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公开(公告)号：WO2012031263A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/050426
申请日：2011-09-02
Applicant: LIFE TECHNOLOGIES CORPORATION , CAMPBELL, Andrew , CHASE, Lucas , VEMURI, Mohanachari
Inventor： CAMPBELL, Andrew , CHASE, Lucas , VEMURI, Mohanachari
IPC: C12N5/02
CPC classification number: C12N5/0663 , A61K35/12 , C12M25/16 , C12N2500/90 , C12N2500/98 , C12N2511/00 , C12N2531/00 , C12N2533/00
Abstract: The present invention relates to growing stem cells, for e.g., MSCs, in large - scale under GMP-compliance, using media and reagents that satisfy GMP requirements, while maintaining stemness, for effective downstream therapeutic use, which include but are not limited to, stem cell therapy, production of products, such as beneficial factors, recombinant proteins, etc. obtained from such stem cells.
Abstract translation: 本发明涉及使用满足GMP要求的介质和试剂，同时保持干度，有效地下游治疗用途，在例如MSC的大规模GMP顺应性下生长干细胞，例如MSC， 其中包括但不限于干细胞治疗，从这些干细胞获得的产物（例如有益因子，重组蛋白等）的产生。
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Patent Agency Ranking
公开(公告)号：WO2017106783A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/067374
申请日：2016-12-16
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： PHELPS, Mwita , GULDE, Paul , FIKE, Richard , REYNOLDS, Mary , HASSETT, Richard , CAMPBELL, Andrew
CPC classification number: C12N5/0018 , B01J8/1845 , C12N1/22 , C12N2500/32 , C12N2500/34 , C12N2500/60
Abstract: The present invention is directed generally to dry cell culture media or feeds in pellet formats which can be reconstituted into liquid media for culturing cells in vitro. Each pellet composition may comprise the same or a different composition; for example, different vitamins, amino acids, buffers, trace salts, pH, iron chelators, etc. The invention also relates to methods of making dry cell culture media by altering ratios of different pellet compositions, or, methods of making modular dry cell culture media, or customizing media formulations for growing a cell type using pellets. According to the invention, media pellets may be easier to handle either before reconstitution, during shipping and handling; and/or during reconstitution. Media pellets may be used in any container like bags including sterile, single use bags for preparing media formulations. The invention also relates to kits and culture systems using media pellets.
Abstract translation: 本发明总体上涉及干细胞培养基或颗粒形式的饲料，其可以重构成液体培养基用于体外培养细胞。 每种丸粒组合物可以包含相同或不同的组合物; 例如不同的维生素，氨基酸，缓冲剂，微量盐，pH，铁螯合剂等。本发明还涉及通过改变不同丸粒组合物的比例来制备干细胞培养基的方法，或制备模块化干细胞培养物 培养基或使用颗粒定制培养细胞类型的培养基配方。 根据本发明，介质丸粒在重构之前，运输和处理过程中可能更容易处理; 和/或在重建期间。 培养基颗粒可用于任何容器中，如袋子，包括用于制备培养基制剂的无菌一次性袋子。 本发明还涉及使用培养基颗粒的试剂盒和培养系统。
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公开(公告)号：EP2611452B1
公开(公告)日：2018-10-24
申请号：EP11758028.2
申请日：2011-09-02
Applicant: Life Technologies Corporation
Inventor： CAMPBELL, Andrew , CHASE, Lucas , VEMURI, Mohanachari
IPC: C12N5/0775 , A61K35/28 , C12M1/12
CPC classification number: C12N5/0663 , A61K35/12 , C12M25/16 , C12N2500/90 , C12N2500/98 , C12N2511/00 , C12N2531/00 , C12N2533/00
Abstract: The present invention relates to growing stem cells, for e.g., MSCs, in large-scale under GMP-compliance, using media and reagents that satisfy GMP requirements, while maintaining stemness, for effective downstream therapeutic use, which include but are not limited to, stem cell therapy, production of products, such as beneficial factors, recombinant proteins, etc. obtained from such stem cells.
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4.发明公开CELL CULTURE SYSTEM FOR BIOREACTOR SCALE-UP OF CELLS 审中-公开ZELLKULTURSYSTEMFÜRBIOREAKTORAUFSKALIERUNG VON ZELLEN
公开(公告)号：EP2611452A2
公开(公告)日：2013-07-10
申请号：EP11758028.2
申请日：2011-09-02
Applicant: Life Technologies Corporation
Inventor： CAMPBELL, Andrew , CHASE, Lucas , VEMURI, Mohanachari
IPC: A61K35/28 , C12N5/0775
CPC classification number: C12N5/0663 , A61K35/12 , C12M25/16 , C12N2500/90 , C12N2500/98 , C12N2511/00 , C12N2531/00 , C12N2533/00
Abstract: The present invention relates to growing stem cells, for e.g., MSCs, in large-scale under GMP-compliance, using media and reagents that satisfy GMP requirements, while maintaining stemness, for effective downstream therapeutic use, which include but are not limited to, stem cell therapy, production of products, such as beneficial factors, recombinant proteins, etc. obtained from such stem cells.
Abstract translation: 本发明涉及使用满足GMP要求的培养基和试剂，同时保持有效的下游治疗用途的有效的下游治疗用途，例如大规模生长的MSC，例如MSC，其包括但不限于， 干细胞治疗，从这些干细胞获得的产物，例如有益因子，重组蛋白质等。
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公开(公告)号：EP4036220A1
公开(公告)日：2022-08-03
申请号：EP21212458.0
申请日：2016-12-16
Applicant: Life Technologies Corporation
Inventor： PHELPS, Mwita , GULDE, Paul , FIKE, Richard , REYNOLDS, Mary , HASSETT, Richard , CAMPBELL, Andrew
Abstract: The present invention is directed generally to dry cell culture media or feeds in pellet formats which can be reconstituted into liquid media for culturing cells in vitro. Each pellet composition may comprise the same or a different composition; for ex-ample, different vitamins, amino acids, buffers, trace salts, pH, iron chelators, etc. The invention also relates to methods of making dry cell culture media by altering ratios of different pellet compositions, or, methods of making modular dry cell culture media, or customizing media formulations for growing a cell type using pellets. According to the invention, media pellets may be easier to handle either before reconstitution, during shipping and handling; and/or during reconstitution. Media pellets may be used in any container like bags including sterile, single use bags for preparing media formulations. The invention also relates to kits and culture systems using media pellets.
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公开(公告)号：EP3271452A1
公开(公告)日：2018-01-24
申请号：EP16822591.0
申请日：2016-12-16
Applicant: Life Technologies Corporation
Inventor： PHELPS, Mwita , GULDE, Paul , FIKE, Richard , REYNOLDS, Mary , HASSETT, Richard , CAMPBELL, Andrew
CPC classification number: C12N5/0018 , B01J8/1845 , C12N1/22 , C12N2500/32 , C12N2500/34 , C12N2500/60
Abstract: The present invention is directed generally to dry cell culture media or feeds in pellet formats which can be reconstituted into liquid media for culturing cells in vitro. Each pellet composition may comprise the same or a different composition; for example, different vitamins, amino acids, buffers, trace salts, pH, iron chelators, etc. The invention also relates to methods of making dry cell culture media by altering ratios of different pellet compositions, or, methods of making modular dry cell culture media, or customizing media formulations for growing a cell type using pellets. According to the invention, media pellets may be easier to handle either before reconstitution, during shipping and handling; and/or during reconstitution. Media pellets may be used in any container like bags including sterile, single use bags for preparing media formulations. The invention also relates to kits and culture systems using media pellets.
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