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    METHODS AND SYSTEMS FOR DETECTING VARIATIONS IN NUCLEIC ACID SEQUENCES
    2.
    发明申请
    METHODS AND SYSTEMS FOR DETECTING VARIATIONS IN NUCLEIC ACID SEQUENCES 审中-公开
    用于检测核酸序列变异的方法和系统

    公开(公告)号：WO2016168713A1

    公开(公告)日：2016-10-20

    申请号：PCT/US2016/027908

    申请日：2016-04-15

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： DENNY, David ,  WOO, David ,  ALIMINATI, Manjula ,  SAMSANI, Siva Kumar ,  SCHNEIDER, Stephanie ,  LIM, Yoke Peng ,  CHANG, Sylvia

    IPC: G06F19/22

    CPC classification number: G01N27/44717 ,  G06F19/22

    Abstract: In one exemplary embodiment, a method for detecting variants in electropherogram data is provided. The method includes receiving electropherogram data from an instrument and analyzing the electropherogram data to identify mixed bases in the electropherogram data. The method further includes identifying features within the electropherogram data indicative of errors and validating the identified mixed bases. Then the method includes determining variants in the electropherogram data based on the validated mixed bases.

    Abstract translation: 在一个示例性实施例中，提供了一种用于检测电泳图数据中的变体的方法。 该方法包括从仪器接收电泳图数据，并分析电泳图数据以识别电泳图数据中的混合碱基。 该方法还包括识别电泳图中指示错误并验证所识别的混合碱基的特征。 然后该方法包括基于经验证的混合碱基来确定电泳图数据中的变体。

    IMAGE DRIVEN QUALITY CONTROL FOR ARRAY BASED PCR
    3.
    发明申请
    IMAGE DRIVEN QUALITY CONTROL FOR ARRAY BASED PCR 审中-公开

    公开(公告)号：WO2020047288A1

    公开(公告)日：2020-03-05

    申请号：PCT/US2019/048862

    申请日：2019-08-29

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： CHU, Yong ,  MAJUMBAR, Nivedita ,  ALIMINATI, Manjula ,  CHEN, Yongzhi ,  PAPENFUSS, Kevin

    IPC: G06N3/04 ,  G06N3/08 ,  G01N35/00 ,  G01N35/02 ,  G06T7/00

    Abstract: A system and methods are provided for image driven quality control for array based PCR. The system comprises a PCR unit, a reaction array plate, a convolutional neural network (CNN) configured to receive a sequence of images of the reaction array plate in the PCR system, and an output of the CNN coupled to a control for the reaction array plate. The method comprises applying a sequence of images from a plurality of subarrays of the reaction array plate to a plurality of CNNs during operation of the PCR system on the reaction plate array, operating the CNNs to generate failure mode predictions for the reaction plate based on the sequence of images, and coupling an output of the CNNs to one or more of a setting for manufacture of the reaction array plate or to control the PCR system.

    METHODS AND SYSTEMS FOR VISUALIZING AND EVALUATING DATA
    4.
    发明申请
    METHODS AND SYSTEMS FOR VISUALIZING AND EVALUATING DATA 审中-公开
    用于可视化和评估数据的方法和系统

    公开(公告)号：WO2013049443A1

    公开(公告)日：2013-04-04

    申请号：PCT/US2012/057716

    申请日：2012-09-28

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： JANAWAY, Gordon ,  ALIMINATI, Manjula ,  WU, Ruoyun ,  FORTESCUE, David ,  SHEN, Ming

    IPC: C12Q1/68

    CPC classification number: G06F19/24 ,  C12Q1/6851 ,  C12Q2537/165 ,  C12Q2563/159

    Abstract: A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time during an amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data. A dPCR result is generated based on the positive or negative amplification determinations for the plurality of samples.

    Abstract translation: 提供了产生数字聚合酶链反应（dPCR）结果的计算机实现的方法。 该方法包括在放大期间的第一时间，从多个样本中检测出第一组发射数据，每个采样包括多个采样区域的样本区域。 该方法还包括部分地基于第一组发射数据确定多个样本中的每个样本的正或负放大确定。 基于多个样本的正或负放大确定产生dPCR结果。

    METHODS AND SYSTEMS FOR VISUALIZING AND EVALUATING DATA
    9.
    发明公开
    METHODS AND SYSTEMS FOR VISUALIZING AND EVALUATING DATA 有权
    VERFAHREN UND SYSTEME ZUR VISUALISIERUNG UND AUSWERTUNG VON DATEN

    公开(公告)号：EP2761027A1

    公开(公告)日：2014-08-06

    申请号：EP12784368.8

    申请日：2012-09-28

    Applicant: Life Technologies Corporation

    Inventor： JANAWAY, Gordon ,  ALIMINATI, Manjula ,  WU, Ruoyun ,  FORTESCUE, David ,  SHEN, Ming

    IPC: C12Q1/68

    CPC classification number: G06F19/24 ,  C12Q1/6851 ,  C12Q2537/165 ,  C12Q2563/159

    Abstract: A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time during an amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data. A dPCR result is generated based on the positive or negative amplification determinations for the plurality of samples.

    Abstract translation: 提供了一种计算机实现的产生数字聚合酶链反应（dPCR）结果的方法。 该方法包括在放大期间的第一时间，从多个样本中检测出第一组发射数据，每个样本包括多个采样区域的采样区域。 该方法还包括部分地基于第一组发射数据来确定多个样本中的每个样本的正或负放大确定。 基于多个样本的正或负放大确定产生dPCR结果。

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