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    Microchip electrophoresis inkjet dispensing
    1.
    发明专利
    Microchip electrophoresis inkjet dispensing 未知

    公开(公告)号：AU2017311109A1

    公开(公告)日：2019-02-21

    申请号：AU2017311109

    申请日：2017-08-07

    Applicant: LI COR INC

    Inventor： FURTAW MICHAEL D ,  LAMB DONALD T

    IPC: G01N27/447

    Abstract: Devices and methods are provided for the separation and dispensing of material using a microfluidic electrophoresis column, sheath liquid pump, and exit channel, all on the same monolithic chip. Material is separated in the electrophoresis column and passed into the exit chamber in response to a voltage potential between a first electrode within the electrophoresis column and a terminating electrode integrated into the chip. The terminating electrode can be in the sheath liquid pump chamber, the sheath liquid reservoir, or a separate flow channel that intersects the exit channel along with the electrophoresis column and sheath liquid pump chamber. The flow of sheath liquid into the exit chamber entrains separated analytes into an effluent that is dispensed out of the exit chamber via a discharge outlet.

    Capillary electrophoresis inkjet dispensing
    2.
    发明专利
    Capillary electrophoresis inkjet dispensing 未知

    公开(公告)号：AU2017213725A1

    公开(公告)日：2018-08-09

    申请号：AU2017213725

    申请日：2017-01-30

    Applicant: LI COR INC

    Inventor： FURTAW MICHAEL D ,  LAMB DONALD T

    IPC: H01J49/04 ,  B01D57/02 ,  G01N27/26 ,  G01N27/447 ,  H01J49/16

    Abstract: Devices, systems, and methods of using them are disclosed that position an end of a capillary electrophoresis tube within an internal tapered nozzle region of an inkjet print head or other microfluidic pump. The capillary electrophoresis tube can extend through an inlet of the microfluidic pump and leave space for a sheath liquid to enter the pump and mix with separated analytes eluted from the capillary electrophoresis tube. The small volume of mixed sheath liquid and analyte can then be jetted through the nozzle at a moving surface, either continuously or as discrete droplets. Relative positions on the surface can indicate separation distances of dispensed analytes.

    MULTI-SHEATH FLOW AND ON-CHIP TERMINATING ELECTRODE FOR MICROFLUIDIC DIRECT-BLOTTING
    6.
    发明专利
    MULTI-SHEATH FLOW AND ON-CHIP TERMINATING ELECTRODE FOR MICROFLUIDIC DIRECT-BLOTTING 未知

    公开(公告)号：CA3031226A1

    公开(公告)日：2018-02-15

    申请号：CA3031226

    申请日：2017-08-07

    Applicant: LI COR INC

    Inventor： FURTAW MICHAEL D ,  LAMB DONALD T ,  MIDDENDORF LYLE R

    IPC: G01N27/447 ,  B01L3/00 ,  G01N30/72

    Abstract: Devices and methods are provided for the separation and dispensing of material using a microfluidic separation column connected via an exit channel to one or more sheath flow channels. The flow of separated material through the separation column is at least partially driven by a voltage potential between a first electrode within the separation column and a terminating electrode within at least one of the sheath flow channels. The separation column, exit channel, sheath flow channels, and electrodes are all within a single monolithic chip. The presence of an on-chip terminating electrode allows for separated material to be entrained in the sheath fluids and ejected onto a surface that can be non-conductive. The presence of multiple sheath flows allows for sheath flow fluids to have different compositions from one another, while reducing the occurrence of sheath flow fluids entering the separation column.

    MICROCHIP ELECTROPHORESIS INKJET DISPENSING
    7.
    发明专利
    MICROCHIP ELECTROPHORESIS INKJET DISPENSING 未知

    公开(公告)号：CA3031212A1

    公开(公告)日：2018-02-15

    申请号：CA3031212

    申请日：2017-08-07

    Applicant: LI COR INC

    Inventor： FURTAW MICHAEL D ,  LAMB DONALD T

    IPC: G01N27/447

    Abstract: Devices and methods are provided for the separation and dispensing of material using a microfluidic electrophoresis column, sheath liquid pump, and exit channel, all on the same monolithic chip. Material is separated in the electrophoresis column and passed into the exit chamber in response to a voltage potential between a first electrode within the electrophoresis column and a terminating electrode integrated into the chip. The terminating electrode can be in the sheath liquid pump chamber, the sheath liquid reservoir, or a separate flow channel that intersects the exit channel along with the electrophoresis column and sheath liquid pump chamber. The flow of sheath liquid into the exit chamber entrains separated analytes into an effluent that is dispensed out of the exit chamber via a discharge outlet.

    Microchip electrophoresis inkjet dispensing
    9.
    发明专利
    Microchip electrophoresis inkjet dispensing 未知

    公开(公告)号：AU2017311109B2

    公开(公告)日：2021-01-28

    申请号：AU2017311109

    申请日：2017-08-07

    Applicant: LI COR INC

    Inventor： FURTAW MICHAEL D ,  LAMB DONALD T

    IPC: G01N27/447

    Abstract: Devices and methods are provided for the separation and dispensing of material using a microfluidic electrophoresis column, sheath liquid pump, and exit channel, all on the same monolithic chip. Material is separated in the electrophoresis column and passed into the exit chamber in response to a voltage potential between a first electrode within the electrophoresis column and a terminating electrode integrated into the chip. The terminating electrode can be in the sheath liquid pump chamber, the sheath liquid reservoir, or a separate flow channel that intersects the exit channel along with the electrophoresis column and sheath liquid pump chamber. The flow of sheath liquid into the exit chamber entrains separated analytes into an effluent that is dispensed out of the exit chamber via a discharge outlet.

    Multi-sheath flow and on-chip terminating electrode for microfluidic direct-blotting
    10.
    发明专利
    Multi-sheath flow and on-chip terminating electrode for microfluidic direct-blotting 未知

    公开(公告)号：AU2017311105A1

    公开(公告)日：2019-02-21

    申请号：AU2017311105

    申请日：2017-08-07

    Applicant: LI COR INC

    Inventor： FURTAW MICHAEL D ,  LAMB DONALD T ,  MIDDENDORF LYLE R

    IPC: G01N27/447 ,  B01L3/00 ,  G01N30/72

    Abstract: Devices and methods are provided for the separation and dispensing of material using a microfluidic separation column connected via an exit channel to one or more sheath flow channels. The flow of separated material through the separation column is at least partially driven by a voltage potential between a first electrode within the separation column and a terminating electrode within at least one of the sheath flow channels. The separation column, exit channel, sheath flow channels, and electrodes are all within a single monolithic chip. The presence of an on-chip terminating electrode allows for separated material to be entrained in the sheath fluids and ejected onto a surface that can be non-conductive. The presence of multiple sheath flows allows for sheath flow fluids to have different compositions from one another, while reducing the occurrence of sheath flow fluids entering the separation column.

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