公开(公告)号：WO2008050932A1

公开(公告)日：2008-05-02

申请号：PCT/KR2006/005350

申请日：2006-12-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KANG, Chong Yun ,  YOON, Seok Jin ,  JEONG, Dae Yong ,  KIM, Hyun Jai ,  VASILJEV, Piotr ,  CHOI, Ji Won

Inventor： KANG, Chong Yun ,  YOON, Seok Jin ,  JEONG, Dae Yong ,  KIM, Hyun Jai ,  VASILJEV, Piotr ,  CHOI, Ji Won

IPC: H02N2/00

CPC classification number: H02N2/026 ,  H02N2/0015

Abstract: The present invention relates to a piezoelectric linear motor that can make relatively low abrasion and accurate linear movement since stationary AC voltages are applied to two piezoelectric elements with a phase difference. The present invention provides a piezoelectric linear motor, comprising: a piezoelectric substrate having a first piezoelectric element and a second piezoelectric element, wherein AC voltages are applied to the first and second piezoelectric elements with a phase difference; a metallic elastic body having first and second elastic bodies coupled to the piezoelectric elements and a central protrusion protruded at the central portion connecting the first and second elastic bodies, wherein the central protrusion oscillates elliptically during an application of the voltage; and a mover brought into contact with the central protrusion of the metallic elastic body for a linear movement, and wherein the movement of the mover is orthogonal to the central protrusion.

Abstract translation: 本发明涉及一种压电线性电动机，其可以使相对低的磨损和精确的线性运动，因为固定的AC电压被施加到具有相位差的两个压电元件。 本发明提供一种压电线性电动机，包括：具有第一压电元件和第二压电元件的压电基板，其中交流电压以相位差施加到第一和第二压电元件; 金属弹性体，其具有联接到所述压电元件的第一和第二弹性体以及在连接所述第一和第二弹性体的中心部分处突出的中心突起，其中所述中心突起在施加所述电压期间椭圆形振荡; 以及与金属弹性体的中心突起接触的动子，用于线性运动，并且其中移动器的运动与中心突起正交。

公开(公告)号：EP4245749A1

公开(公告)日：2023-09-20

申请号：EP21892368.8

申请日：2021-11-12

Applicant: Institute for Basic Science ,  Korea Institute of Science and Technology

Inventor： LEE, Chang Jun ,  CHUN, Heejung ,  WON, Woojin ,  PARK, Ki Duk ,  PARK, Jong Hyun ,  PAE, Ae Nim ,  CHOI, Ji Won ,  LEE, Elijah ,  PARK, Sun Jun ,  KIM, Hyeon Jeong ,  KIM, Yoowon ,  KIM, Byung Eun ,  KIM, Siwon

IPC: C07C211/53 ,  A61K31/136 ,  A61P25/28 ,  A23L33/10 ,  A23L29/00

Abstract: The present invention provides a novel aminoaromatic compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition that is for preventing or treating neurodegenerative diseases and comprises same as an active ingredient, and a health functional food composition for preventing or ameliorating neurodegenerative diseases.

公开(公告)号：EP4534528A1

公开(公告)日：2025-04-09

申请号：EP23816418.0

申请日：2023-06-05

Applicant: Korea Institute of Science and Technology

Inventor： PARK, Ki Duk ,  PARK, Jong-Hyun ,  CHOI, Ji Won ,  CHO, Sung Jin ,  KIM, Hyeon Jeong ,  PARK, Sun Jun ,  KIM, Yoowon ,  KIM, Byungeun ,  KIM, Jushin ,  LEE, Elijah Hwejin ,  KIM, Rium ,  KIM, Jaehwan

IPC: C07D213/24 ,  A61K31/44 ,  A61K31/505 ,  A61K31/444 ,  A61K31/5377 ,  A61P1/16 ,  A61P13/12 ,  A61P11/00 ,  A61P25/28 ,  A61P17/06

Abstract: The present invention relates to a sulfanone derivative or a pharmaceutically acceptable salt thereof, and a composition containing the derivative as an active ingredient for the prevention or treatment of cancer, and the sulfanone derivative of the present invention or a pharmaceutically acceptable salt thereof exhibits an excellent effect on Nrf2 activation and a high solubility and pharmaco-metabolic stability, has anti-inflammatory and antioxidant effects, and improves motor performance and cognitive ability, and thus can be used for the prevention or treatment of diseases induced by a decrease in the Nrf2 activity, preferably liver diseases, kidney diseases, lung diseases, neurodegenerative diseases, mitochondrial myopathy, Friedreich's ataxia, corneal endothelial cell loss, psoriasis, and the like.

公开(公告)号：EP3838896A1

公开(公告)日：2021-06-23

申请号：EP19849176.3

申请日：2019-08-19

Applicant: Korea Institute of Science and Technology

Inventor： PARK, Ki Duk ,  PAE, Ae Nim ,  LIM, Sang Min ,  PARK, Jong Hyun ,  CHOI, Ji Won ,  KIM, Siwon ,  KIM, Hyeon Jeong ,  YEON, Seul Ki

IPC: C07D401/12 ,  A61K31/44 ,  A61K31/496 ,  A61K31/5355 ,  C07D413/12

Abstract: The present invention relates to a novel halo-(3-(phenylsulfonyl)prop-1-enyl)pyridine derivative or a pharmaceutically acceptable salt thereof; a preparation method thereof; and an Nrf2 activator and a pharmaceutical composition for preventing or treating diseases induced by a decrease in Nrf2 activity, both of which comprise the same as an active ingredient.

公开(公告)号：EP3202759A1

公开(公告)日：2017-08-09

申请号：EP15847985.7

申请日：2015-09-24

Applicant: Korea Institute of Science and Technology

Inventor： PARK, Ki Duk ,  LEE, Changjoon Justin ,  KIM, Dong Jin ,  PAE, Ae Nim ,  CHOO, Hyun Ah ,  MIN, Sun Joon ,  KANG, Yong Koo ,  KIM, Yun Kyung ,  SONG, Hyo Jung ,  CHOI, Ji Won ,  NAM, Min Ho ,  HEO, Jun Young ,  YEON, Seul Ki ,  JANG, Bo Ko ,  JU, Eun Ji ,  JO, Seon Mi ,  PARK, Jong-Hyun

IPC: C07C237/20 ,  C07C237/04 ,  C07C231/12 ,  C07C309/04 ,  A61K31/16 ,  A61K31/167

Abstract: The present disclosure relates to an α-aminoamide derivative compound and a pharmaceutical composition containing the same. According to various embodiments of the present disclosure, provided is a therapeutic agent which can overcome the disadvantages of existing drugs used as a MAO-B inhibitor and, specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of the existing drugs which exhibit a therapeutic effect by irreversibly acting via a covalent bond with MAO-B. Particularly, a new compound having superior stability and efficacy compared to the existing reversible MAO-B inhibitors may be provided.

Abstract translation: 本公开涉及α-氨基酰胺衍生物化合物和含有其的药物组合物。 根据本公开的各种实施方式，提供了一种治疗剂，其可以克服现有药物用作MAO-B抑制剂的缺点，并且具体地通过非共价键可逆地抑制MAO-B，从而缓解或消除 现有药物通过与MAO-B通过共价键发挥不可逆作用而表现出治疗效果的副作用。 特别地，可以提供与现有可逆MAO-B抑制剂相比具有优良稳定性和功效的新化合物。