公开(公告)号：EP4534528A1

公开(公告)日：2025-04-09

申请号：EP23816418.0

申请日：2023-06-05

Applicant: Korea Institute of Science and Technology

Inventor： PARK, Ki Duk ,  PARK, Jong-Hyun ,  CHOI, Ji Won ,  CHO, Sung Jin ,  KIM, Hyeon Jeong ,  PARK, Sun Jun ,  KIM, Yoowon ,  KIM, Byungeun ,  KIM, Jushin ,  LEE, Elijah Hwejin ,  KIM, Rium ,  KIM, Jaehwan

IPC: C07D213/24 ,  A61K31/44 ,  A61K31/505 ,  A61K31/444 ,  A61K31/5377 ,  A61P1/16 ,  A61P13/12 ,  A61P11/00 ,  A61P25/28 ,  A61P17/06

Abstract: The present invention relates to a sulfanone derivative or a pharmaceutically acceptable salt thereof, and a composition containing the derivative as an active ingredient for the prevention or treatment of cancer, and the sulfanone derivative of the present invention or a pharmaceutically acceptable salt thereof exhibits an excellent effect on Nrf2 activation and a high solubility and pharmaco-metabolic stability, has anti-inflammatory and antioxidant effects, and improves motor performance and cognitive ability, and thus can be used for the prevention or treatment of diseases induced by a decrease in the Nrf2 activity, preferably liver diseases, kidney diseases, lung diseases, neurodegenerative diseases, mitochondrial myopathy, Friedreich's ataxia, corneal endothelial cell loss, psoriasis, and the like.