JEONG, Kyu Hyuk , SONG, Jungho , CHUNG, Bong Chul
IPC: C07D407/04 , C07D307/88 , C07D405/04
CPC classification number: C07D307/88 , C07D405/04 , C07D407/04 , C07D409/04 , C07D493/04
Abstract: The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.
Abstract translation: 本公开涉及一种制备芳基萘酚化合物的新方法。 在根据本公开的芳基萘木酚素化合物和衍生物的合成中，可以首先构建萘主链，并且可以在最后阶段引入芳基。 通过这种方法，可以有效地合成不能用现有方法准备的各种衍生物。 此外，根据本公开的合成方法适用于大规模生产。
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2.发明申请A COMPOSITION THAT IS COMPRISING EXTRACTS, FRACTIONS OR ISOLATED SINGLE COMPOUNDS OF ROBINIA PSEUDO-ACACIA VAR. UMBRACULIFERA 审中-公开包含罗毕尼亚PSEUDO-ACACIA VAR的提取物，分离物或分离的单一化合物的组合物。 UMBRACULIFERA
公开(公告)号：WO2009014315A1
公开(公告)日：2009-01-29
申请号：PCT/KR2008/003283
申请日：2008-06-12
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , KIM, Su Nam , LEE, Woo Jung , KWON, Hak Cheol , HAM, Jungyeob , AHN, Hong Ryul , KIM, Myung Soo , NAM, Chun-Woo , LEE, Jong-Nam , LIM, Ju-Sung , PARK, Hyun Bong , PARK, Yeon-Suk
Inventor： KIM, Su Nam , LEE, Woo Jung , KWON, Hak Cheol , HAM, Jungyeob , AHN, Hong Ryul , KIM, Myung Soo , NAM, Chun-Woo , LEE, Jong-Nam , LIM, Ju-Sung , PARK, Hyun Bong , PARK, Yeon-Suk
CPC classification number: A61K36/48 , C07C39/21 , C07D311/32
Abstract: The present invention relates to a composition containing the extract of Robinia pseudo-acacia var. umbraculifera(Robinia pseudo-acacia var. umbraculifera) , fractions thereof and compounds isolated therefrom as an active ingredient, more precisely a composition containing the extract of Robinia pseudo-acacia var. umbraculifera extracted with water, alcohol or a mixture thereof as a solvent, fractions thereof and compounds isolated therefrom such as amorphastilbol or 5, 7-dihydroxy-6-geranyl flavanone, or its pharmaceutically acceptable salts which can activate peroxisome proliferator-activated receptor (PPAR) to bring the effect of prevention or treatment of obesity, diabetes, inflammation, skin aging, wrinkles. So, the extract of Robinia pseudo-acacia var. umbraculifera , fractions thereof and compounds isolated therefrom of the present invention can be effectively used as an active ingredient for medicines, food and drink or compositions for skin external application.
Abstract translation: 本发明涉及含有刺槐提取物的组合物。 芜菁（Robinia pseudo-acacia var。umbraculifera），其分数和作为活性成分分离的化合物，更确切地说是含有刺槐提取物的组合物。 以水，醇或其作为溶剂的混合物，其馏分和从其分离的化合物如阿莫法星或5,7-二羟基-6-香叶基黄烷酮或其可以活化过氧化物酶体增殖物激活受体（PPAR）的药学上可接受的盐提取 ）带来预防或治疗肥胖，糖尿病，炎症，皮肤老化，皱纹的效果。 所以，刺槐拟提取物 本发明的级分和与其分离的化合物可以有效地用作药物，食品和饮料或外用皮肤组合物的活性成分。
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3.发明申请METHOD OF PRODUCING COMPOUND HAVING DECREASED SUGAR FROM GLYCOSIDE, EXTRACT, AND PHARMACEUTICAL AND FOOD COMPOSITIONS INCLUDING THE COMPOUND 审中-公开生产由甘氨酸，提取物和药物组成的降解糖的化合物的方法和包括化合物的食品组合物
公开(公告)号：WO2014204104A1
公开(公告)日：2014-12-24
申请号：PCT/KR2014/004593
申请日：2014-05-22
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： HAM, Jung Yeob , KANG, Ki Sung , CHUNG, Bong Chul , KIM, Hee Jin , KWON, Hak Cheol , KIM, Young Joo , CHOI, Pil Ju , LEE, Myeong Jae
IPC: C07H17/07 , C07D311/30 , C07H1/08
CPC classification number: C07H1/08 , C07D311/30 , C07H17/07
Abstract: Provided are a method of producing a compound in which a sugar of a glycoside is reduced or removed, and an extract, a pharmaceutical composition, and a food composition including the compound.
Abstract translation: 提供其中糖苷的糖被还原或除去的化合物的制备方法，以及包含该化合物的提取物，药物组合物和食品组合物。
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4.发明申请PANAX SPP. PLANT EXTRACT WITH INCREASED CONTENT RATIO OF GINSENOSIDE RG3, RG5, AND RK1 PRODUCED BY MICROWAVE IRRADIATION, A METHOD OF PREPARING THE PANAX SPP. PLANT EXTRACT, AND A COMPOSITION INCLUDING THE PANAX SPP. PLANT EXTRACT 审中-公开PANAX SPP。 植物提取物，其具有通过微波辐射产生的茚三烯RG3，RG5和RK1的增加的含量比例，制备PANAX SPP的方法。 植物提取物，以及包括PANAX SPP的组合物。 植物提取物
公开(公告)号：WO2013176512A1
公开(公告)日：2013-11-28
申请号：PCT/KR2013/004562
申请日：2013-05-24
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： HAM, Jung Yeob , KANG, Ki Sung , CHUNG, Bong Chul , KWON, Hak Cheol , PARK, Soon Hye , CHOI, Pil Ju , KIM, Su Nam , YANG, Hyun Ok
IPC: A61K36/258 , A61K31/704 , A61K31/70
CPC classification number: A61K36/258 , A61K31/704 , A61K2236/37 , A61K2300/00
Abstract: Provided are a Panax spp. plant extract including 90% or more of Rg3, Rk1, and Rg5 with respect to a weight of ginsenoside Rb1, Rc, Rb2, Rd, Rg3, Rk1, and Rg5 obtainable by irradiating microwaves to a Panax spp. plant or an extract thereof, a method of preparing the Panax spp. plant extract, and a pharmaceutical composition and a health functional food composition for improving one of the side effects of anticancer drugs such as declining immunity and developing a anticancer drugs resistance, improving antioxidation, anticancer, anti-inflammation, brain function or cognitive function, vasodilation inhibition of platelet aggregation, improving dermatitis, or improving psoriasis.
Abstract translation: 提供的是Panax spp。 相对于通过将微波照射到人参上可获得的人参皂苷Rb1，Rc，Rb2，Rd，Rg3，Rk1和Rg5的重量，Rg3，Rk1和Rg5的植物提取物包含90％以上的植物提取物。 植物或其提取物，制备Panax spp的方法。 植物提取物，以及用于改善抗癌药物的副作用之一的药物组合物和健康功能食品组合物，例如免疫力下降和抗癌药物抗性，改善抗氧化，抗癌，抗炎，脑功能或认知功能，血管扩张 抑制血小板聚集，改善皮炎或改善牛皮癣。
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Patent Agency Ranking5.发明申请THE CO-CULTURE METHOD OF SPHINGOMONAS SP. BACTERIAL STRAIN AND ASPERGILLUS SP. FUNGUS STRAIN, NEW ANTI-CANCER AND ANTIBIOTIC GLIONITRINS DERIVED FROM THIS CO-CULTURE METHOD, AND PHARMACEUTICAL COMPOSITION CONTAINING GLIONITRINS OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS AN ACTIVE INGREDIENT 审中-公开SPHINGOMONAS SP的共培养方法 细菌菌株和ASPERGILLUS SP。 由该共培养方法衍生的新的抗癌和抗生素类药物，以及含有作为活性成分的糖皮质激素或药物可接受的盐的药物组合物
公开(公告)号：WO2009066876A2
公开(公告)日：2009-05-28
申请号：PCT/KR2008/006275
申请日：2008-10-23
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , YANG, Hyun Ok , KWON, Hak Cheol , PARK, Hyun-Bong , YOO, Ji-Hye
Inventor： YANG, Hyun Ok , KWON, Hak Cheol , PARK, Hyun-Bong , YOO, Ji-Hye
IPC: C12N1/20
CPC classification number: C12R1/66 , A23L29/065 , A23L33/10 , A23L33/135 , C12N1/14 , C12N1/20 , C12P17/182 , C12P17/185 , C12P39/00 , C12R1/01
Abstract: The present invention relates to a co-culture method of Sphingomonas sp. bacterial strain and Aspergillus sp. fungus strain, in which the novel Sphingomonas sp. bacterial strain KMK-001 is cultured in a liquid medium and the novel Aspergillus sp. strain KMC-901 separately cultured in another liquid medium is added to the above culture solution, a novel glionitrin biosynthesized therefrom and a pharmaceutical composition comprising the said glionitrin or its pharmaceutically acceptable salt as an active ingredient. The glionitrin herein has strong cytotoxic effect on cancer cells and has antibiotic effect on 10 pathogenic bacteria including the novel Sphingomonas sp. bacterial strain KMK-001, so that it can be effectively applied in antibiotics or anti-cancer agents.
Abstract translation: 本发明涉及鞘氨醇单胞菌（Sphingomonas sp。）的共培养方法。 细菌菌株和曲霉菌属。 真菌菌株，其中新型鞘氨醇单胞菌属 将细菌菌株KMK-001在液体培养基中培养，并将新型曲霉属菌株 在另一种液体培养基中分别培养的菌株KMC-901加入到上述培养液中，由其生物合成新的glionitrin以及包含所述glionitrin或其药学上可接受的盐作为活性成分的药物组合物。 本发明的glionitrin对癌细胞具有强烈的细胞毒性作用，并且对包括新型鞘氨醇单胞菌属在内的10种致病菌具有抗生素作用。 细菌菌株KMK-001，因此可以有效应用于抗生素或抗癌药物。
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公开(公告)号：EP2854828B1
公开(公告)日：2019-08-07
申请号：EP13794326.2
申请日：2013-05-24
Applicant: Korea Institute of Science and Technology
Inventor： HAM, Jungyeob , KANG, Ki Sung , CHUNG, Bong Chul , KWON, Hak Cheol , PARK, Soon Hye , CHOI, Pil Ju , KIM, Su Nam , YANG, Hyun Ok
IPC: A61K36/258 , A61K31/704 , A61K31/70
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7.发明公开THE CO-CULTURE METHOD OF SPHINGOMONAS SP. BACTERIAL STRAIN AND ASPERGILLUS SP. FUNGUS STRAIN, NEW ANTI-CANCER AND ANTIBIOTIC GLIONITRINS DERIVED FROM THIS CO-CULTURE METHOD, AND PHARMACEUTICAL COMPOSITION CONTAINING GLIONITRINS OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS AN ACTIVE INGREDIENT 审中-公开KOKULTURVERFAHREN为细菌菌株鞘氨醇SP。 和蘑菇菌株曲霉，NEW FROM，发达国家KOKULTURVERFAHREN抗癌抗生素GLIONITRINE和药物组合物与GLIONITRINEN或其可接受的盐作为药物一个活动
公开(公告)号：EP2209887A2
公开(公告)日：2010-07-28
申请号：EP08851184.5
申请日：2008-10-23
Applicant: Korea Institute of Science and Technology
Inventor： YANG, Hyun Ok , KWON, Hak Cheol , PARK, Hyun-Bong , YOO, Ji-Hye
IPC: C12N1/20
CPC classification number: C12R1/66 , A23L29/065 , A23L33/10 , A23L33/135 , C12N1/14 , C12N1/20 , C12P17/182 , C12P17/185 , C12P39/00 , C12R1/01
Abstract: The present invention relates to a co-culture method of Sphingomonas sp. bacterial strain and Aspergillus sp. fungus strain, in which the novel Sphingomonas sp. bacterial strain KMK-001 is cultured in a liquid medium and the novel Aspergillus sp. strain KMC-901 separately cultured in another liquid medium is added to the above culture solution, a novel glionitrin biosynthesized therefrom and a pharmaceutical composition comprising the said glionitrin or its pharmaceutically acceptable salt as an active ingredient. The glionitrin herein has strong cytotoxic effect on cancer cells and has antibiotic effect on 10 pathogenic bacteria including the novel Sphingomonas sp. bacterial strain KMK-001, so that it can be effectively applied in antibiotics or anti-cancer agents.
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公开(公告)号：EP4467147A1
公开(公告)日：2024-11-27
申请号：EP23743449.3
申请日：2023-01-18
Applicant: Korea Institute of Science and Technology
Inventor： CHOI, Ki Young , CHA, Kwang-Hyun , HAN, Hwa Seung , PARK, Jin Soo , SONG, Dae-geun , KIM, Myung Suk , KWON, Hak Cheol
IPC: A61K35/74 , A61K35/745 , A61P29/00 , A23L33/135 , A23K10/16 , A61P1/00
Abstract: The present invention relates to a composition for preventing, ameliorating, or treating inflammatory diseases comprising extracellular vesicles (EVs) derived from Roseburia spp. strains and/or Bifidobacterium spp. strains. The EVs of the present invention exhibits effectiveness in improving inflammatory bowel disease (IBD), and additionally, all EVs derived from congeneric strains corresponding to Roseburia spp. strains or Bifidobacterium spp. strains. have been confirmed to exhibit strong anti-inflammatory effect. As such, the strain of the present invention and EVs derived therefrom can be provided as a composition for preventing, ameliorating, or treating a variety of inflammatory diseases.
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9.发明公开PANAX SPP. PLANT EXTRACT WITH INCREASED CONTENT RATIO OF GINSENOSIDE RG3, RG5, AND RK1 PRODUCED BY MICROWAVE IRRADIATION, A METHOD OF PREPARING THE PANAX SPP. PLANT EXTRACT, AND A COMPOSITION INCLUDING THE PANAX SPP. PLANT EXTRACT 审中-公开三七SPP。 随着人参皂苷Rg3，RG5和RK1公司生产的微波辐射方法三七SPP的产量增加内容植物提取物。 植物提取物和成分三七SPP。 植物提取物
公开(公告)号：EP2854828A1
公开(公告)日：2015-04-08
申请号：EP13794326.2
申请日：2013-05-24
Applicant: Korea Institute of Science and Technology
Inventor： HAM, Jungyeob , KANG, Ki Sung , CHUNG, Bong Chul , KWON, Hak Cheol , PARK, Soon Hye , CHOI, Pil Ju , KIM, Su Nam , YANG, Hyun Ok
IPC: A61K36/258 , A61K31/704 , A61K31/70
CPC classification number: A61K36/258 , A61K31/704 , A61K2236/37 , A61K2300/00
Abstract: Provided are a Panax spp. plant extract including 90% or more of Rg3, Rk1, and Rg5 with respect to a weight of ginsenoside Rb1, Rc, Rb2, Rd, Rg3, Rk1, and Rg5 obtainable by irradiating microwaves to a Panax spp. plant or an extract thereof, a method of preparing the Panax spp. plant extract, and a pharmaceutical composition and a health functional food composition for improving one of the side effects of anticancer drugs such as declining immunity and developing a anticancer drugs resistance, improving antioxidation, anticancer, anti-inflammation, brain function or cognitive function, vasodilation inhibition of platelet aggregation, improving dermatitis, or improving psoriasis.
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