公开(公告)号：DK2654793T3

公开(公告)日：2017-12-18

申请号：DK11852145

申请日：2011-12-21

Applicant: LEIDOS INC

Inventor： DRESIOS JOHN ,  GRIFFEY RICHARD

IPC: G01N33/50 ,  G01N33/567

公开(公告)号：AU2019299339A1

公开(公告)日：2021-01-21

申请号：AU2019299339

申请日：2019-07-01

Applicant: LEIDOS INC

Inventor： CHAPPELL STEPHEN A ,  MAURO VINCENT P ,  DRESIOS JOHN

IPC: C12P21/00 ,  C07H21/04 ,  C12N15/00 ,  C12P21/04 ,  C12P21/06 ,  C12Q1/68

Abstract: The present disclosure provides materials and methods for cell-free expression of epitopes for immunotherapy applications. In particular, the present disclosure provides materials and methods for expressing concatenated epitopes using a cell-free protein synthesis platform for high throughput, large scale, and unbiased epitope screening and the generation of multi-epitope vaccines.

公开(公告)号：CA3104859A1

公开(公告)日：2020-01-09

申请号：CA3104859

申请日：2019-07-01

Applicant: LEIDOS INC

Inventor： CHAPPELL STEPHEN A ,  MAURO VINCENT P ,  DRESIOS JOHN

IPC: C12P21/00 ,  C07H21/04 ,  C12N15/00 ,  C12P21/04 ,  C12P21/06 ,  C12Q1/68

Abstract: The present disclosure provides materials and methods for cell-free expression of epitopes for immunotherapy applications. In particular, the present disclosure provides materials and methods for expressing concatenated epitopes using a cell-free protein synthesis platform for high throughput, large scale, and unbiased epitope screening and the generation of multi-epitope vaccines.

公开(公告)号：EP2654793A4

公开(公告)日：2015-07-22

申请号：EP11852145

申请日：2011-12-21

Applicant: LEIDOS INC

Inventor： DRESIOS JOHN ,  GRIFFEY RICHARD

IPC: A61K39/44 ,  G01N33/50 ,  G01N33/567

CPC classification number: G01N33/6887 ,  A61K9/1271 ,  A61K38/02 ,  A61K38/1777 ,  A61K39/44 ,  A61K47/42 ,  A61K47/48376 ,  A61K47/48384 ,  A61K47/48415 ,  A61K47/48553 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6847 ,  A61K49/0058 ,  C07K16/18 ,  G01N33/5088 ,  G01N33/567 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4712 ,  G01N2333/78

Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.

Abstract translation: 本公开涉及用于鉴定特异性暴露于伤口部位的细胞内，细胞外或细胞外基质蛋白的蛋白质或肽基序的方法，以及用于治疗伤口的组合物及其使用方法。