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公开(公告)号：WO2023039598A1
公开(公告)日：2023-03-16
申请号：PCT/US2022/076352
申请日：2022-09-13
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： CHESNUT, Jonathan , IHLAN, Alicia , POTTER, Robert , SONG, Youngzee
Abstract: The present disclosure relates to recombinant nucleases, recombinant nucleases operatively linked to nucleic acid binding domains, and methods of making and using them.
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2.发明申请TAL-EFFECTOR ASSEMBLY PLATFORM, CUSTOMIZED SERVICES, KITS AND ASSAYS 审中-公开TAL-EFFECTOR组装平台，定制服务，套件和测试
公开(公告)号：WO2013152220A2
公开(公告)日：2013-10-10
申请号：PCT/US2013/035316
申请日：2013-04-04
Applicant: LIFE TECHNOLOGIES CORPORATION , GENEART AG
Inventor： KATZEN, Federico , CHESNUT, Jonathan , NOTKA, Frank , ARNOLD, Matthias , HOFF, Kevin , WHITESIDE, Stephen
IPC: C12N15/10
CPC classification number: C12N15/1082 , C07K14/195 , C12N9/90 , C12N9/96 , C12N15/102 , C12N15/1086 , C12N15/1093 , C12N15/66 , C12Y599/01002
Abstract: The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.
Abstract translation: 本发明一般涉及用于设计和产生功能性DNA结合效应分子和相关定制服务，工具包和功能测定的组合物和方法。 在一些方面，本发明提供了用于有效组装定制的TAL效应分子的方法和工具。 此外，本发明涉及TAL效应分子的用途和通过例如定制测定法对这种TAL的功能评估。
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公开(公告)号：WO2016065364A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/057401
申请日：2015-10-26
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： POTTER, Robert , CHESNUT, Jonathan , LIANG, Xiquan
CPC classification number: C12N9/22 , C07K2319/00 , C07K2319/81 , C12N15/902 , C12N2310/20
Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.
Abstract translation: 本公开一般涉及用于提高同源重组效率的组合物和方法。 特别地，本公开涉及试剂和这些试剂的用途。
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Patent Agency Ranking
公开(公告)号：WO2011071476A2
公开(公告)日：2011-06-16
申请号：PCT/US2009/064488
申请日：2009-11-13
Applicant: LIFE TECHNOLOGIES CORPORATION , LAKSHMIPATHY, Uma , THYAGARAJAN, Bhaskar , CHESNUT, Jonathan , ANEST, Vasiliki , BENNETT, Robert , LIEU, Pauline , HANSON, George , THOMPSON, David , CHASE, Lucas , SHIPLEY, Gary , WILSON, Elizabeth
Inventor： LAKSHMIPATHY, Uma , THYAGARAJAN, Bhaskar , CHESNUT, Jonathan , ANEST, Vasiliki , BENNETT, Robert , LIEU, Pauline , HANSON, George , THOMPSON, David , CHASE, Lucas , SHIPLEY, Gary , WILSON, Elizabeth
IPC: C12N15/86
CPC classification number: C12N15/86 , C12N2710/16221 , C12N2710/16222 , C12N2710/16243 , C12N2799/022 , C12N2799/026 , C12N2799/027 , C12N2800/108 , C12N2820/002 , C12N2820/007 , C12N2820/60
Abstract: The disclosure relates generally to genetic manipulation of stem and primary cells and to reprogramming of somatic cells, more specifically, human cells. In particular, compositions and methods are disclosed for the generation and maintenance of such engineered cells.
Abstract translation: 本公开一般涉及干细胞和原代细胞的遗传操作和体细胞，更具体地，人类细胞的重新编程。 特别地，公开了用于产生和维护这种工程化细胞的组合物和方法。
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5.发明授权TAL-EFFECTOR ASSEMBLY PLATFORM, CUSTOMIZED SERVICES, KITS AND ASSAYS 有权TAL-EFFECTOR组装平台，定制服务，套件和测试
公开(公告)号：EP2834357B1
公开(公告)日：2017-12-27
申请号：EP13717658.2
申请日：2013-04-04
Inventor： KATZEN, Federico , CHESNUT, Jonathan , NOTKA, Frank , ARNOLD, Matthias , HOFF, Kevin , WHITESIDE, Stephen
CPC classification number: C12N15/1082 , C07K14/195 , C12N9/90 , C12N9/96 , C12N15/102 , C12N15/1086 , C12N15/1093 , C12N15/66 , C12Y599/01002
Abstract: The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.
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公开(公告)号：EP4401757A1
公开(公告)日：2024-07-24
申请号：EP22800037.8
申请日：2022-09-13
Applicant: Life Technologies Corporation
Inventor： CHESNUT, Jonathan , IHLAN, Alicia , POTTER, Robert , SONG, Youngzee
CPC classification number: C12N9/22 , C12N15/907 , C07K2319/8020130101 , A61K38/00 , C07K2319/8120130101
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7.发明公开
公开(公告)号：EP2834357A2
公开(公告)日：2015-02-11
申请号：EP13717658.2
申请日：2013-04-04
Applicant: Life Technologies Corporation , Geneart AG
Inventor： KATZEN, Federico , CHESNUT, Jonathan , NOTKA, Frank , ARNOLD, Matthias , HOFF, Kevin , WHITESIDE, Stephen
CPC classification number: C12N15/1082 , C07K14/195 , C12N9/90 , C12N9/96 , C12N15/102 , C12N15/1086 , C12N15/1093 , C12N15/66 , C12Y599/01002
Abstract: The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.
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公开(公告)号：EP2362912A1
公开(公告)日：2011-09-07
申请号：EP09850164.6
申请日：2009-11-13
Applicant: Life Technologies Corporation
Inventor： LAKSHMIPATHY, Uma , THYAGARAJAN, Bhaskar , CHESNUT, Jonathan , ANEST, Vasiliki , BENNETT, Robert , LIEU, Pauline , HANSON, George , THOMPSON, David , CHASE, Lucas , SHIPLEY, Gary , WILSON, Elizabeth
IPC: C12N15/86
CPC classification number: C12N15/86 , C12N2710/16221 , C12N2710/16222 , C12N2710/16243 , C12N2799/022 , C12N2799/026 , C12N2799/027 , C12N2800/108 , C12N2820/002 , C12N2820/007 , C12N2820/60
Abstract: The disclosure relates generally to genetic manipulation of stem and primary cells and to reprogramming of somatic cells, more specifically, human cells. In particular, compositions and methods are disclosed for the generation and maintenance of such engineered cells.
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