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    MULTI-SHEATH FLOW AND ON-CHIP TERMINATING ELECTRODE FOR MICROFLUIDIC DIRECT-BLOTTING
    4.
    发明专利
    MULTI-SHEATH FLOW AND ON-CHIP TERMINATING ELECTRODE FOR MICROFLUIDIC DIRECT-BLOTTING 未知

    公开(公告)号：CA3031226A1

    公开(公告)日：2018-02-15

    申请号：CA3031226

    申请日：2017-08-07

    Applicant: LI COR INC

    Inventor： FURTAW MICHAEL D ,  LAMB DONALD T ,  MIDDENDORF LYLE R

    IPC: G01N27/447 ,  B01L3/00 ,  G01N30/72

    Abstract: Devices and methods are provided for the separation and dispensing of material using a microfluidic separation column connected via an exit channel to one or more sheath flow channels. The flow of separated material through the separation column is at least partially driven by a voltage potential between a first electrode within the separation column and a terminating electrode within at least one of the sheath flow channels. The separation column, exit channel, sheath flow channels, and electrodes are all within a single monolithic chip. The presence of an on-chip terminating electrode allows for separated material to be entrained in the sheath fluids and ejected onto a surface that can be non-conductive. The presence of multiple sheath flows allows for sheath flow fluids to have different compositions from one another, while reducing the occurrence of sheath flow fluids entering the separation column.

    SPECTRORADIOMETER AND SPECTROPHOTOMETER
    5.
    发明专利
    SPECTRORADIOMETER AND SPECTROPHOTOMETER 未知

    公开(公告)号：CA1210958A

    公开(公告)日：1986-09-09

    申请号：CA435707

    申请日：1983-08-30

    Applicant: LI COR INC

    Inventor： WURM JOHN H ,  BIGGS WILLIAM W ,  MIDDENDORF LYLE R

    IPC: G01J3/00 ,  G01J3/06 ,  G01J3/18 ,  G01J3/28 ,  G01J5/30

    Abstract: SPECTRORADIOMETER AND SPECTROPHOTOMETER To provide sufficient sensitivity, spectral resolution and speed of measurement for field environmental measurements in a portable spectroradiometer, a silicon photodiode receives light: (1) having a bandwidth in the range of between 2 and 15 nm (nanometers) from a pivotable concave holographic diffraction grating within the wavelength range of between 250 and 1150 nm at a scanning rate in the range of 20 to 100 nm per second; (2) having stray light of high intensity and undesired frequencies and the shorter wavelength harmonics of the selected frequency range blocked by filters; and (3) having flux of at least 10 microwatts per square meter of diffuser plate for each nanometer of bandwidth. Automatic electrical zeroing is obtained by blocking all light once at the beginning of each scan, obtaining an electrical drift-related signal and using the drift signal to adjust the measured signal during the scan. Several different sensing interfaces can be used, including a quartz, light fiber probe having at least a 50% packing density and a cone angle of at least 24 degrees. The data and the programming storage is at least 30K bytes but the instrument uses no more than two watts of power when the instrument is not scanning.

    Multi-sheath flow and on-chip terminating electrode for microfluidic direct-blotting
    6.
    发明专利
    Multi-sheath flow and on-chip terminating electrode for microfluidic direct-blotting 未知

    公开(公告)号：AU2017311105A1

    公开(公告)日：2019-02-21

    申请号：AU2017311105

    申请日：2017-08-07

    Applicant: LI COR INC

    Inventor： FURTAW MICHAEL D ,  LAMB DONALD T ,  MIDDENDORF LYLE R

    IPC: G01N27/447 ,  B01L3/00 ,  G01N30/72

    Abstract: Devices and methods are provided for the separation and dispensing of material using a microfluidic separation column connected via an exit channel to one or more sheath flow channels. The flow of separated material through the separation column is at least partially driven by a voltage potential between a first electrode within the separation column and a terminating electrode within at least one of the sheath flow channels. The separation column, exit channel, sheath flow channels, and electrodes are all within a single monolithic chip. The presence of an on-chip terminating electrode allows for separated material to be entrained in the sheath fluids and ejected onto a surface that can be non-conductive. The presence of multiple sheath flows allows for sheath flow fluids to have different compositions from one another, while reducing the occurrence of sheath flow fluids entering the separation column.

    FLUORESCENCE FILTERING SYSTEM AND METHOD FOR MOLECULAR IMAGING
    8.
    发明专利
    FLUORESCENCE FILTERING SYSTEM AND METHOD FOR MOLECULAR IMAGING 未知

    公开(公告)号：CA2724574A1

    公开(公告)日：2009-11-26

    申请号：CA2724574

    申请日：2009-05-13

    Applicant: LI COR INC

    Inventor： BOUZID AHMED ,  LAMB DONALD T ,  RAGATZ ANDREW G ,  MIDDENDORF LYLE R

    IPC: F21V5/00 ,  F21S8/00 ,  G01J1/58

    Abstract: An optical system is disclosed that can be used for fluorescence filtering for molecular imaging. In one preferred embodiment, a source subsystem is disclosed comprising a light source and a first set of filters designed to pass wavelengths of light in an absorption band of a fluorescent material. A detector subsystem is also disclosed comprising a light detector, imaging optics, a second set of filters designed to pass wavelengths of light in an emission band of the fluorescent material, and an aperture located at a front focal plane of the imaging optics. A telecentric space is created between the light detector and the imaging optics, such that axial rays from a plurality of field points emerge from the imaging optics parallel to each other and perpendicular to the second set of filters

    FLUORESCENCE FILTERING SYSTEM AND METHOD FOR MOLECULAR IMAGING
    10.
    发明申请
    FLUORESCENCE FILTERING SYSTEM AND METHOD FOR MOLECULAR IMAGING 审中-公开
    荧光过滤系统和分子成像方法

    公开(公告)号：WO2009142976A3

    公开(公告)日：2010-01-07

    申请号：PCT/US2009043781

    申请日：2009-05-13

    Applicant: LI COR INC ,  BOUZID AHMED ,  LAMB DONALD T ,  RAGATZ ANDREW G ,  MIDDENDORF LYLE R

    Inventor： BOUZID AHMED ,  LAMB DONALD T ,  RAGATZ ANDREW G ,  MIDDENDORF LYLE R

    IPC: F21V5/00

    CPC classification number: G01J3/10 ,  A61B5/0071 ,  G01J3/0208 ,  G01J3/12 ,  G01J3/4406 ,  G01J2003/104 ,  G01J2003/1213 ,  G01J2003/1226 ,  G01N21/6456

    Abstract: An optical system is disclosed that can be used for fluorescence filtering for molecular imaging. In one preferred embodiment, a source subsystem is disclosed comprising a light source and a first set of filters designed to pass wavelengths of light in an absorption band of a fluorescent material. A detector subsystem is also disclosed comprising a light detector, imaging optics, a second set of filters designed to pass wavelengths of light in an emission band of the fluorescent material, and an aperture located at a front focal plane of the imaging optics. A telecentric space is created between the light detector and the imaging optics, such that axial rays from a plurality of field points emerge from the imaging optics parallel to each other and perpendicular to the second set of filters.

    Abstract translation: 公开了可用于分子成像的荧光过滤的光学系统。 在一个优选实施例中，公开了一种源子系统，其包括光源和被设计为通过荧光材料的吸收带中的光的波长的第一组滤光器。 还公开了一种检测器子系统，其包括光检测器，成像光学器件，被设计为通过荧光材料的发射带中的光的波长的第二组滤光器，以及位于成像光学器件的前焦平面处的孔。 在光检测器和成像光学器件之间产生远心空间，使得来自多个场点的轴向射线从成像光学器件彼此平行并垂直于第二组滤光器出射。

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